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Study · Animal study (in vivo) · mouse · 2023

17 results

Dulaglutide provides protection against sepsis-induced lung injury in mice by inhibiting inflammation and apoptosis.

Wang Y, Deng F, Zhong X, Du Y, Fan X, Su H, Pan T

European journal of pharmacology14 Apr 2023Cited by 23 (Europe PMC)

PMID37062504 (opens in a new tab)DOI10.1016/j.ejphar.2023.175730 (opens in a new tab)PepBankPUB-37062504
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study17

17 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, dulaglutide improved weight loss.

    In plain wordsIn mice, dulaglutide reduced weight loss compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseWeight loss
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In mice with LPS (15 mg/kg, ip, qd)-induced acute lung injury, the administration of dulaglutide (0.6 mg/kg, ip, qd) improved weight loss,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with LPS-induced lung injury, dulaglutide reduced lung injury.

    In plain wordsIn mice, dulaglutide reduced lung damage compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseLung injury
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In mice with LPS (15 mg/kg, ip, qd)-induced acute lung injury, the administration of dulaglutide (0.6 mg/kg, ip, qd) improved weight loss, reduced lung injury,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed increased lung IL-1β expression.

    In plain wordsIn mice, dulaglutide reduced lung IL-1β expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseIL-1β expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    reversed the increase in IL-1β, TNF-α, IL-6, CXCL1, CCL2 and CXCL2 expression in the lung,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed increased lung TNF-α expression.

    In plain wordsIn mice, dulaglutide reduced lung TNF-α expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseTNF-α expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    reversed the increase in IL-1β, TNF-α, IL-6, CXCL1, CCL2 and CXCL2 expression in the lung,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed increased lung IL-6 expression.

    In plain wordsIn mice, dulaglutide reduced lung IL-6 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseIL-6 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    reversed the increase in IL-1β, TNF-α, IL-6, CXCL1, CCL2 and CXCL2 expression in the lung,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed increased lung CXCL1 expression.

    In plain wordsIn mice, dulaglutide reduced lung CXCL1 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCXCL1 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    reversed the increase in IL-1β, TNF-α, IL-6, CXCL1, CCL2 and CXCL2 expression in the lung,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed increased lung CCL2 expression.

    In plain wordsIn mice, dulaglutide reduced lung CCL2 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCCL2 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    reversed the increase in IL-1β, TNF-α, IL-6, CXCL1, CCL2 and CXCL2 expression in the lung,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed increased lung CXCL2 expression.

    In plain wordsIn mice, dulaglutide reduced lung CXCL2 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCXCL2 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    reversed the increase in IL-1β, TNF-α, IL-6, CXCL1, CCL2 and CXCL2 expression in the lung,
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reduced lung neutrophil infiltration.

    In plain wordsIn mice, dulaglutide reduced lung neutrophil infiltration compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseNeutrophil infiltration
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    and reduced the infiltration of neutrophils and macrophages in the lung tissues.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reduced lung macrophage infiltration.

    In plain wordsIn mice, dulaglutide reduced lung macrophage infiltration compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseMacrophage infiltration
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    and reduced the infiltration of neutrophils and macrophages in the lung tissues.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed the decline in lung caspase-3 expression.

    In plain wordsIn mice, dulaglutide reversed lower lung caspase-3 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseCaspase-3 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The decline in caspase-3, cleaved caspase-3, caspase-8, and Bcl-2/Bax expression and the increase in the number of TUNEL positive cells in the lung were reversed, suggesting that GLP-1RA could play a protective role in the lung by inhibiting inflammation and apoptosis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed the decline in cleaved caspase-3 expression.

    In plain wordsIn mice, dulaglutide reversed lower cleaved caspase-3 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseCleaved caspase-3 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The decline in caspase-3, cleaved caspase-3, caspase-8, and Bcl-2/Bax expression and the increase in the number of TUNEL positive cells in the lung were reversed, suggesting that GLP-1RA could play a protective role in the lung by inhibiting inflammation and apoptosis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed the decline in caspase-8 expression.

    In plain wordsIn mice, dulaglutide reversed lower caspase-8 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseCaspase-8 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The decline in caspase-3, cleaved caspase-3, caspase-8, and Bcl-2/Bax expression and the increase in the number of TUNEL positive cells in the lung were reversed, suggesting that GLP-1RA could play a protective role in the lung by inhibiting inflammation and apoptosis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed the decline in Bcl-2/Bax expression.

    In plain wordsIn mice, dulaglutide reversed lower Bcl-2/Bax expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseBcl-2/Bax expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The decline in caspase-3, cleaved caspase-3, caspase-8, and Bcl-2/Bax expression and the increase in the number of TUNEL positive cells in the lung were reversed, suggesting that GLP-1RA could play a protective role in the lung by inhibiting inflammation and apoptosis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  15. 15AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reversed the increase in lung TUNEL-positive cells.

    In plain wordsIn mice, dulaglutide reduced lung TUNEL-positive cells compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseTUNEL-positive cells
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Cell viability and death · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The decline in caspase-3, cleaved caspase-3, caspase-8, and Bcl-2/Bax expression and the increase in the number of TUNEL positive cells in the lung were reversed, suggesting that GLP-1RA could play a protective role in the lung by inhibiting inflammation and apoptosis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  16. 16AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reduced P-STAT3 expression.

    In plain wordsIn mice, dulaglutide reduced P-STAT3 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseP-STAT3 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, GLP-1RA could reduce the expression of P-STAT3 and NLRP3, suggesting that P-STAT3 and NLRP3 may be potential targets against lung injury in sepsis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.
  17. 17AnimalAnimal study (in vivo)Mechanism

    In mice with septic lung injury, dulaglutide reduced NLRP3 expression.

    In plain wordsIn mice, dulaglutide reduced NLRP3 expression compared with LPS injury alone.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseNLRP3 expression
    Study

    mousen: not reported in source

    LPS-induced septic lung injury
    Comparator
    LPS-induced injury
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    0.6 mg/kg daily · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    In addition, GLP-1RA could reduce the expression of P-STAT3 and NLRP3, suggesting that P-STAT3 and NLRP3 may be potential targets against lung injury in sepsis.
    1 context sentence
    Summary · context
    In this study, we investigated the effects and mechanism of action of dulaglutide (Dul) in lipopolysaccharide (LPS) induced lung injury in mice with sepsis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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