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Study · Animal study (in vivo) · mouse · 2023

21 results

Dulaglutide Ameliorates Intrauterine Adhesion by Suppressing Inflammation and Epithelial-Mesenchymal Transition via Inhibiting the TGF-β/Smad2 Signaling Pathway.

Wang Y, Wang Y, Wu Y, Wang Y

Pharmaceuticals (Basel, Switzerland)5 Jul 2023Cited by 24 (Europe PMC)

PMID37513876 (opens in a new tab)PMCIDPMC10384231 (opens in a new tab)DOI10.3390/ph16070964 (opens in a new tab)PepBankPUB-37513876
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Jump to 21 results

Summary

Intrauterine adhesion (IUA) is a common gynecological disease with limited therapeutic options. Dulaglutide is a long-acting glucagon-like peptide-1 (GLP-1) analog with some anti-fibrotic and anti-inflammatory properties; however, its action on IUA remains uncertain. The purpose of the experiments in this study was to explore the effect of dulaglutide on IUA and to elucidate its mechanism to provide new ideas for the clinical treatment of IUA. An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control), and sham-operated mice were treated similarly to the control mice. Mice were sacrificed, and uterine tissues were subjected to hematoxylin and eosin (H&E) and Masson's trichrome staining for histomorphological and pathological analyses and real-time quantitative polymerase chain reaction (RT-qPCR) and Western blotting (WB) for gene and protein expression analyses. Dulaglutide improved the shape of the uterine cavity, increased endometrial thickness and the number of glands, and significantly reduced the area of collagen fiber deposition in the endometrium. It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels and COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels. This study demonstrates that dulaglutide reduces inflammatory responses by inhibiting M1 macrophage polarization and inflammatory factor release and may ameliorate fibrosis by inhibiting epithelial-mesenchymal transition (EMT) via TGF-β/Smad2 signaling.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study21

21 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intrauterine adhesion, dulaglutide improved uterine cavity shape compared with control.

    In plain wordsIn mice with uterine adhesions, dulaglutide improved uterine cavity shape compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    Not applicableUterine cavity shape
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    Dulaglutide improved the shape of the uterine cavity, increased endometrial thickness and the number of glands, and significantly reduced the area of collagen fiber deposition in the endometrium.
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intrauterine adhesion, dulaglutide increased endometrial thickness compared with control.

    In plain wordsIn mice with uterine adhesions, dulaglutide increased uterine lining thickness compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseEndometrial thickness
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    Dulaglutide improved the shape of the uterine cavity, increased endometrial thickness and the number of glands, and significantly reduced the area of collagen fiber deposition in the endometrium.
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intrauterine adhesion, dulaglutide increased gland number compared with control.

    In plain wordsIn mice with uterine adhesions, dulaglutide increased gland numbers compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseEndometrial glands
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Vaginal and urogenital health · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    Dulaglutide improved the shape of the uterine cavity, increased endometrial thickness and the number of glands, and significantly reduced the area of collagen fiber deposition in the endometrium.
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with intrauterine adhesion, dulaglutide reduced endometrial collagen deposition compared with control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced collagen deposits compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCollagen deposition
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    Dulaglutide improved the shape of the uterine cavity, increased endometrial thickness and the number of glands, and significantly reduced the area of collagen fiber deposition in the endometrium.
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced COL1A1 mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced COL1A1 gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCOL1A1 mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced IL-1β mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced IL-1β gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseIL-1β mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced IL-6 mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced IL-6 gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseIL-6 mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  8. 08AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced TNF-α mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced TNF-α gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseTNF-α mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  9. 09AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced CCL2 mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced CCL2 gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCCL2 mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced F4/80 mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced F4/80 gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseF4/80 mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Immune response · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced vimentin mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced vimentin gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseVimentin mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  12. 12AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced TGF-β mRNA versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced TGF-β gene activity compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseTGF-β mRNA
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    1 context sentence
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  13. 13AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced COL1A1 protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced COL1A1 protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseCOL1A1 protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  14. 14AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced IL-1β protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced IL-1β protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseIL-1β protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  15. 15AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced IL-6 protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced IL-6 protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseIL-6 protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  16. 16AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced TNF-α protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced TNF-α protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseTNF-α protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  17. 17AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced F4/80 protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced F4/80 protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseF4/80 protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Immune response · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  18. 18AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced vimentin protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced vimentin protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseVimentin protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  19. 19AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced E-cadherin protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced E-cadherin protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseE-cadherin protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Organ injury · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  20. 20AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced TGF-β protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced TGF-β protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseTGF-β protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)
  21. 21AnimalAnimal study (in vivo)Mechanism

    In mice with intrauterine adhesion, dulaglutide reduced p-Smad2 protein versus control.

    In plain wordsIn mice with uterine adhesions, dulaglutide reduced p-Smad2 protein compared with control.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    Decreasep-Smad2 protein
    Study

    mousen: not reported in source

    Intrauterine adhesion induced by curettage and inflammation
    Comparator
    Sterile ddH2O control
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated · subcutaneous injection · two weeksAs given in this study (mouse).

    Source sentences

    Summary
    COL1A1, IL-1β, IL-6, TNF-α, F4/80, vimentin, E-cadherin, TGF-β, and p-Smad2 protein expression levels.
    2 context sentences
    Summary · context
    It significantly reduced collagen type I A 1 (COL1A1), interleukin-1beta (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), C-C motif chemokine ligand 2 (CCL2), F4/80 (macrophage), vimentin and transforming growth factor-beta (TGF-β) mRNA levels
    Summary · context
    An IUA mouse model was established via mechanical curettage and inflammation induction; mice received subcutaneous injection with three doses of dulaglutide once a day for two weeks (treatment) or equal amounts of sterile ddH2O (control)

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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