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Study · Animal study (in vivo) · mouse · 2025

20 results

Dulaglutide accelerates diabetic wound healing by suppressing Nrf2-dependent ferroptosis in diabetic mice.

Xi L, Du J, Lu Y, Xue W, Xia Y, Chen T, Xiao Y, Xu N, Wang Y, Gao J, Li W, Huang S

Peptides13 Feb 2025Cited by 11 (Europe PMC)

PMID39954860 (opens in a new tab)DOI10.1016/j.peptides.2025.171366 (opens in a new tab)PepBankPUB-39954860
Publisher pagePubMedAsk about this study
Jump to 20 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study20

20 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide increased VEGF expression during wound healing.

    In plain wordsIn mice with diabetes, dulaglutide increased VEGF expression during wound healing.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseVEGF expression
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness wounds
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that dulaglutide treatment increased the expression of vascular endothelial growth factor (VEGF) and the proliferation marker Ki67, thereby accelerating wound healing in diabetic mice.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide increased Ki67 expression during wound healing.

    In plain wordsIn mice with diabetes, dulaglutide increased Ki67 expression during wound healing.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseKi67 expression
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness wounds
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that dulaglutide treatment increased the expression of vascular endothelial growth factor (VEGF) and the proliferation marker Ki67, thereby accelerating wound healing in diabetic mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In diabetic mice, dulaglutide accelerated wound healing.

    In plain wordsIn mice with diabetes, dulaglutide accelerated wound healing.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseWound healing
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness wounds
    Outcome group
    Wound healing · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    The results demonstrated that dulaglutide treatment increased the expression of vascular endothelial growth factor (VEGF) and the proliferation marker Ki67, thereby accelerating wound healing in diabetic mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide reversed the increase in iron levels reported in the high-glucose experiments.

    In plain wordsIn mice with diabetes, dulaglutide reversed the increase in iron levels.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseFe2+ levels
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    2 context sentences
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
    Summary · context
    Round-shape, full-thickness wounds were created on the backs of db/db diabetic mice. Subsequently, dulaglutide was delivered via subcutaneous injections surrounding the wound's perimeter, and the wound closure rates were monitored.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide reversed the increase in reactive oxygen species.

    In plain wordsIn mice with diabetes, dulaglutide reversed the increase in reactive oxygen species.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseROS levels
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    2 context sentences
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
    Summary · context
    Round-shape, full-thickness wounds were created on the backs of db/db diabetic mice. Subsequently, dulaglutide was delivered via subcutaneous injections surrounding the wound's perimeter, and the wound closure rates were monitored.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide reversed the increase in malondialdehyde.

    In plain wordsIn mice with diabetes, dulaglutide reversed the increase in malondialdehyde.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseMDA levels
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    2 context sentences
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
    Summary · context
    Round-shape, full-thickness wounds were created on the backs of db/db diabetic mice. Subsequently, dulaglutide was delivered via subcutaneous injections surrounding the wound's perimeter, and the wound closure rates were monitored.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide reversed the decrease in glutathione.

    In plain wordsIn mice with diabetes, dulaglutide reversed the decrease in glutathione.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseGSH levels
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    2 context sentences
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
    Summary · context
    Round-shape, full-thickness wounds were created on the backs of db/db diabetic mice. Subsequently, dulaglutide was delivered via subcutaneous injections surrounding the wound's perimeter, and the wound closure rates were monitored.
  8. 08AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide reversed the decrease in superoxide dismutase.

    In plain wordsIn mice with diabetes, dulaglutide reversed the decrease in superoxide dismutase.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseSOD levels
    Study

    mousen: not reported in source

    db/db diabetic mice
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    2 context sentences
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
    Summary · context
    Round-shape, full-thickness wounds were created on the backs of db/db diabetic mice. Subsequently, dulaglutide was delivered via subcutaneous injections surrounding the wound's perimeter, and the wound closure rates were monitored.
  9. 09AnimalAnimal study (in vivo)Mechanism

    In diabetic mice, dulaglutide reversed the ferroptosis reported in the high-glucose experiments.

    In plain wordsIn mice with diabetes, dulaglutide reversed ferroptosis in the high-glucose experiments.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseFerroptosis
    Study

    mousen: not reported in source

    db/db diabetic mice with full-thickness wounds
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated · subcutaneous injections surrounding the woundAs given in this study (mouse).

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    2 context sentences
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
    Summary · context
    Round-shape, full-thickness wounds were created on the backs of db/db diabetic mice. Subsequently, dulaglutide was delivered via subcutaneous injections surrounding the wound's perimeter, and the wound closure rates were monitored.
  10. 10LabIn vitro (cells)Activity measurement

    In HaCaT cells under high glucose, dulaglutide promoted proliferation.

    In plain wordsIn cells under high glucose, dulaglutide promoted proliferation.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseCell proliferation
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, dulaglutide promoted HaCaT cell proliferation and migration under HG conditions.
  11. 11LabIn vitro (cells)Activity measurement

    In HaCaT cells under high glucose, dulaglutide promoted migration.

    In plain wordsIn cells under high glucose, dulaglutide promoted migration.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseCell migration
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vitro, dulaglutide promoted HaCaT cell proliferation and migration under HG conditions.
  12. 12LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide reversed the increase in iron levels.

    In plain wordsIn cells under high glucose, dulaglutide reversed the increase in iron levels.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseFe2+ levels
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    1 context sentence
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
  13. 13LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide reversed the increase in reactive oxygen species.

    In plain wordsIn cells under high glucose, dulaglutide reversed the increase in reactive oxygen species.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseROS levels
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    1 context sentence
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
  14. 14LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide reversed the increase in malondialdehyde.

    In plain wordsIn cells under high glucose, dulaglutide reversed the increase in malondialdehyde.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseMDA levels
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    1 context sentence
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
  15. 15LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide reversed the decrease in glutathione.

    In plain wordsIn cells under high glucose, dulaglutide reversed the decrease in glutathione.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseGSH levels
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    1 context sentence
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
  16. 16LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide reversed the decrease in superoxide dismutase.

    In plain wordsIn cells under high glucose, dulaglutide reversed the decrease in superoxide dismutase.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseSOD levels
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    All these effects were reversed by dulaglutide.
    1 context sentence
    Summary · context
    Exposure of HaCaT cells to HG resulted in ferroptosis in vivo and in vitro, as evidenced by the significant increase in Fe2+, reactive oxygen species (ROS), and malondialdehyde (MDA) levels and the decrease in glutathione (GSH) and superoxide dismutase (SOD) levels.
  17. 17LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide activated Nrf2 signaling.

    In plain wordsIn cells under high glucose, dulaglutide activated Nrf2 signaling.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseNrf2 signaling
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, dulaglutide activated NFE2-related factor 2 (Nrf2) signaling under HG conditions, which increased glutathione peroxidase (Gpx4) and solute carrier family 7-member 11 (Slc7a11) expression, thereby inhibiting ferroptosis.
  18. 18LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide increased Gpx4 expression through Nrf2 signaling.

    In plain wordsIn cells under high glucose, dulaglutide increased Gpx4 expression through Nrf2 signaling.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseGpx4 expression
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, dulaglutide activated NFE2-related factor 2 (Nrf2) signaling under HG conditions, which increased glutathione peroxidase (Gpx4) and solute carrier family 7-member 11 (Slc7a11) expression, thereby inhibiting ferroptosis.
  19. 19LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide increased Slc7a11 expression through Nrf2 signaling.

    In plain wordsIn cells under high glucose, dulaglutide increased Slc7a11 expression through Nrf2 signaling.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    IncreaseSlc7a11 expression
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, dulaglutide activated NFE2-related factor 2 (Nrf2) signaling under HG conditions, which increased glutathione peroxidase (Gpx4) and solute carrier family 7-member 11 (Slc7a11) expression, thereby inhibiting ferroptosis.
  20. 20LabIn vitro (cells)Mechanism

    In high-glucose experiments, dulaglutide inhibited ferroptosis through Nrf2 signaling.

    In plain wordsIn cells under high glucose, dulaglutide inhibited ferroptosis through Nrf2 signaling.

    Peptide
    Dulaglutide (Trulicity)
    Outcome
    DecreaseFerroptosis
    Study

    n: not reported in source

    HaCaT cells under high glucose
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Mechanistically, dulaglutide activated NFE2-related factor 2 (Nrf2) signaling under HG conditions, which increased glutathione peroxidase (Gpx4) and solute carrier family 7-member 11 (Slc7a11) expression, thereby inhibiting ferroptosis.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 18:59 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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