Colivelin / Studies

Synthetic analog · 26 amino acids · 2,645.1 Da

Colivelin studies and research data

PepBank has 23 colivelin studies with results. None of them gave colivelin. Data as of 2026-10-30.

Searches 0 results and 193 papers. Newer studies from Europe PMC

Results in people

0% of 0 results

Results in animals

0% of 0 results

Results in lab cells

0% of 0 results

From computer models

0% of 0 results

The molecule

Colivelin identity

Identifiers, parent molecule, targets and development stage, from curated data.

Colivelin joins ADNF-9 to a modified humanin-derived sequence. Its sequence is SALLRSIPAPAGASRLLLLTGEIDLP. Preclinical studies examine neuroprotection and STAT3-associated signaling. Native humanin and colivelin are distinct.

Kind: Synthetic analog · 26 residues
Identifiers: PubChem CID90477169 (opens in a new tab)CAS867021-83-8
Parent: Analog of HumaninA modified humanin-derived sequence joins ADNF-9. It is not one contiguous native humanin fragment.
Development: PreclinicalThe original study and subsequent animal and laboratory studies establish preclinical research. ClinicalTrials.gov searches for the intervention and exact name returned zero records. Vendor-listed CLN disease and unrelated drug trials do not establish human testing of colivelin. No current commercial developer was established. Source (opens in a new tab)

Targets

No molecular target is recorded for this peptide.

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

26 amino acids

H-

SALLRSIPAP

AGASRLLLLT

GEIDLP

Alignment to Humanin

Calculated from the two sequences. Curated notes are shown as given.

14 of 19 aligned residues identical (74%) · 5 substitutions · 7 added residues · Humanin 1–19

Top row: Humanin (parent)
Bottom row: Colivelin

GSLLLLT

EIDLP

Same as parent
Substituted
Non-canonical or D-form
Added
Gap
Modified side chain or end
Parent context

Differences from the parent

1Not in parent · analog 1+ Ser · Added residue
2Not in parent · analog 2+ Ala · Added residue
3Not in parent · analog 3+ Leu · Added residue
4Not in parent · analog 4+ Leu · Added residue
5Not in parent · analog 5+ Arg · Added residue
6Not in parent · analog 6+ Ser · Added residue
7Not in parent · analog 7+ Ile · Added residue
8Parent 1 · analog 8Met → Pro · Substitution
9Parent 4 · analog 11Arg → Ala · Substitution
10Parent 6 · analog 13Phe → Ala · Substitution
11Parent 8 · analog 15Cys → Arg · Substitution
12Parent 14 · analog 21Ser → Gly · Substitution

Basis: A modified humanin-derived sequence joins ADNF-9. It is not one contiguous native humanin fragment.

Calculated from the two sequences with @pepdb/chem alignToParent (ungapped unless a gap scores higher). The record’s curated notes are shown as given.

Properties

From identity sources

Formula: C₁₁₉H₂₀₆N₃₂O₃₅
Molecular weight: 2,645.1 g/mol
Monoisotopic mass: 2,643.5323 Da

PubChem CID 90477169(opens in a new tab)retrieved 2026-10-27
pmc oa PMC6725789(opens in a new tab)retrieved 2026-10-27

Calculated from the sequence

pKa set

Average mass: 2,645.14 Da; Sum of ExPASy residue masses + water · ExPASy Compute pI/Mw; FindMod
Monoisotopic mass: 2,643.5323 Da; Sum of ExPASy residue masses + water · ExPASy FindMod
Isoelectric point (pI): 6.50; pH of zero net charge, EMBOSS pKa set · EMBOSS iep, Epk.dat
Net charge at pH 7.4: −0.06; Henderson-Hasselbalch, EMBOSS pKa set · EMBOSS iep, Epk.dat
GRAVY (hydropathy): 0.696; Mean Kyte-Doolittle hydropathy · Kyte and Doolittle 1982; Positive: hydrophobic on average.
Extinction coefficient, 280 nm (Cys reduced): 0 M⁻¹ cm⁻¹; 5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam); No Trp or Tyr: absorbance at 280 nm cannot measure this peptide.
Instability index: 67.83; Dipeptide instability weights (DIWV) · Guruprasad et al. 1990; Above 40: classed as possibly unstable (ExPASy).
Aliphatic index: 150.4; Mole % A + 2.9 V + 3.9 (I + L) · Ikai 1980
Boman index: 0.18 kcal/mol; Mean solubility value (negated) · Boman 2003; 2.48 or below: lower protein-binding potential (Boman).
Hydrophobic moment (μH): 0.431; Eisenberg scale, 100° per residue, best 11-residue window · Eisenberg et al. 1982, 1984
pI with each pKa set: EMBOSS 6.50Bjellqvist (ExPASy) 5.79IPC peptide 7.01IPC protein 6.81

Defined and validated for proteins; use with care for short peptides.
Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

pI 6.50 · Net charge at pH 7.4: −0.06

Point or use arrow keys

Henderson-Hasselbalch, EMBOSS pKa set. Calculated, not measured.

Show as table

pH	Net charge
0	3.00
1	3.00
2	2.96
3	2.61
4	1.28
5	0.22
6	0.02
7	−0.02
8	−0.20
9	−0.72
10	−0.97
11	−1.06
12	−1.48
13	−2.52
14	−2.94

Composition

Hydrophobic50% (13)A I L
Positive8% (2)R
Negative8% (2)D E
Polar15% (4)S T
Special19% (5)G P

26 residues. Each residue counts in one class; F and W count as aromatic.

A Ala4 · 15%

I Ile2 · 8%

L Leu7 · 27%

M Met0 · 0%

V Val0 · 0%

F Phe0 · 0%

W Trp0 · 0%

Y Tyr0 · 0%

H His0 · 0%

K Lys0 · 0%

R Arg2 · 8%

D Asp1 · 4%

E Glu1 · 4%

N Asn0 · 0%

Q Gln0 · 0%

S Ser3 · 12%

T Thr1 · 4%

C Cys0 · 0%

G Gly2 · 8%

P Pro3 · 12%

3D structure

No 3D structure

No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.

2D structure

Colivelin has 26 residues. A full-atom drawing is hard to read at this size; the sequence view is the reference.

SMILES fromPubChem CID 90477169(opens in a new tab)

CC[C@H](C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]2CCCN2C(=O)[C@H](C)NC(=O)[C@@H]3CCCN3C(=O)[C@H]([C@@H](C)CC)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)N

Helical wheel

An ideal alpha-helix projection. It shows where the hydrophobic residues fall if the peptide folds as a helix. It does not show that it does.

μH, residues shown: 0.152
μH, best 11-residue window: 0.431
Arrow direction: 198°
Residues: 26 · 2 rings of 18

HydrophilicHydrophobic

Eisenberg consensus (normalized) scale · + K, R · − D, E

Assumes an ideal α-helix: 100° per residue, 3.6 residues per turn. The arrow is the mean hydrophobic moment (Eisenberg et al. 1984) and points at the hydrophobic face.

Show as table

Position	Residue	Angle	Eisenberg consensus (normalized)
1	S	0°	-0.18
2	A	100°	0.62
3	L	200°	1.06
4	L	300°	1.06
5	R	40°	-2.53
6	S	140°	-0.18
7	I	240°	1.38
8	P	340°	0.12
9	A	80°	0.62
10	P	180°	0.12
11	A	280°	0.62
12	G	20°	0.48
13	A	120°	0.62
14	S	220°	-0.18
15	R	320°	-2.53
16	L	60°	1.06
17	L	160°	1.06
18	L	260°	1.06
19	L	0°	1.06
20	T	100°	-0.05
21	G	200°	0.48
22	E	300°	-0.74
23	I	40°	1.38
24	D	140°	-0.90
25	L	240°	1.06
26	P	340°	0.12

Results by area

Colivelin results by year and outcome

Counts are exact and come from studies that gave the peptide.

Studies by year

23 of 193 studies have results (12%), published 2005 to 2026. Top row: every study. Bottom row: studies with results about Colivelin, by class. The rows use different scales.

Studies
Human
Animal
Lab
Computer model
Natural levels, tool or combination only

Studies193 in all, 2005 to 2027

Studies with results23 in all, 2005 to 2026

Retracted studies are left out. A study with results in two classes counts in both.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

No study of Colivelin has results in PepBank yet.

Trials and papers

Colivelin trials

Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.

StatusPhase

0 trials match. Highest phase first. Data from ClinicalTrials.gov.

No trial matches these filters.

Papers

Studies on this peptide. Some have results. The others have none yet.

Sort

Design

193 studies match. Retracted studies are left out.

Showing 25 of 193 studiesquery qry_e88fb72ad0d88f06cd0cc7f1

Studies with results

23 studies in all, 8 on this page

Not a test of Colivelin alone · 2009

3 results

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

Chiba et al. 2009Molecular psychiatrycited by 179

PMID 18813209DOI 10.1038/mp.2008.105PUB-18813209

Rights unknown2 results where Colivelin was a tool, carrier or part of a combination

Source link See results (3)

Not a test of Colivelin alone · 2005

14 results

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.

Chiba et al. 2005The Journal of neuroscience : the official journal of the Society for Neurosciencecited by 71

PMID 16267233PMC6725789DOI 10.1523/jneurosci.3348-05.2005PUB-16267233

Free to read · publisher termsCC BY-NC8 results where Colivelin was a tool, carrier or part of a combination

Read at source See results (14)

Not a test of Colivelin alone · 2008

7 results

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease.

Yamada et al. 2008Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacologycited by 46

PMID 17928813DOI 10.1038/sj.npp.1301591PUB-17928813

Rights unknown3 results where Colivelin was a tool, carrier or part of a combination

Source link See results (7)

Not a test of Colivelin alone · 2008

4 results

The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues.

Kunesová et al. 2008Peptidescited by 33

PMID 18647630DOI 10.1016/j.peptides.2008.06.019PUB-18647630

Full text at the publisher1 result where Colivelin was a tool, carrier or part of a combination

Publisher page See results (4)

Not a test of Colivelin alone · 2019

14 results

Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.

Zhao et al. 2019Neurosciencecited by 33

PMID 31374230DOI 10.1016/j.neuroscience.2019.07.020PUB-31374230

Full text at the publisher7 results where Colivelin was a tool, carrier or part of a combination

Publisher page See results (14)

Not a test of Colivelin alone · 2022

21 results

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

Urban et al. 2022Frontiers in immunologycited by 33

PMID 36119052PMC9478210DOI 10.3389/fimmu.2022.984298PUB-36119052

CC BY10 results where Colivelin was a tool, carrier or part of a combination

Download PDF See results (21)

Not a test of Colivelin alone · 2006

7 results

Colivelin prolongs survival of an ALS model mouse.

Chiba et al. 2006Biochemical and biophysical research communicationscited by 30

PMID 16564029DOI 10.1016/j.bbrc.2006.02.184PUB-16564029

Full text at the publisher4 results where Colivelin was a tool, carrier or part of a combination

Publisher page See results (7)

Not a test of Colivelin alone · 2023

3 results

Exercise maintains bone homeostasis by promoting osteogenesis through STAT3.

Huang et al. 2023International journal of biological sciencescited by 24

PMID 37151888PMC10158023DOI 10.7150/ijbs.82744PUB-37151888

CC BY3 results where Colivelin was a tool, carrier or part of a combination

Download PDF See results (3)

More studies

162 studies in all, 17 on this page

PubMed tag: Review · 2009

Targeting the JAK2/STAT3 axis in Alzheimer's disease.

Chiba et al. 2009Expert opinion on therapeutic targetscited by 116

PMID 19663649DOI 10.1517/14728220903213426PUB-19663649

Full text at the publisher

Publisher page

Indexing hint: Animal study · 2023

The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation.

Zhong et al. 2023Theranosticscited by 74

PMID 37441601PMC10334828DOI 10.7150/thno.82535PUB-37441601

CC BY

Download PDF

PubMed tag: none · 2020

Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene.

Li et al. 2020Journal of cellular and molecular medicinecited by 47

Guo et al. 2021Agingcited by 25

PMID 34320467PMC8351699DOI 10.18632/aging.203301PUB-34320467

CC BY

Download PDF

Newer studies

PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.

Colivelin studies: 23 papers with results

Page 1 of 1

The role of STAT3-targeted therapy created with COLIVELIN in the cross-talk between IL6/JAK2/STAT3 and TGF-β/SMAD2/SMAD3 signaling in a hyperinflammation and ROS-induced in vitro AMD model and its effect on retinal apoptosis.
Güçlü H · International ophthalmology · 2026
Not a test of Colivelin alone · 14 results
Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.
Urban C · Frontiers in immunology · 2022
Not a test of Colivelin alone · 21 results
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.
Chiba T · The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005
Not a test of Colivelin alone · 14 results
A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations.
Sari Y · Neuroscience · 2009
Not a test of Colivelin alone · 8 results
Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.
Zhao H · Neuroscience · 2019
Not a test of Colivelin alone · 14 results
Saikosaponin A alleviates glycolysis of breast cancer cells through repression of Akt/STAT3 pathway.
Zhang Y · Chemical biology & drug design · 2023
Not a test of Colivelin alone · 7 results
PM2.5 promoted lipid accumulation in macrophage via inhibiting JAK2/STAT3 signaling pathways and aggravating the inflammatory reaction.
Yang L · Ecotoxicology and environmental safety · 2021
Not a test of Colivelin alone · 5 results
Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice.
Wu M · Journal of Alzheimer's disease : JAD · 2017
Not a test of Colivelin alone · 10 results
Colivelin prolongs survival of an ALS model mouse.
Chiba T · Biochemical and biophysical research communications · 2006
Not a test of Colivelin alone · 7 results
Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats.
Wu MN · Hippocampus · 2015
Not a test of Colivelin alone · 7 results
SOCS1, the feedback regulator of STAT1/3, inhibits the osteogenic differentiation of rat bone marrow mesenchymal stem cells.
Zhang Y · Gene · 2022
Not a test of Colivelin alone · 4 results
Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease.
Yamada M · Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2008
Not a test of Colivelin alone · 7 results
Exercise maintains bone homeostasis by promoting osteogenesis through STAT3.
Huang X · International journal of biological sciences · 2023
Not a test of Colivelin alone · 3 results
Dendrobine regulates STAT3 to attenuate mitochondrial dysfunction and senescence in vascular endothelial cells triggered by oxidized low-density lipoprotein.
Xia J · Drug development research · 2024
Not a test of Colivelin alone · 3 results
Ghrelin ameliorates sepsis-induced acute skeletal muscle wasting via hypothalamic JAK2/STAT3-AgRP pathway.
Duan K · International journal of surgery (London, England) · 2025
Not a test of Colivelin alone · 3 results
High glucose promotes macrophage switching to the M1 phenotype via the downregulation of STAT-3 mediated autophagy.
Zhao Y · PloS one · 2024
Not a test of Colivelin alone · 3 results
Analysis of the improvement effect of Astragalus extract on oxidative stress injury in viral myocarditis through STAT3/IL-6.
Chang Z · Cellular and molecular biology (Noisy-le-Grand, France) · 2023
Not a test of Colivelin alone · 3 results
Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.
Chiba T · Molecular psychiatry · 2009
Not a test of Colivelin alone · 3 results
The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues.
Kunesová G · Peptides · 2008
Not a test of Colivelin alone · 4 results
GANT61 suppresses cell survival, invasion and epithelial-mesenchymal transition through inactivating AKT/mTOR and JAK/STAT3 pathways in anaplastic thyroid carcinoma.
Gao H · Cancer biology & therapy · 2022
Not a test of Colivelin alone · 1 result
Xuanfei Baidu Decoction suppresses complement overactivation and ameliorates IgG immune complex-induced acute lung injury by inhibiting JAK2/STAT3/SOCS3 and NF-κB signaling pathway.
Li C · Phytomedicine : international journal of phytotherapy and phytopharmacology · 2023
Not a test of Colivelin alone · 1 result
Supplementation with IL-6 and Muscle Cell Culture Conditioned Media Enhances Myogenic Differentiation of Adipose Tissue-Derived Stem Cells through STAT3 Activation.
Seo E · International journal of molecular sciences · 2018
Not a test of Colivelin alone · 1 result
Involvement of STAT3 activation in ameliorating all-trans-retinal-induced ferroptosis in photoreceptor-derived 661W cells in vitro.
Chen C · Experimental eye research · 2025
Not a test of Colivelin alone · 1 result

Status and safety

Regulatory and safety

Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.

Regulatory status by jurisdiction, with date and source
Jurisdiction	Body	Status	As of	Source
US	FDA	The exact active-ingredient search in openFDA Drugs@FDA returned no matches. This result does not prove absence from every FDA record.	27 Oct 2026	api.fda.gov (opens in a new tab)
EU	EMA	Current central and national medicinal approvals were not established from the sources for this profile.	27 Oct 2026	Not recorded
Sport	WADA	Status unknown The 2026 list does not name colivelin.	2026 List	wada-ama.org (opens in a new tab)

Safety outcomes

Reported effects from study results.

No study results yet

No safety results yet. That does not mean the peptide is safe.

Doses studied

The doses that these studies used. They are not recommendations.

No dose was reported in the study results.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Data

Data and API

Data version, change history and code for this peptide.

Data version 30856030 Oct 2026

Peptide

Peptide id: PEP-000123
Peptide version: 2
Peptide hash: e67b93b3e6e3463c…
Data version: 308560

Latest changes

27 Oct 2026UpdatedData version 287285
27 Oct 2026CreatedData version 256658

For developers

curl -s https://pepbank.io/v1/briefs/colivelin

Evidence summary for Colivelin: counts by class, key results with sources, notices, data version.

Peptide as JSON Evidence summary as JSON

Colivelin studies and research data

Colivelin identity

Targets

Sequence and structure

Sequence

Alignment to Humanin

Properties

Net charge by pH

Composition

3D structure

2D structure

Helical wheel

Colivelin results by year and outcome

What the studies measured

Colivelin trials

Papers

Studies with results

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease.

The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues.

Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

Colivelin prolongs survival of an ALS model mouse.

Exercise maintains bone homeostasis by promoting osteogenesis through STAT3.

More studies

Targeting the JAK2/STAT3 axis in Alzheimer's disease.

The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation.

Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene.

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.

Sea Hare Hydrolysate-Induced Reduction of Human Non-Small Cell Lung Cancer Cell Growth through Regulation of Macrophage Polarization and Non-Apoptotic Regulated Cell Death Pathways.

FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma.

Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway.

Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells.

Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells' Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway.

Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.

Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.

Banxia xiexin decoction affects drug sensitivity in gastric cancer cells by regulating MGMT expression via IL‑6/JAK/STAT3‑mediated PD‑L1 activity.

A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion.

Piperlongumine loaded PLGA nanoparticles inhibit cancer stem-like cells through modulation of STAT3 in mammosphere model of triple negative breast cancer.

Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling.

MFG-E8 alleviates oxygen-glucose deprivation-induced neuronal cell apoptosis by STAT3 regulating the selective polarization of microglia.

The anti-dysenteric drug fraxetin enhances anti-tumor efficacy of gemcitabine and suppresses pancreatic cancer development by antagonizing STAT3 activation.

Newer studies

Colivelin studies: 23 papers with results

Regulatory and safety

Doses studied

Data and API

Peptide

Latest changes

For developers

Related peptides

Colivelin results by year and outcome

Colivelin trials

Papers

Studies with results

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.

Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease.

The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues.

Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

Colivelin prolongs survival of an ALS model mouse.

Exercise maintains bone homeostasis by promoting osteogenesis through STAT3.

More studies

Targeting the JAK2/STAT3 axis in Alzheimer's disease.

The HDAC10 instructs macrophage M2 program via deacetylation of STAT3 and promotes allergic airway inflammation.

Farnesoid X receptor activation induces antitumour activity in colorectal cancer by suppressing JAK2/STAT3 signalling via transactivation of SOCS3 gene.

Humanin and colivelin: neuronal-death-suppressing peptides for Alzheimer's disease and amyotrophic lateral sclerosis.

Sea Hare Hydrolysate-Induced Reduction of Human Non-Small Cell Lung Cancer Cell Growth through Regulation of Macrophage Polarization and Non-Apoptotic Regulated Cell Death Pathways.

FANCD2 inhibits ferroptosis by regulating the JAK2/STAT3 pathway in osteosarcoma.

Jiawei Yanghe Decoction suppresses breast cancer by regulating immune responses via JAK2/STAT3 signaling pathway.

Polydatin induces apoptosis and autophagy via STAT3 signaling in human osteosarcoma MG-63 cells.

Curcumin Analogue L48H37 Suppresses Human Osteosarcoma U2OS and MG-63 Cells' Migration and Invasion in Culture by Inhibition of uPA via the JAK/STAT Signaling Pathway.

Fisetin Promotes Functional Recovery after Spinal Cord Injury by Inhibiting Microglia/Macrophage M1 Polarization and JAK2/STAT3 Signaling Pathway.

Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.

Banxia xiexin decoction affects drug sensitivity in gastric cancer cells by regulating MGMT expression via IL‑6/JAK/STAT3‑mediated PD‑L1 activity.

A Potential Nutraceutical Candidate Lactucin Inhibits Adipogenesis through Downregulation of JAK2/STAT3 Signaling Pathway-Mediated Mitotic Clonal Expansion.

Piperlongumine loaded PLGA nanoparticles inhibit cancer stem-like cells through modulation of STAT3 in mammosphere model of triple negative breast cancer.

Thymosin α1 suppresses migration and invasion of PD-L1 high-expressing non-small-cell lung cancer cells via inhibition of STAT3-MMP2 signaling.