Colivelin ameliorates amyloid β peptide-induced impairments in spatial memory, synaptic plasticity, and calcium homeostasis in rats.

Wu MN, Zhou LW, Wang ZJ, Han WN, Zhang J, Liu XJ, Tong JQ, Qi JS

Hippocampus30 Oct 2014Cited by 16 (Europe PMC)

PMID25332198DOI10.1002/hipo.22378PepBankPUB-25332198

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In rats, intrahippocampal injection of colivelin, a humanin derivative, prevented the deficits in spatial learning and memory caused by Aβ25-35 in the Morris water maze.
In plain wordsIn rats, colivelin, a humanin derivative, prevented the learning and memory problems that amyloid beta peptide caused.
Peptide
Humanin
Outcome
DecreaseAβ25-35-induced deficit in spatial learning and memory (Morris water maze)
Study
ratn: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
intrahippocampal injection of CLN (0.2 nmol) effectively prevented Aβ25-35 (4 nmol)-induced deficits in spatial learning and memory of rats in Morris water maze test
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2533219801
02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In rats, colivelin nearly completely prevented the suppression of in vivo hippocampal long term potentiation by Aβ25-35.
In plain wordsIn rats, colivelin, a humanin derivative, prevented amyloid beta peptide from suppressing a brain cell signal linked to memory.
Peptide
Humanin
Outcome
DecreaseAβ25-35-induced suppression of hippocampal long term potentiation
Study
ratn: not reported in source
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
the suppression of in vivo hippocampal long term potentiation (LTP) by Aβ25-35 was nearly completely prevented by CLN
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2533219802
03AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In rats, CLN prevented Aβ25-35-induced spatial learning deficits in the Morris water maze.
In plain wordsIn rats, CLN prevented Aβ25-35-induced spatial learning deficits.
Peptide
Colivelin
Outcome
IncreaseSpatial learning
Study
ratn: not reported in source
Aβ25-35-induced impairment
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Our results showed that intrahippocampal injection of CLN (0.2 nmol) effectively prevented Aβ25-35 (4 nmol)-induced deficits in spatial learning and memory of rats in Morris water maze test
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-2533219804
04AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In rats, CLN prevented Aβ25-35-induced spatial memory deficits in the Morris water maze.
In plain wordsIn rats, CLN prevented Aβ25-35-induced spatial memory deficits.
Peptide
Colivelin
Outcome
IncreaseSpatial memory
Study
ratn: not reported in source
Aβ25-35-induced impairment
Outcome group
Cognition and memory · Nervous system and cognition
Source sentences
Summary
Our results showed that intrahippocampal injection of CLN (0.2 nmol) effectively prevented Aβ25-35 (4 nmol)-induced deficits in spatial learning and memory of rats in Morris water maze test
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-2533219805
05AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism
In rats, CLN nearly completely prevented Aβ25-35-induced suppression of hippocampal long-term potentiation.
In plain wordsIn rats, CLN nearly completely prevented Aβ25-35-induced suppression of hippocampal long-term potentiation.
Peptide
Colivelin
Outcome
IncreaseHippocampal long-term potentiation
Study
ratn: not reported in source
Aβ25-35-induced impairment
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
the suppression of in vivo hippocampal long term potentiation (LTP) by Aβ25-35 was nearly completely prevented by CLN
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-2533219806
06LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome
In primary cultured hippocampal neurons, colivelin pretreatment inhibited the calcium overload that Aβ25-35 induced.
In plain wordsIn cells, colivelin, a humanin derivative, reduced the calcium overload that amyloid beta peptide caused in brain neurons.
Peptide
Humanin
Outcome
DecreaseAβ25-35-induced calcium overload
Study
ratn: not reported in source
primary cultured hippocampal neurons
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
in addition, CLN pretreatment also effectively inhibited Aβ25-35-induced calcium overload in primary cultured hippocampal neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-2533219803
07LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In primary cultured hippocampal neurons, CLN pretreatment inhibited Aβ25-35-induced calcium overload.
In plain wordsIn cells, CLN pretreatment inhibited Aβ25-35-induced calcium overload in primary hippocampal neurons.
Peptide
Colivelin
Outcome
DecreaseCalcium overload
Study
n: not reported in source
Primary cultured hippocampal neurons
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
in addition, CLN pretreatment also effectively inhibited Aβ25-35-induced calcium overload in primary cultured hippocampal neurons.
1 context sentence(design, population, supporting numbers)
Summary · context
In this study, we investigated the neuroprotective effects of Colivelin (CLN), a novel HN derivative, against Aβ by using behavioral test, in vivo electrophysiological recording, and intracellular calcium imaging.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-2533219807

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:32 UTC
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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