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Study · Not a test of the peptide alone · 2005

14 results

Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and in vivo.

Chiba T, Yamada M, Hashimoto Y, Sato M, Sasabe J, Kita Y, Terashita K, Aiso S, Nishimoto I, Matsuoka M

The Journal of neuroscience : the official journal of the Society for Neuroscience1 Nov 2005Cited by 71 (Europe PMC)

PMID16267233 (opens in a new tab)PMCIDPMC6725789 (opens in a new tab)DOI10.1523/jneurosci.3348-05.2005 (opens in a new tab)PepBankPUB-16267233
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study14

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone14

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In animals given repeated intracerebroventricular Abeta25-35 or Abeta1-42, intracerebroventricular Colivelin completely suppressed the impairment in spatial working memory.

    In plain wordsIn animal tests, Colivelin given into the brain fully prevented the memory impairment caused by Abeta injections.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta-induced impairment of spatial working memory
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    intracerebroventricular administration of Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Abeta25-35 or Abeta1-42
    1 context sentence
    Summary · context
    To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In animals given a hippocampal injection of Abeta1-42, intracerebroventricular Colivelin antagonized neuronal loss in the CA1 region of the hippocampus.

    In plain wordsIn animal tests, Colivelin given into the brain reduced the loss of nerve cells in a memory region caused by Abeta1-42.

    Peptide
    Humanin
    Outcome
    DecreaseAbeta1-42-induced neuronal loss in hippocampal CA1
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Abeta1-42
    1 context sentence
    Summary · context
    To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In animals given the muscarinic receptor antagonist 3-quinuclidinyl benzilate, intraperitoneal Colivelin suppressed memory impairment.

    In plain wordsIn animal tests, Colivelin given by injection into the abdomen reduced memory problems caused by a drug that blocks acetylcholine receptors.

    Peptide
    Humanin
    Outcome
    DecreaseMemory impairment caused by 3-quinuclidinyl benzilate
    Study

    n: not reported in source

    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    intraperitoneally administered Colivelin suppresses memory impairment caused by a muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzilate
    1 context sentence
    Summary · context
    To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In animals, intracerebroventricular Colivelin completely suppressed spatial working memory impairment induced by repeated intracerebroventricular Abeta25-35.

    In plain wordsIn animals, Colivelin completely suppressed spatial working memory impairment induced by repeated intracerebroventricular Abeta25-35.

    Peptide
    Colivelin
    Outcome
    IncreaseSpatial working memory after Abeta25-35
    Study

    n: not reported in source

    Abeta25-35-induced spatial working memory impairment
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In vivo animal studies have further indicated that intracerebroventricular administration of Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Abeta25-35 or Abeta1-42

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  5. 05AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In animals, intracerebroventricular Colivelin completely suppressed spatial working memory impairment induced by repeated intracerebroventricular Abeta1-42.

    In plain wordsIn animals, Colivelin completely suppressed spatial working memory impairment induced by repeated intracerebroventricular Abeta1-42.

    Peptide
    Colivelin
    Outcome
    IncreaseSpatial working memory after Abeta1-42
    Study

    n: not reported in source

    Abeta1-42-induced spatial working memory impairment
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In vivo animal studies have further indicated that intracerebroventricular administration of Colivelin not only completely suppresses impairment in spatial working memory induced by repetitive intracerebroventricular injection of Abeta25-35 or Abeta1-42

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  6. 06AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In animals, Colivelin antagonized CA1 hippocampal neuronal loss induced by hippocampal Abeta1-42 injection.

    In plain wordsIn animals, Colivelin reduced CA1 hippocampal neuron loss induced by hippocampal Abeta1-42 injection.

    Peptide
    Colivelin
    Outcome
    DecreaseCA1 hippocampal neuronal loss
    Study

    n: not reported in source

    Hippocampal Abeta1-42 injection
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    but also it antagonizes neuronal loss in the CA1 region of hippocampus induced by hippocampal injection of Abeta1-42.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  7. 07AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In animals, intraperitoneal Colivelin suppressed memory impairment caused by 3-quinuclidinyl benzilate.

    In plain wordsIn animals, Colivelin suppressed memory impairment caused by 3-quinuclidinyl benzilate.

    Peptide
    Colivelin
    Outcome
    DecreaseMemory impairment after muscarinic receptor blockade
    Study

    n: not reported in source

    3-quinuclidinyl benzilate-induced memory impairment
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In addition, intraperitoneally administered Colivelin suppresses memory impairment caused by a muscarinic acetylcholine receptor antagonist, 3-quinuclidinyl benzilate

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  8. 08LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In neuronal cell tests, the hybrid peptide Colivelin completely suppressed death induced by overexpressed familial AD genes and Abeta1-43 at 100 fM.

    In plain wordsIn cells, the hybrid peptide Colivelin fully blocked nerve cell death caused by Alzheimer's-related insults at 100 fM.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal death induced by FAD-causative genes and Abeta1-43 (Colivelin)
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Concentration for complete suppression
    100 fM
    Colivelin

    Source sentences

    Summary
    Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Abeta1-43 at a concentration of 100 fM
    1 context sentence
    Summary · context
    To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  9. 09LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In neuronal cell tests, the humanin derivative AGA-(C8R)HNG17 suppressed death induced by overexpressed familial AD genes and Abeta1-43 at 10 pM.

    In plain wordsIn cells, a humanin derivative blocked nerve cell death caused by Alzheimer's-related insults, but needed a higher concentration (10 pM) than Colivelin.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal death induced by FAD-causative genes and Abeta1-43 (AGA-(C8R)HNG17)
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Concentration for complete suppression
    10 pM
    AGA-(C8R)HNG17

    Source sentences

    Summary
    whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM.
    1 context sentence
    Summary · context
    To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  10. 10LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    In neuronal cell tests, Colivelin neuroprotection occurred via two pathways: Ca2+/calmodulin-dependent protein kinase IV (triggered by ADNF) and STAT3 (triggered by HN).

    In plain wordsIn cells, Colivelin protected nerve cells through two separate signalling pathways.

    Peptide
    Humanin
    Outcome
    Not applicableNeuroprotective pathways of Colivelin
    Study

    n: not reported in source

    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN.
    1 context sentence
    Summary · context
    To potentiate the neuroprotective effect of HN, we synthesized a hybrid peptide named Colivelin composed of activity-dependent neurotrophic factor (ADNF) C-terminally fused to AGA-(C8R)HNG17, a potent HN derivative.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  11. 11LabNot a test of Colivelin aloneIn vitro (cells)Efficacy outcome

    In cells, Colivelin completely suppressed FAD-gene-induced death at 100 fM, whereas AGA-(C8R)HNG17 did so at 10 pM.

    In plain wordsIn cells, Colivelin completely suppressed FAD-gene-induced death at 100 fM, compared with 10 pM for AGA-(C8R)HNG17.

    Peptide
    Colivelin
    Outcome
    DecreaseDeath induced by FAD-causative genes
    Study

    n: not reported in source

    Cells with overexpressed FAD-causative genes
    Comparator
    AGA-(C8R)HNG17 at 10 pM
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Active concentration
    100 fM
    Colivelin
    Active concentration
    10 pM
    AGA-(C8R)HNG17

    Source sentences

    Summary
    Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Abeta1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  12. 12LabNot a test of Colivelin aloneIn vitro (cells)Efficacy outcome

    In cells, Colivelin completely suppressed Abeta1-43-induced death at 100 fM, whereas AGA-(C8R)HNG17 did so at 10 pM.

    In plain wordsIn cells, Colivelin completely suppressed Abeta1-43-induced death at 100 fM, compared with 10 pM for AGA-(C8R)HNG17.

    Peptide
    Colivelin
    Outcome
    DecreaseAbeta1-43-induced death
    Study

    n: not reported in source

    Abeta1-43-induced cell death
    Comparator
    AGA-(C8R)HNG17 at 10 pM
    Outcome group
    Neuroprotection · Nervous system and cognition

    Measurements

    Active concentration
    100 fM
    Colivelin
    Active concentration
    10 pM
    AGA-(C8R)HNG17

    Source sentences

    Summary
    Colivelin completely suppresses death induced by overexpressed FAD-causative genes and Abeta1-43 at a concentration of 100 fM, whereas AGA-(C8R)HNG17 does so at a concentration of 10 pM.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  13. 13LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In lab tests, Colivelin neuroprotection involved a Ca2+/calmodulin-dependent protein kinase IV pathway triggered by its ADNF component.

    In plain wordsIn lab tests, Colivelin neuroprotection involved a pathway mediated by Ca2+/calmodulin-dependent protein kinase IV.

    Peptide
    Colivelin
    Outcome
    Not applicableCa2+/calmodulin-dependent protein kinase IV pathway
    Study

    n: not reported in source

    In vitro neuroprotection
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  14. 14LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In lab tests, Colivelin neuroprotection involved a STAT3 pathway triggered by its humanin component.

    In plain wordsIn lab tests, Colivelin neuroprotection involved a STAT3 pathway triggered by its humanin component.

    Peptide
    Colivelin
    Outcome
    Not applicableSTAT3 pathway
    Study

    n: not reported in source

    In vitro neuroprotection
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Colivelin-induced neuroprotection has been confirmed to occur via two neuroprotective pathways: one mediated by Ca2+/calmodulin-dependent protein kinase IV, triggered by ADNF, and one mediated by signal transducer and activator of transcription 3, triggered by HN.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

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