Skip to content

Study · Not a test of the peptide alone · 2022

21 results

Colivelin, a synthetic derivative of humanin, ameliorates endothelial injury and glycocalyx shedding after sepsis in mice.

Urban C, Hayes HV, Piraino G, Wolfe V, Lahni P, O'Connor M, Phares C, Zingarelli B

Frontiers in immunology2 Sept 2022Cited by 33 (Europe PMC)

PMID36119052 (opens in a new tab)PMCIDPMC9478210 (opens in a new tab)DOI10.3389/fimmu.2022.984298 (opens in a new tab)PepBankPUB-36119052
Download PDFPubMedAsk about this study
Jump to 21 results

Summary

Endothelial dysfunction plays a central role in the pathogenesis of sepsis-mediated multiple organ failure. Several clinical and experimental studies have suggested that the glycocalyx is an early target of endothelial injury during an infection. Colivelin, a synthetic derivative of the mitochondrial peptide humanin, has displayed cytoprotective effects in oxidative conditions. In the current study, we aimed to determine the potential therapeutic effects of colivelin in endothelial dysfunction and outcomes of sepsis in vivo. Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP. We observed that vehicle-treated mice had early elevation of plasma levels of the adhesion molecules ICAM-1 and P-selectin, the angiogenetic factor endoglin and the glycocalyx syndecan-1 at 6 h after CLP when compared to control mice, while levels of angiopoietin-2, a mediator of microvascular disintegration, and the proprotein convertase subtilisin/kexin type 9, an enzyme implicated in clearance of endotoxins, raised at 18 h after CLP. The early elevation of these endothelial and glycocalyx damage biomarkers coincided with lung histological injury and neutrophil inflammation in lung, liver, and kidneys. At transmission electron microscopy analysis, thoracic aortas of septic mice showed increased glycocalyx breakdown and shedding, and damaged mitochondria in endothelial and smooth muscle cells. Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10. These therapeutic effects of colivelin were associated with amelioration of glycocalyx density and mitochondrial structure in the aorta. At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung. In long-term outcomes studies up to 7 days, co-treatment of colivelin with antimicrobial agents significantly reduced the disease severity score when compared to treatment with antibiotics alone. In conclusion, our data support that damage of the glycocalyx is an early pathogenetic event during sepsis and that colivelin may have therapeutic potential for the treatment of sepsis-associated endothelial dysfunction.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study21

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone21

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin ameliorated lung architecture.

    In plain wordsIn septic mice, colivelin, a humanin derivative, improved lung structure.

    Peptide
    Humanin
    Outcome
    IncreaseLung architecture
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Infection and antimicrobial activity · Respiratory

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin reduced organ neutrophil infiltration.

    In plain wordsIn septic mice, colivelin, a humanin derivative, reduced neutrophil build-up in organs.

    Peptide
    Humanin
    Outcome
    DecreaseOrgan neutrophil infiltration
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin attenuated plasma syndecan-1 levels.

    In plain wordsIn septic mice, colivelin, a humanin derivative, lowered the blood level of syndecan-1, a vessel damage marker.

    Peptide
    Humanin
    Outcome
    DecreasePlasma syndecan-1
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin attenuated plasma tumor necrosis factor-α levels.

    In plain wordsIn septic mice, colivelin, a humanin derivative, lowered blood TNF-α, an inflammation marker.

    Peptide
    Humanin
    Outcome
    DecreasePlasma tumor necrosis factor-α
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin attenuated plasma macrophage inflammatory protein-1α levels.

    In plain wordsIn septic mice, colivelin, a humanin derivative, lowered blood MIP-1α, an inflammation marker.

    Peptide
    Humanin
    Outcome
    DecreasePlasma macrophage inflammatory protein-1α
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin attenuated plasma interleukin-10 levels.

    In plain wordsIn septic mice, colivelin, a humanin derivative, lowered blood interleukin-10.

    Peptide
    Humanin
    Outcome
    DecreasePlasma interleukin-10
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  7. 07AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin was associated with amelioration of glycocalyx density in the aorta.

    In plain wordsIn septic mice, colivelin, a humanin derivative, was linked to better glycocalyx density in the aorta.

    Peptide
    Humanin
    Outcome
    IncreaseAortic glycocalyx density
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    These therapeutic effects of colivelin were associated with amelioration of glycocalyx density and mitochondrial structure in the aorta.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  8. 08AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin was associated with amelioration of mitochondrial structure in the aorta.

    In plain wordsIn septic mice, colivelin, a humanin derivative, was linked to better mitochondrial structure in the aorta.

    Peptide
    Humanin
    Outcome
    IncreaseAortic mitochondrial structure
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    These therapeutic effects of colivelin were associated with amelioration of glycocalyx density and mitochondrial structure in the aorta.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  9. 09AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin treatment was associated with inhibition of STAT3 in the aorta and lung.

    In plain wordsIn septic mice, colivelin, a humanin derivative, was linked to lower STAT3 activity in the aorta and lung.

    Peptide
    Humanin
    Outcome
    DecreaseSTAT3 activity in aorta and lung
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  10. 10AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin treatment was associated with activation of AMP-activated protein kinase in the aorta and lung.

    In plain wordsIn septic mice, colivelin, a humanin derivative, was linked to higher AMPK activity in the aorta and lung.

    Peptide
    Humanin
    Outcome
    IncreaseAMPK activation in aorta and lung
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Vehicle
    Outcome group
    Receptor activity and mechanism · Immune and inflammation

    Source sentences

    Summary
    At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  11. 11AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice followed for up to 7 days, colivelin with antimicrobial agents reduced the disease severity score compared with antibiotics alone.

    In plain wordsIn septic mice, colivelin plus antibiotics lowered disease severity more than antibiotics alone.

    Peptide
    Humanin
    Outcome
    DecreaseDisease severity score up to 7 days
    Study

    mousen: not reported in source

    polymicrobial sepsis by cecal ligation and puncture
    Comparator
    Antibiotics alone
    Outcome group
    Infection and antimicrobial activity · Immune and inflammation

    Source sentences

    Summary
    In long-term outcomes studies up to 7 days, co-treatment of colivelin with antimicrobial agents significantly reduced the disease severity score when compared to treatment with antibiotics alone.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  12. 12AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin ameliorated lung architecture compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin improved lung structure compared with vehicle.

    Peptide
    Colivelin
    Outcome
    IncreaseLung architecture
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Lung injury and fibrosis · Respiratory

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  13. 13AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In septic mice, colivelin reduced organ neutrophil infiltration compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin reduced organ neutrophil infiltration compared with vehicle.

    Peptide
    Colivelin
    Outcome
    DecreaseOrgan neutrophil infiltration
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  14. 14AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin attenuated plasma syndecan-1 compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin reduced plasma syndecan-1 compared with vehicle.

    Peptide
    Colivelin
    Outcome
    DecreasePlasma syndecan-1
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  15. 15AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin attenuated plasma tumor necrosis factor-α compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin reduced plasma tumor necrosis factor-α compared with vehicle.

    Peptide
    Colivelin
    Outcome
    DecreasePlasma tumor necrosis factor-α
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  16. 16AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin attenuated plasma macrophage inflammatory protein-1α compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin reduced plasma macrophage inflammatory protein-1α compared with vehicle.

    Peptide
    Colivelin
    Outcome
    DecreasePlasma macrophage inflammatory protein-1α
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  17. 17AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin attenuated plasma interleukin-10 compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin reduced plasma interleukin-10 compared with vehicle.

    Peptide
    Colivelin
    Outcome
    DecreasePlasma interleukin-10
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Treatment with colivelin ameliorated lung architecture, reduced organ neutrophil infiltration, and attenuated plasma levels of syndecan-1, tumor necrosis factor-α, macrophage inflammatory protein-1α and interleukin-10.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  18. 18AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin was associated with ameliorated aortic glycocalyx density compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin was linked to improved aortic glycocalyx density compared with vehicle.

    Peptide
    Colivelin
    Outcome
    IncreaseAortic glycocalyx density
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Vascular function · Cardiovascular

    Source sentences

    Summary
    These therapeutic effects of colivelin were associated with amelioration of glycocalyx density and mitochondrial structure in the aorta.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  19. 19AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin was associated with ameliorated aortic mitochondrial structure compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin was linked to improved aortic mitochondrial structure compared with vehicle.

    Peptide
    Colivelin
    Outcome
    Not applicableAortic mitochondrial structure
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    These therapeutic effects of colivelin were associated with amelioration of glycocalyx density and mitochondrial structure in the aorta.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  20. 20AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin was associated with STAT3 inhibition in the aorta and lung compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin was linked to STAT3 inhibition in the aorta and lung compared with vehicle.

    Peptide
    Colivelin
    Outcome
    DecreaseSTAT3 inhibition in aorta and lung
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  21. 21AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In septic mice, colivelin was associated with AMPK activation in the aorta and lung compared with vehicle.

    In plain wordsIn mice with sepsis, colivelin was linked to AMPK activation in the aorta and lung compared with vehicle.

    Peptide
    Colivelin
    Outcome
    IncreaseAMPK activation in aorta and lung
    Study

    mousen: not reported in source

    C57BL/6 mice with cecal ligation and puncture
    Comparator
    vehicle
    Outcome group
    Receptor activity and mechanism · Whole body

    Source sentences

    Summary
    At molecular analysis, colivelin treatment was associated with inhibition of the signal transducer and activator of transcription 3 and activation of the AMP-activated protein kinase in the aorta and lung.
    1 context sentence
    Summary · context
    Male C57BL/6 mice were subjected to a clinically relevant model of polymicrobial sepsis by cecal ligation and puncture (CLP) and were treated with vehicle or colivelin (100-200 µg/kg) intraperitoneally at 1 h after CLP.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.