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Study · Not a test of the peptide alone · 2009

8 results

A novel peptide, colivelin, prevents alcohol-induced apoptosis in fetal brain of C57BL/6 mice: signaling pathway investigations.

Sari Y, Chiba T, Yamada M, Rebec GV, Aiso S

Neuroscience25 Sept 2009Cited by 18 (Europe PMC)

PMID19782727 (opens in a new tab)PMCIDPMC2783970 (opens in a new tab)DOI10.1016/j.neuroscience.2009.09.049 (opens in a new tab)PepBankPUB-19782727
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone8

In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Colivelin.

  1. 01AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In fetal mice, colivelin blocked the alcohol-induced decline in brain weight.

    In plain wordsIn fetal mice exposed to alcohol, colivelin preserved brain weight compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    IncreaseBrain weight
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    CLN blocked the alcohol-induced decline in brain weight

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  2. 02AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In fetal mice, colivelin prevented alcohol-induced apoptosis.

    In plain wordsIn fetal mice exposed to alcohol, colivelin prevented cell death compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    DecreaseApoptosis
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    CLN blocked the alcohol-induced decline in brain weight and prevented alcohol-induced: apoptosis,

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  3. 03AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In fetal mice, colivelin prevented alcohol-induced caspase-3 activation.

    In plain wordsIn fetal mice exposed to alcohol, colivelin prevented caspase-3 activation compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    DecreaseCaspase-3 activation
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    CLN blocked the alcohol-induced decline in brain weight and prevented alcohol-induced: apoptosis, activation of caspase-3

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  4. 04AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In fetal mice, colivelin prevented alcohol-induced increases in cytosolic cytochrome c.

    In plain wordsIn fetal mice exposed to alcohol, colivelin prevented increased cytosolic cytochrome c compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    DecreaseCytosolic cytochrome c
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    CLN blocked the alcohol-induced decline in brain weight and prevented alcohol-induced: apoptosis, activation of caspase-3 and increases of cytosolic cytochrome c,

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  5. 05AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In fetal mice, colivelin prevented alcohol-induced decreases in mitochondrial cytochrome c.

    In plain wordsIn fetal mice exposed to alcohol, colivelin prevented decreased mitochondrial cytochrome c compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    IncreaseMitochondrial cytochrome c
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Mitochondrial function · Nervous system and cognition

    Source sentences

    Summary
    CLN blocked the alcohol-induced decline in brain weight and prevented alcohol-induced: apoptosis, activation of caspase-3 and increases of cytosolic cytochrome c, and decreases of mitochondrial cytochrome c

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  6. 06AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In fetal mice exposed to alcohol, colivelin reduced c-Jun N-terminal kinase phosphorylation.

    In plain wordsIn fetal mice exposed to alcohol, colivelin reduced c-Jun N-terminal kinase phosphorylation compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    Decreasec-Jun N-terminal kinase phosphorylation
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Analysis of proteins in the upstream signaling pathway revealed that CLN down-regulated the phosphorylation of the c-Jun N-terminal kinase.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  7. 07AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In fetal mice, colivelin prevented alcohol-induced reduction in BAD phosphorylation.

    In plain wordsIn fetal mice exposed to alcohol, colivelin prevented decreased BAD phosphorylation compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    IncreaseBAD phosphorylation
    Study

    C57BL/6 micen: not reported in source

    fetal alcohol exposure
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Moreover, CLN prevented alcohol-induced reduction in phosphorylation of BAD protein.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  8. 08LabNot a test of Colivelin aloneIn vitro (cells)Efficacy outcome

    In primary cortical neurons exposed to alcohol, colivelin enhanced viability.

    In plain wordsIn cells exposed to alcohol, colivelin increased survival compared with alcohol exposure without colivelin.

    Peptide
    Colivelin
    Outcome
    IncreaseNeuronal viability
    Study

    n: not reported in source

    primary cortical neurons exposed to alcohol
    Comparator
    Alcohol exposure without colivelin
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Our initial experiment revealed that CLN enhanced the viability of primary cortical neurons exposed to alcohol.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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