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Study · Not a test of the peptide alone · 2025

3 results

Ghrelin ameliorates sepsis-induced acute skeletal muscle wasting via hypothalamic JAK2/STAT3-AgRP pathway.

Duan K, Li D, Chen T, Li W, Sun X, Gu L, Wang P, Gao X, Zhou J

International journal of surgery (London, England)20 Jun 2025Cited by 4 (Europe PMC)

PMID40552863 (opens in a new tab)PMCIDPMC12430764 (opens in a new tab)DOI10.1097/js9.0000000000002724 (opens in a new tab)PepBankPUB-40552863
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Colivelin.

  1. 01AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In sham rats, hypothalamic pathway activation with the stated agonist colivelin evoked hypothalamic inflammation.

    In plain wordsIn rats, hypothalamic activation with the stated agonist colivelin produced hypothalamic inflammation.

    Peptide
    Colivelin
    Outcome
    IncreaseHypothalamic inflammation
    Study

    ratn: not reported in source

    sham subjects
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Of note, activate hypothalamic JAK2/STAT3 pathway evoked hypothalamic inflammation and neuropeptides alteration, as well as muscle wasting in sham subjects.
    2 context sentences
    Summary · context
    Cecal ligation and puncture (CLP) was used to establish the model of sepsis-induced acute skeletal muscle wasting in rats.
    Summary · context
    Regulated AgRP expression by adenovirus vector approach and modulated hypothalamic JAK2/STAT3 activation by AG490 and colivelin injection were employed to study their role on muscle wasting.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  2. 02AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In sham rats, hypothalamic pathway activation with the stated agonist colivelin altered neuropeptides.

    In plain wordsIn rats, hypothalamic activation with the stated agonist colivelin altered neuropeptides.

    Peptide
    Colivelin
    Outcome
    Direction not reportedHypothalamic neuropeptides
    Study

    ratn: not reported in source

    sham subjects
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    Of note, activate hypothalamic JAK2/STAT3 pathway evoked hypothalamic inflammation and neuropeptides alteration, as well as muscle wasting in sham subjects.
    2 context sentences
    Summary · context
    Cecal ligation and puncture (CLP) was used to establish the model of sepsis-induced acute skeletal muscle wasting in rats.
    Summary · context
    Regulated AgRP expression by adenovirus vector approach and modulated hypothalamic JAK2/STAT3 activation by AG490 and colivelin injection were employed to study their role on muscle wasting.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  3. 03AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In sham rats, hypothalamic pathway activation with the stated agonist colivelin evoked muscle wasting.

    In plain wordsIn rats, hypothalamic activation with the stated agonist colivelin produced muscle wasting.

    Peptide
    Colivelin
    Outcome
    IncreaseMuscle wasting
    Study

    ratn: not reported in source

    sham subjects
    Outcome group
    Muscle injury and repair · Musculoskeletal

    Source sentences

    Summary
    Of note, activate hypothalamic JAK2/STAT3 pathway evoked hypothalamic inflammation and neuropeptides alteration, as well as muscle wasting in sham subjects.
    2 context sentences
    Summary · context
    Cecal ligation and puncture (CLP) was used to establish the model of sepsis-induced acute skeletal muscle wasting in rats.
    Summary · context
    Regulated AgRP expression by adenovirus vector approach and modulated hypothalamic JAK2/STAT3 activation by AG490 and colivelin injection were employed to study their role on muscle wasting.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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