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Study · Not a test of the peptide alone · 2017

10 results

Colivelin Ameliorates Impairments in Cognitive Behaviors and Synaptic Plasticity in APP/PS1 Transgenic Mice.

Wu M, Shi H, He Y, Yuan L, Qu X, Zhang J, Wang Z, Cai H, Qi J

Journal of Alzheimer's disease : JAD1 Jan 2017Cited by 17 (Europe PMC)

PMID28731445 (opens in a new tab)DOI10.3233/jad-170307 (opens in a new tab)PepBankPUB-28731445
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone10

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, colivelin pretreatment prevented the impairment in new object recognition.

    In plain wordsIn Alzheimer's model mice, the humanin derivative colivelin prevented a decline in object recognition.

    Peptide
    Humanin
    Outcome
    IncreaseNew object recognition
    Study

    mousen: not reported in source

    9-month-old APPswe/PS1dE9 (APP/PS1) Alzheimer's disease mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    1 context sentence
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, colivelin pretreatment prevented the impairment in working memory.

    In plain wordsIn Alzheimer's model mice, the humanin derivative colivelin prevented a decline in working memory.

    Peptide
    Humanin
    Outcome
    IncreaseWorking memory
    Study

    mousen: not reported in source

    9-month-old APPswe/PS1dE9 (APP/PS1) Alzheimer's disease mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    1 context sentence
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, colivelin pretreatment prevented the impairment in long-term spatial memory.

    In plain wordsIn Alzheimer's model mice, the humanin derivative colivelin prevented a decline in long-term spatial memory.

    Peptide
    Humanin
    Outcome
    IncreaseLong-term spatial memory
    Study

    mousen: not reported in source

    9-month-old APPswe/PS1dE9 (APP/PS1) Alzheimer's disease mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    1 context sentence
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In APP/PS1 mice, colivelin pretreatment reversed the depression of in vivo hippocampal LTP.

    In plain wordsIn Alzheimer's model mice, the humanin derivative colivelin reversed a loss of the brain signal linked to memory formation.

    Peptide
    Humanin
    Outcome
    IncreaseIn vivo hippocampal long-term potentiation (LTP)
    Study

    mousen: not reported in source

    9-month-old APPswe/PS1dE9 (APP/PS1) Alzheimer's disease mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    1 context sentence
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  5. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    In APP/PS1 mice, chronic colivelin application reduced Aβ deposition in the hippocampus.

    In plain wordsIn Alzheimer's model mice, the humanin derivative colivelin reduced amyloid-β deposits in the hippocampus.

    Peptide
    Humanin
    Outcome
    DecreaseHippocampal Aβ deposition
    Study

    mousen: not reported in source

    9-month-old APPswe/PS1dE9 (APP/PS1) Alzheimer's disease mice
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Additionally, chronic application of CLN obviously reduced Aβ deposition in the hippocampus in APP/PS1 mice.
    1 context sentence
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  6. 06AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, CLN pretreatment prevented impairments in new object recognition.

    In plain wordsIn mice with APP/PS1 mutations, CLN pretreatment prevented impaired recognition of new objects.

    Peptide
    Colivelin
    Outcome
    IncreaseNew object recognition
    Study

    mousen: not reported in source

    APPswe/PS1dE9 mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    2 context sentences
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.
    Summary · context
    The electrophysiological mechanism of CLN neuroprotection was also investigated by recording in vivo hippocampal long-term potentiation (LTP).

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  7. 07AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, CLN pretreatment prevented working memory impairments.

    In plain wordsIn mice with APP/PS1 mutations, CLN pretreatment prevented working memory impairments.

    Peptide
    Colivelin
    Outcome
    IncreaseWorking memory
    Study

    mousen: not reported in source

    APPswe/PS1dE9 mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    2 context sentences
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.
    Summary · context
    The electrophysiological mechanism of CLN neuroprotection was also investigated by recording in vivo hippocampal long-term potentiation (LTP).

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  8. 08AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In APP/PS1 mice, CLN pretreatment prevented long-term spatial memory impairments.

    In plain wordsIn mice with APP/PS1 mutations, CLN pretreatment prevented long-term spatial memory impairments.

    Peptide
    Colivelin
    Outcome
    IncreaseLong-term spatial memory
    Study

    mousen: not reported in source

    APPswe/PS1dE9 mice
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    2 context sentences
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.
    Summary · context
    The electrophysiological mechanism of CLN neuroprotection was also investigated by recording in vivo hippocampal long-term potentiation (LTP).

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  9. 09AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In APP/PS1 mice, CLN pretreatment reversed depression of hippocampal long-term potentiation in vivo.

    In plain wordsIn mice with APP/PS1 mutations, CLN pretreatment reversed reduced hippocampal long-term potentiation.

    Peptide
    Colivelin
    Outcome
    IncreaseHippocampal long-term potentiation
    Study

    mousen: not reported in source

    APPswe/PS1dE9 mice
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    CLN pretreatment effectively prevented impairments in new object recognition, working memory, and long-term spatial memory and reversed the depression of in vivo hippocampal LTP in APP/PS1 mice.
    2 context sentences
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.
    Summary · context
    The electrophysiological mechanism of CLN neuroprotection was also investigated by recording in vivo hippocampal long-term potentiation (LTP).

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  10. 10AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In APP/PS1 mice, chronic CLN application reduced hippocampal Aβ deposition.

    In plain wordsIn mice with APP/PS1 mutations, chronic CLN reduced hippocampal Aβ deposition.

    Peptide
    Colivelin
    Outcome
    DecreaseHippocampal Aβ deposition
    Study

    mousen: not reported in source

    APPswe/PS1dE9 mice
    Outcome group
    Neuroprotection · Nervous system and cognition

    Source sentences

    Summary
    Additionally, chronic application of CLN obviously reduced Aβ deposition in the hippocampus in APP/PS1 mice.
    2 context sentences
    Summary · context
    Here, we further observed the effects of chronically intranasally (i.n.) administered CLN on cognitive behaviors and pathological hallmarks in 9-month-old APPswe/PS1dE9 (APP/PS1) AD mice using multiple behavioral tests and immunochemistry.
    Summary · context
    The electrophysiological mechanism of CLN neuroprotection was also investigated by recording in vivo hippocampal long-term potentiation (LTP).

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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