Saikosaponin A alleviates glycolysis of breast cancer cells through repression of Akt/STAT3 pathway.

Zhang Y, Dai K, Xu D, Fan H, Ji N, Wang D, Zhao Y, Liu R

Chemical biology & drug design23 Apr 2023Cited by 13 (Europe PMC)

PMID37088850DOI10.1111/cbdd.14259PepBankPUB-37088850

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Colivelin.

01LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin increased cell viability.
In plain wordsIn cells from breast cancer, colivelin increased cell viability.
Peptide
Colivelin
Outcome
IncreaseCell viability
Study
n: not reported in source
breast cancer cells
Outcome group
Cell viability and death · Cancer
Source sentences
Summary
Colivelin boosted the BC cell viability and proliferation and impeded apoptosis
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885001
02LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin increased proliferation.
In plain wordsIn cells from breast cancer, colivelin increased proliferation.
Peptide
Colivelin
Outcome
IncreaseCell proliferation
Study
n: not reported in source
breast cancer cells
Outcome group
Tumor growth · Cancer
Source sentences
Summary
Colivelin boosted the BC cell viability and proliferation and impeded apoptosis
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885002
03LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin impeded apoptosis.
In plain wordsIn cells from breast cancer, colivelin reduced programmed cell death.
Peptide
Colivelin
Outcome
DecreaseApoptosis
Study
n: not reported in source
breast cancer cells
Outcome group
Cell viability and death · Cancer
Source sentences
Summary
Colivelin boosted the BC cell viability and proliferation and impeded apoptosis
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885003
04LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin increased lactate content.
In plain wordsIn cells from breast cancer, colivelin increased lactate content.
Peptide
Colivelin
Outcome
IncreaseLactate content
Study
n: not reported in source
breast cancer cells
Outcome group
Metabolic pathways and metabolomics · Cancer
Source sentences
Summary
Meanwhile, colivelin intensified lactate and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers level in BC cells
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885004
05LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin increased ATP content.
In plain wordsIn cells from breast cancer, colivelin increased ATP content.
Peptide
Colivelin
Outcome
IncreaseATP content
Study
n: not reported in source
breast cancer cells
Outcome group
Metabolic pathways and metabolomics · Cancer
Source sentences
Summary
Meanwhile, colivelin intensified lactate and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers level in BC cells
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885005
06LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin increased glucose uptake.
In plain wordsIn cells from breast cancer, colivelin increased glucose uptake.
Peptide
Colivelin
Outcome
IncreaseGlucose uptake
Study
n: not reported in source
breast cancer cells
Outcome group
Metabolic pathways and metabolomics · Cancer
Source sentences
Summary
Meanwhile, colivelin intensified lactate and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers level in BC cells
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885006
07LabNot a test of Colivelin aloneIn vitro (cells)Mechanism
In breast cancer cells, colivelin increased Akt/STAT3 pathway-related marker levels.
In plain wordsIn cells from breast cancer, colivelin increased Akt/STAT3 pathway-related marker levels.
Peptide
Colivelin
Outcome
IncreaseAkt/STAT3 pathway-related markers
Study
n: not reported in source
breast cancer cells
Outcome group
Receptor activity and mechanism · Cancer
Source sentences
Summary
Meanwhile, colivelin intensified lactate and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers level in BC cells
1 context sentence(design, population, supporting numbers)
Summary · context
The biological behaviors, lactate, and ATP contents, glucose uptake, and Akt/STAT3 pathway-related markers in BC cells treated with colivelin or SSA were evaluated using cell function experiments, kit, and Western blot.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3708885007

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

Keywords

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