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Study · Not a test of the peptide alone · 2021

5 results

PM2.5 promoted lipid accumulation in macrophage via inhibiting JAK2/STAT3 signaling pathways and aggravating the inflammatory reaction.

Yang L, Song Z, Pan Y, Zhao T, Shi Y, Xing J, Ju A, Zhou L, Ye L

Ecotoxicology and environmental safety5 Oct 2021Cited by 18 (Europe PMC)

PMID34624536 (opens in a new tab)DOI10.1016/j.ecoenv.2021.112872 (opens in a new tab)PepBankPUB-34624536
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Colivelin.

  1. 01LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In PM-exposed macrophages, colivelin TFA significantly reduced the induced increase in triglyceride levels.

    In plain wordsIn lab tests, colivelin TFA reduced triglycerides compared with particulate matter exposure alone.

    Peptide
    Colivelin
    Outcome
    DecreaseTriglyceride levels
    Study

    n: not reported in source

    PM2.5-exposed THP-1-derived macrophages
    Comparator
    PM2.5 exposure without colivelin TFA
    Outcome group
    Lipids · Cardiovascular

    Source sentences

    Summary
    Colivelin TFA significantly decreased the increasing levels of TG, T-CHO and LDL-C levels, and increased the decreasing mRNA levels of IL-4, and LPL induced by PM2.5 (p < 0.05).
    2 context sentences
    Summary · context
    Macrophages derived from THP-1 cells were exposed to PM2.5 (0,100,200,400 μg/mL) for 6 h and 12 h.
    Summary · context
    STAT3 agonist ColivelinTFA is used to specifically excite STAT3.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  2. 02LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In PM-exposed macrophages, colivelin TFA significantly reduced the induced increase in total cholesterol levels.

    In plain wordsIn lab tests, colivelin TFA reduced total cholesterol compared with particulate matter exposure alone.

    Peptide
    Colivelin
    Outcome
    DecreaseTotal cholesterol levels
    Study

    n: not reported in source

    PM2.5-exposed THP-1-derived macrophages
    Comparator
    PM2.5 exposure without colivelin TFA
    Outcome group
    Lipids · Cardiovascular

    Source sentences

    Summary
    Colivelin TFA significantly decreased the increasing levels of TG, T-CHO and LDL-C levels, and increased the decreasing mRNA levels of IL-4, and LPL induced by PM2.5 (p < 0.05).
    2 context sentences
    Summary · context
    Macrophages derived from THP-1 cells were exposed to PM2.5 (0,100,200,400 μg/mL) for 6 h and 12 h.
    Summary · context
    STAT3 agonist ColivelinTFA is used to specifically excite STAT3.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  3. 03LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In PM-exposed macrophages, colivelin TFA significantly reduced the induced increase in LDL-C levels.

    In plain wordsIn lab tests, colivelin TFA reduced LDL-C compared with particulate matter exposure alone.

    Peptide
    Colivelin
    Outcome
    DecreaseLDL-C levels
    Study

    n: not reported in source

    PM2.5-exposed THP-1-derived macrophages
    Comparator
    PM2.5 exposure without colivelin TFA
    Outcome group
    Lipids · Cardiovascular

    Source sentences

    Summary
    Colivelin TFA significantly decreased the increasing levels of TG, T-CHO and LDL-C levels, and increased the decreasing mRNA levels of IL-4, and LPL induced by PM2.5 (p < 0.05).
    2 context sentences
    Summary · context
    Macrophages derived from THP-1 cells were exposed to PM2.5 (0,100,200,400 μg/mL) for 6 h and 12 h.
    Summary · context
    STAT3 agonist ColivelinTFA is used to specifically excite STAT3.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  4. 04LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In PM-exposed macrophages, colivelin TFA significantly increased the suppressed IL-4 mRNA levels.

    In plain wordsIn lab tests, colivelin TFA increased IL-4 mRNA compared with particulate matter exposure alone.

    Peptide
    Colivelin
    Outcome
    IncreaseIL-4 mRNA levels
    Study

    n: not reported in source

    PM2.5-exposed THP-1-derived macrophages
    Comparator
    PM2.5 exposure without colivelin TFA
    Outcome group
    Inflammation markers · Cardiovascular

    Source sentences

    Summary
    Colivelin TFA significantly decreased the increasing levels of TG, T-CHO and LDL-C levels, and increased the decreasing mRNA levels of IL-4, and LPL induced by PM2.5 (p < 0.05).
    2 context sentences
    Summary · context
    Macrophages derived from THP-1 cells were exposed to PM2.5 (0,100,200,400 μg/mL) for 6 h and 12 h.
    Summary · context
    STAT3 agonist ColivelinTFA is used to specifically excite STAT3.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  5. 05LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In PM-exposed macrophages, colivelin TFA significantly increased the suppressed LPL mRNA levels.

    In plain wordsIn lab tests, colivelin TFA increased LPL mRNA compared with particulate matter exposure alone.

    Peptide
    Colivelin
    Outcome
    IncreaseLPL mRNA levels
    Study

    n: not reported in source

    PM2.5-exposed THP-1-derived macrophages
    Comparator
    PM2.5 exposure without colivelin TFA
    Outcome group
    Receptor activity and mechanism · Cardiovascular

    Source sentences

    Summary
    Colivelin TFA significantly decreased the increasing levels of TG, T-CHO and LDL-C levels, and increased the decreasing mRNA levels of IL-4, and LPL induced by PM2.5 (p < 0.05).
    2 context sentences
    Summary · context
    Macrophages derived from THP-1 cells were exposed to PM2.5 (0,100,200,400 μg/mL) for 6 h and 12 h.
    Summary · context
    STAT3 agonist ColivelinTFA is used to specifically excite STAT3.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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