Colivelin Rescues Ischemic Neuron and Axons Involving JAK/STAT3 Signaling Pathway.

Zhao H, Feng Y, Wei C, Li Y, Ma H, Wang X, Cui Z, Jin WN, Shi FD

Neuroscience30 Jul 2019Cited by 33 (Europe PMC)

PMID31374230DOI10.1016/j.neuroscience.2019.07.020PepBankPUB-31374230

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone14

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with transient focal cerebral ischemia, Colivelin decreased neurological deficits versus vehicle.
In plain wordsIn mice with induced stroke, Colivelin reduced neurological deficits compared with vehicle.
Peptide
Humanin
Outcome
DecreaseNeurological deficits after brain ischemia
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
We found that relative to mice receiving vehicle, Colivelin administration decreased the neurological deficits and infarct lesion induced by brain ischemia.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423001
02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with transient focal cerebral ischemia, Colivelin decreased the infarct lesion versus vehicle.
In plain wordsIn mice with induced stroke, Colivelin reduced the size of the brain damage area compared with vehicle.
Peptide
Humanin
Outcome
DecreaseInfarct lesion after brain ischemia
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
We found that relative to mice receiving vehicle, Colivelin administration decreased the neurological deficits and infarct lesion induced by brain ischemia.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423002
03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with transient focal cerebral ischemia, Colivelin inhibited axonal damage in brain tissue.
In plain wordsIn mice with induced stroke, Colivelin reduced damage to nerve fibers in the brain.
Peptide
Humanin
Outcome
DecreaseAxonal damage in ischemic brain tissue
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423003
04AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with transient focal cerebral ischemia, Colivelin inhibited neuronal death in brain tissue.
In plain wordsIn mice with induced stroke, Colivelin reduced nerve cell death in the brain.
Peptide
Humanin
Outcome
DecreaseNeuronal death in ischemic brain tissue
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423004
05AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In mice with transient focal cerebral ischemia, Colivelin was associated with elevated anti-apoptotic gene expression in ischemic neurons.
In plain wordsIn mice with induced stroke, Colivelin was linked to higher expression of genes that block cell death in brain neurons.
Peptide
Humanin
Outcome
IncreaseAnti-apoptotic gene expression in ischemic neurons
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423005
06AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome
In mice with transient focal cerebral ischemia, Colivelin increased axonal growth up until two weeks post-stroke.
In plain wordsIn mice with induced stroke, Colivelin increased nerve fiber growth for up to two weeks.
Peptide
Humanin
Outcome
IncreaseAxonal growth up to two weeks post-stroke
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423006
07AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism
In mice with transient focal cerebral ischemia, Colivelin activated STAT3 signaling.
In plain wordsIn mice with induced stroke, Colivelin switched on STAT3 signaling in the brain.
Peptide
Humanin
Outcome
IncreaseSTAT3 signaling activation
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion in mice
Comparator
Vehicle
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, Colivelin activated STAT3 signaling, which may partially contribute to its beneficial effect against neuronal death and axon growth.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3137423007
08AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In mice with cerebral ischemia, colivelin decreased neurological deficits relative to vehicle.
In plain wordsIn mice with cerebral ischemia, colivelin reduced neurological deficits compared with vehicle.
Peptide
Colivelin
Outcome
DecreaseNeurological deficits
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Comparator
vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
We found that relative to mice receiving vehicle, Colivelin administration decreased the neurological deficits and infarct lesion induced by brain ischemia.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423008
09AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In mice with cerebral ischemia, colivelin decreased infarct lesion relative to vehicle.
In plain wordsIn mice with cerebral ischemia, colivelin reduced the infarct lesion compared with vehicle.
Peptide
Colivelin
Outcome
DecreaseInfarct lesion
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Comparator
vehicle
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
We found that relative to mice receiving vehicle, Colivelin administration decreased the neurological deficits and infarct lesion induced by brain ischemia.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423009
10AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In mice with cerebral ischemia, colivelin inhibited axonal damage in brain tissue.
In plain wordsIn mice with cerebral ischemia, colivelin reduced axonal damage in brain tissue.
Peptide
Colivelin
Outcome
DecreaseAxonal damage
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423010
11AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In mice with cerebral ischemia, colivelin inhibited neuronal death in brain tissue.
In plain wordsIn mice with cerebral ischemia, colivelin reduced neuronal death in brain tissue.
Peptide
Colivelin
Outcome
DecreaseNeuronal death
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423011
12AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism
In ischemic mouse neurons, colivelin was associated with elevated anti-apoptotic gene expression.
In plain wordsIn mice with cerebral ischemia, colivelin was linked to higher expression of genes that prevent cell death.
Peptide
Colivelin
Outcome
IncreaseAnti-apoptotic gene expression
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423012
13AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome
In mice with cerebral ischemia, colivelin was associated with increased axonal growth up until two-weeks post-stroke.
In plain wordsIn mice with cerebral ischemia, colivelin was linked to increased axonal growth up until two-weeks post-stroke.
Peptide
Colivelin
Outcome
IncreaseAxonal growth
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
Colivelin inhibited axonal damage and neuronal death in brain tissue, which was associated with elevated anti-apoptotic gene expression in ischemic neurons as well as increased axonal growth up until two-weeks post-stroke.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423013
14AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism
In mice with cerebral ischemia, colivelin activated STAT3 signaling.
In plain wordsIn mice with cerebral ischemia, colivelin activated STAT3 signaling.
Peptide
Colivelin
Outcome
IncreaseSTAT3 signaling
Study
mousen: not reported in source
Transient focal cerebral ischemia and reperfusion
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Source sentences
Summary
Moreover, Colivelin activated STAT3 signaling, which may partially contribute to its beneficial effect against neuronal death and axon growth.
1 context sentence(design, population, supporting numbers)
Summary · context
We adopted 60 min induction of transient focal cerebral ischemia and reperfusion in mice.
In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.
Report a problemFND-3137423014

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 16:32 UTC
Study data updated · source update from Europe PMC
Version 2
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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