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Study · Not a test of the peptide alone · 2024

3 results

Dendrobine regulates STAT3 to attenuate mitochondrial dysfunction and senescence in vascular endothelial cells triggered by oxidized low-density lipoprotein.

Xia J, Chen J, Xing X, Meng J, Song X, Lou D

Drug development research1 Feb 2024Cited by 11 (Europe PMC)

PMID38349255 (opens in a new tab)DOI10.1002/ddr.22152 (opens in a new tab)PepBankPUB-38349255
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Colivelin.

  1. 01LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In HUVEC experiments, colivelin treatment decreased cell viability.

    In plain wordsIn cells, colivelin treatment decreased cell viability.

    Peptide
    Colivelin
    Outcome
    DecreaseCell viability
    Study

    humann: not reported in source

    ox-LDL-treated HUVECs
    Outcome group
    Cell viability and death · Cardiovascular

    Source sentences

    Summary
    Both Mdivi-1 and colivelin treatments resulted in decreased cell viability and increased cellular senescence
    2 context sentences
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL) to mimic AS, and the effects of dendrobine on cell viability, lipid deposition, mitochondrial function, and cellular senescence were evaluated.
    Summary · context
    Subsequently, cells were treated with the mitophagy inhibitor Mdivi-1 and the STAT3 agonist colivelin to assess the role of mitophagy and STAT3 signaling in dendrobine regulation.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  2. 02LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In HUVEC experiments, colivelin treatment increased cellular senescence.

    In plain wordsIn cells, colivelin treatment increased cellular senescence.

    Peptide
    Colivelin
    Outcome
    IncreaseCellular senescence
    Study

    humann: not reported in source

    ox-LDL-treated HUVECs
    Outcome group
    Aging markers · Cardiovascular

    Source sentences

    Summary
    Both Mdivi-1 and colivelin treatments resulted in decreased cell viability and increased cellular senescence
    2 context sentences
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL) to mimic AS, and the effects of dendrobine on cell viability, lipid deposition, mitochondrial function, and cellular senescence were evaluated.
    Summary · context
    Subsequently, cells were treated with the mitophagy inhibitor Mdivi-1 and the STAT3 agonist colivelin to assess the role of mitophagy and STAT3 signaling in dendrobine regulation.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  3. 03LabNot a test of Colivelin aloneIn vitro (cells)Mechanism

    In HUVEC experiments, colivelin suppressed mitophagy.

    In plain wordsIn cells, colivelin suppressed mitophagy.

    Peptide
    Colivelin
    Outcome
    DecreaseMitophagy
    Study

    humann: not reported in source

    ox-LDL-treated HUVECs
    Outcome group
    Mitochondrial function · Cardiovascular

    Source sentences

    Summary
    with colivelin suppressing mitophagy.
    2 context sentences
    Summary · context
    Human umbilical vein endothelial cells (HUVECs) were treated with oxidized low-density lipoprotein (ox-LDL) to mimic AS, and the effects of dendrobine on cell viability, lipid deposition, mitochondrial function, and cellular senescence were evaluated.
    Summary · context
    Subsequently, cells were treated with the mitophagy inhibitor Mdivi-1 and the STAT3 agonist colivelin to assess the role of mitophagy and STAT3 signaling in dendrobine regulation.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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