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Study · Not a test of the peptide alone · 2008

4 results

The multiple T-maze in vivo testing of the neuroprotective effect of humanin analogues.

Kunesová G, Hlavácek J, Patocka J, Evangelou A, Zikos C, Benaki D, Paravatou-Petsotas M, Pelecanou M, Livaniou E, Slaninova J

Peptides5 Jul 2008Cited by 33 (Europe PMC)

PMID18647630 (opens in a new tab)DOI10.1016/j.peptides.2008.06.019 (opens in a new tab)PepBankPUB-18647630
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats with QNB-induced memory impairment, truncated Humanin analogues and most tert-Leu analogues were devoid of activity in the multiple T-maze test.

    In plain wordsIn rats with induced memory problems, shortened Humanin-like peptides and most tert-Leu versions did not help.

    Peptide
    Humanin
    Outcome
    No significant changeSpatial memory after truncated and most tert-Leu Humanin analogues
    Study

    ratn: not reported in source

    QNB-induced spatial memory impairment, multiple T-maze
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    While the truncated analogues and most of the tert-Leu containing analogues were devoid of activity
    1 context sentence
    Summary · context
    This paper describes the activity of new peptides of the HN family, after i.p. administration, on QNB-induced impairment of spatial memory in the multiple T-maze test in rats.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats with QNB-induced memory impairment, analogues of the active Humanin core RG-PAGA reversed the spatial memory impairment irrespective of the number of Leu in their sequence.

    In plain wordsIn rats with induced memory problems, Humanin-core peptides reversed the memory impairment whatever their number of leucines.

    Peptide
    Humanin
    Outcome
    IncreaseSpatial memory after RG-PAGA Humanin analogues
    Study

    ratn: not reported in source

    QNB-induced spatial memory impairment, multiple T-maze
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    the analogues of the RG-PAGA were active, i.e. they reversed the impairment of spatial memory irrespective of the number of Leu present in their sequence.
    1 context sentence
    Summary · context
    This paper describes the activity of new peptides of the HN family, after i.p. administration, on QNB-induced impairment of spatial memory in the multiple T-maze test in rats.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 03AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In rats with QNB-induced memory impairment, colivelin and its des-Leu analogue showed the highest activity in the multiple T-maze test.

    In plain wordsIn rats with induced memory problems, colivelin and its des-Leu version worked best of the Humanin-like peptides tested.

    Peptide
    Humanin
    Outcome
    IncreaseSpatial memory after colivelin and its des-Leu analogue
    Study

    ratn: not reported in source

    QNB-induced spatial memory impairment, multiple T-maze
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    The highest activity was shown by colivelin and its des-Leu-analogue.
    1 context sentence
    Summary · context
    This paper describes the activity of new peptides of the HN family, after i.p. administration, on QNB-induced impairment of spatial memory in the multiple T-maze test in rats.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 04AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In rats with QNB-induced memory impairment, colivelin showed the highest activity among tested peptides, alongside its des-Leu analogue.

    In plain wordsIn rats with QNB-induced memory impairment, colivelin showed the highest activity among tested peptides, alongside its des-Leu analogue.

    Peptide
    Colivelin
    Outcome
    IncreaseActivity against spatial memory impairment
    Study

    ratn: not reported in source

    QNB-induced spatial memory impairment
    Comparator
    other tested humanin-family peptides
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    The highest activity was shown by colivelin and its des-Leu-analogue.
    1 context sentence
    Summary · context
    This paper describes the activity of new peptides of the HN family, after i.p. administration, on QNB-induced impairment of spatial memory in the multiple T-maze test in rats.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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