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Study · Not a test of the peptide alone · 2009

3 results

Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons.

Chiba T, Yamada M, Sasabe J, Terashita K, Shimoda M, Matsuoka M, Aiso S

Molecular psychiatry23 Sept 2008Cited by 179 (Europe PMC)

PMID18813209 (opens in a new tab)DOI10.1038/mp.2008.105 (opens in a new tab)PepBankPUB-18813209
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01AnimalNot a test of Humanin aloneAnimal study (in vivo)Efficacy outcome

    In Tg2576 Alzheimer's disease model mice, colivelin, a humanin derivative, completely restored cognitive function by activating the JAK2/STAT3 axis.

    In plain wordsIn mice, colivelin, a humanin derivative, fully restored memory function in an Alzheimer's model.

    Peptide
    Humanin
    Outcome
    IncreaseCognitive function
    Study

    mousen: not reported in source

    Tg2576 Alzheimer's disease model
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    We here report that an HN derivative named colivelin completely restored cognitive function in an AD model (Tg2576) by activating the JAK2/STAT3 axis.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 02AnimalNot a test of Colivelin aloneAnimal study (in vivo)Efficacy outcome

    In the Tg2576 AD model, colivelin completely restored cognitive function.

    In plain wordsIn mice with the Tg2576 AD model, colivelin completely restored cognitive function.

    Peptide
    Colivelin
    Outcome
    IncreaseCognitive function
    Study

    mousen: not reported in source

    Tg2576 Alzheimer's disease model
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    We here report that an HN derivative named colivelin completely restored cognitive function in an AD model (Tg2576) by activating the JAK2/STAT3 axis.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

  3. 03AnimalNot a test of Colivelin aloneAnimal study (in vivo)Mechanism

    In the Tg2576 AD model, colivelin activated the JAK2/STAT3 axis during restoration of cognitive function.

    In plain wordsIn mice with the Tg2576 AD model, colivelin activated JAK2/STAT3 signaling during restoration of cognitive function.

    Peptide
    Colivelin
    Outcome
    IncreaseJAK2/STAT3 activation
    Study

    mousen: not reported in source

    Tg2576 Alzheimer's disease model
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition

    Source sentences

    Summary
    We here report that an HN derivative named colivelin completely restored cognitive function in an AD model (Tg2576) by activating the JAK2/STAT3 axis.

    In this study, Colivelin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Colivelin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:32 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    13 Oct 2026, 21:44 UTC

    Study results updated

  3. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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