Histrelin

Three-letter sequence
L-pGlu-L-His-L-Trp-L-Ser-L-Tyr-1-benzyl-D-His-L-Leu-L-Arg-L-Pro-NHEt

InChIKey
HHXHVIJIIXKSOE-QILQGKCVSA-N

SMILES
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

• During histrelin treatment for advanced prostate cancer, 96.2% of patients reported adverse events. (BJU international, 2012)
• No significant adverse events occurred in children receiving histrelin implants. (The Journal of clinical endocrinology and metabolism, 2007)
• Minor implant site reactions occurred in 61% of children receiving histrelin. (International journal of pediatric endocrinology, 2009)
• In children receiving histrelin, the study observed no adverse effect on growth. (The Journal of clinical endocrinology and metabolism, 2015)
• In men with advanced prostate cancer, no testosterone surge occurred with histrelin reimplantation. (The Journal of urology, 2006)
• One man died of an unrelated cause 18 months after histrelin implant insertion. (The Journal of urology, 2000)
• In pediatric histrelin procedures, 14 complications occurred (0.8%). (The Journal of surgical research, 2023)
• In children, complications occurred in 1% of histrelin implant procedures. (Journal of pediatric surgery, 2019)
• In children with CPP, implant duration showed no link to breakage or a second incision. (Journal of pediatric endocrinology & metabolism, 2023)
• In prostate cancer patients receiving histrelin, 8 (7.1%) had minor, but not serious, adverse events. (Prostate cancer, 2014)
• In pediatric histrelin procedures, implant fracture or an additional incision occurred in 10 procedures (5%). (Journal of pediatric endocrinology & metabolism, 2021)
• In children, histrelin implant procedures occurred without significant difficulty. (The Journal of surgical research, 2015)
• In histrelin implant procedures for precocious puberty, difficulties occurred in 18 cases (16%). (Journal of pediatric surgery, 2014)
• In pediatric patients, 3/23 removed histrelin implants had breakage or difficult removal after an average 32.9 months. (Transgender health, 2023)
• In FDA adverse event reports, histrelin was linked to a greater tendency for psychiatric disorders than other long-acting GnRH drugs. (PloS one, 2025)
• In three girls with early puberty, histrelin implants broke during removal. (Hormone research in paediatrics, 2026)
• A physician survey reported 2 histrelin implant fractures, or 4% of reported fractures. (Journal of pediatric and adolescent gynecology, 2018)
• A child developed a sterile abscess twice after histrelin implant placement. (Clinical therapeutics, 2010)
• A boy with a retained histrelin implant returned with breast enlargement after being lost to follow-up. (Journal of the Endocrine Society, 2022)
• A patient with advanced prostate cancer developed liver injury after a histrelin implant. (Southern medical journal, 2010)
• In a girl with early puberty, menstrual periods remained absent approximately 68 months after histrelin implant placement. (Frontiers in endocrinology, 2026)
• Eight men died during histrelin treatment for advanced prostate cancer, with deaths judged unrelated to the drug. (BJU international, 2012)
• During histrelin treatment for advanced prostate cancer, serious adverse events were judged unrelated to the drug. (BJU international, 2012)
• Drug-related hot flashes affected 64.4% of men receiving histrelin for advanced prostate cancer, mostly mildly or moderately. (BJU international, 2012)

The doses that these studies used. They are not recommendations.