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Study · Case report or series · n = 1 · 2022

9 results

Gonadotropin Suppression for 7 Years After a Single Histrelin Implant for Precocious Puberty.

Villalta D, Quintos JB

Journal of the Endocrine Society7 Jan 2022Cited by 6 (Europe PMC)

PMID35047716 (opens in a new tab)PMCIDPMC8758400 (opens in a new tab)DOI10.1210/jendso/bvab189 (opens in a new tab)PepBankPUB-35047716
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. 9 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    In a boy with precocious puberty, prolonged histrelin suppression included random LH of 0.10 mIU/mL.

    In plain wordsIn a boy with precocious puberty, prolonged histrelin suppression included LH of 0.10 mIU/mL.

    Peptide
    Histrelin
    Outcome
    Not applicableLH during prolonged suppression
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Random LH
    0.1 mIU/mL
    single patient at return visit under continuous gonadotropin suppression

    Source sentences

    Summary
    He had continuous gonadotropin suppression with random LH 0.10 mIU/mL, FSH 0.16 mIU/mL, and testosterone 8 ng/dL.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  2. 02HumanCase report or seriesEfficacy outcome

    In a boy with precocious puberty, prolonged histrelin suppression included FSH of 0.16 mIU/mL.

    In plain wordsIn a boy with precocious puberty, prolonged histrelin suppression included FSH of 0.16 mIU/mL.

    Peptide
    Histrelin
    Outcome
    Not applicableFSH during prolonged suppression
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Random FSH
    0.16 mIU/mL
    single patient at return visit under continuous gonadotropin suppression

    Source sentences

    Summary
    He had continuous gonadotropin suppression with random LH 0.10 mIU/mL, FSH 0.16 mIU/mL, and testosterone 8 ng/dL.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  3. 03HumanCase report or seriesEfficacy outcome

    In a boy with precocious puberty, prolonged histrelin suppression included testosterone of 8 ng/dL.

    In plain wordsIn a boy with precocious puberty, prolonged histrelin suppression included testosterone of 8 ng/dL.

    Peptide
    Histrelin
    Outcome
    Not applicableTestosterone during prolonged suppression
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Testosterone
    8 ng/dL
    single patient at return visit under continuous gonadotropin suppression

    Source sentences

    Summary
    He had continuous gonadotropin suppression with random LH 0.10 mIU/mL, FSH 0.16 mIU/mL, and testosterone 8 ng/dL.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  4. 04HumanCase report or seriesSafety outcome

    A boy with a retained histrelin implant returned with gynecomastia after being lost to follow-up.

    In plain wordsA boy with a retained histrelin implant returned with breast enlargement after being lost to follow-up.

    Peptide
    Histrelin
    Outcome
    Not applicableGynecomastia
    Study

    n = 1

    Outcome group
    Adverse events · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The patient was lost to follow-up and returned 5 years later presenting with gynecomastia and delayed bone age.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  5. 05HumanCase report or seriesOther

    A boy with a retained histrelin implant returned with delayed bone age.

    In plain wordsA boy with a retained histrelin implant returned with delayed bone maturation.

    Peptide
    Histrelin
    Outcome
    Not applicableDelayed bone age
    Study

    n = 1

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The patient was lost to follow-up and returned 5 years later presenting with gynecomastia and delayed bone age.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  6. 06HumanCase report or seriesEfficacy outcome

    In a boy, LH was 5.6 mIU/mL four months after histrelin implant removal.

    In plain wordsIn a boy, LH was 5.6 mIU/mL after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    Not applicableLH after removal
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Random LH
    5.6 mIU/mL
    single patient, 4 months after implant removal

    Source sentences

    Summary
    The histrelin implant was removed, and 4 months later, his random pubertal hormone levels were LH 5.6 mIU/mL, FSH 4.3 mIU/mL, and testosterone 506 ng/dL.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  7. 07HumanCase report or seriesEfficacy outcome

    In a boy, FSH was 4.3 mIU/mL after histrelin implant removal.

    In plain wordsIn a boy, FSH was 4.3 mIU/mL after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    Not applicableFSH after removal
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Random FSH
    4.3 mIU/mL
    single patient, 4 months after implant removal

    Source sentences

    Summary
    The histrelin implant was removed, and 4 months later, his random pubertal hormone levels were LH 5.6 mIU/mL, FSH 4.3 mIU/mL, and testosterone 506 ng/dL.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  8. 08HumanCase report or seriesEfficacy outcome

    In a boy, testosterone was 506 ng/dL after histrelin implant removal.

    In plain wordsIn a boy, testosterone was 506 ng/dL after histrelin implant removal.

    Peptide
    Histrelin
    Outcome
    Not applicableTestosterone after removal
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Measurements

    Testosterone
    506 ng/dL
    single patient, 4 months after implant removal

    Source sentences

    Summary
    The histrelin implant was removed, and 4 months later, his random pubertal hormone levels were LH 5.6 mIU/mL, FSH 4.3 mIU/mL, and testosterone 506 ng/dL.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.
  9. 09HumanCase report or seriesEfficacy outcome

    After prolonged histrelin treatment, a boy's near final height was 170.6 cm, within 1 SD of mid-parental height of 175.3 cm.

    In plain wordsAfter prolonged histrelin treatment, a boy reached 170.6 cm, within 1 SD of his mid-parental height of 175.3 cm.

    Peptide
    Histrelin
    Outcome
    Not applicableNear final height
    Study

    n = 1

    Comparator
    Mid-parental height
    Outcome group
    Linear growth · Musculoskeletal
    Studied dose
    Dose not stated

    Measurements

    Near final height
    170.6 cm
    single patient
    Mid-parental height
    175.3 cm
    single patient (reference)
    Difference from genetic potential
    ≤ 1 SD
    single patient; reported as within 1 SD

    Source sentences

    Summary
    The patient's mid-parental height was 175.3 cm and his near final height was 170.6 cm, which is within 1 SD of his genetic potential.
    2 context sentences
    Summary · context
    A boy aged 10 years 3 months presented to the endocrine clinic with signs of precocious puberty and advanced bone age.
    Summary · context
    The patient was initially started on Lupron injections before transitioning to a histrelin implant.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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Terms as the source lists them.

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