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Study · Animal study (in vivo) · rat · 1987

6 results

Sensitivity differences in reproductive/endocrine organs to chronically administered LHRH agonists in female rats.

Phillips A, Hahn DW, Klimek S, McGuire JL, Crowley WF

Life sciences1 Apr 1987Cited by 3 (Europe PMC)

PMID3550346 (opens in a new tab)DOI10.1016/0024-3205(87)90328-6 (opens in a new tab)PepBankPUB-03550346
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, histrelin produced an initial stimulatory phase with increased serum LH on the first treatment day.

    In plain wordsIn rats, histrelin increased LH on the first treatment day.

    Peptide
    Histrelin
    Outcome
    IncreaseInitial LH response
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1, 10, 100 or 1000 micrograms/kg/day · injection · 1, 3, 5, 7, 11 or 28 daysAs given in this study (rat).

    Source sentences

    Summary
    An initial stimulatory phase was observed on the first day of treatment with substantial increases in serum LH and progesterone levels.
    3 context sentences
    Summary · context
    The responses observed with the two agonists were similar.
    Summary · context
    The acute and chronic effects of two LHRH agonists on reproductive endocrine target organs were examined in female rats.
    Summary · context
    Animals were injected twice daily with [(ImBzl)-D-His6,Pro9-NEt]LHRH (histrelin) or [D-Trp6,Pro9-NEt]LHRH for 1, 3, 5, 7, 11 or 28 days at 1, 10, 100 or 1000 micrograms/kg/day beginning in the luteal phase.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, histrelin produced an initial stimulatory phase with increased progesterone on the first treatment day.

    In plain wordsIn rats, histrelin increased progesterone on the first treatment day.

    Peptide
    Histrelin
    Outcome
    IncreaseInitial progesterone response
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1, 10, 100 or 1000 micrograms/kg/day · injection · 1, 3, 5, 7, 11 or 28 daysAs given in this study (rat).

    Source sentences

    Summary
    An initial stimulatory phase was observed on the first day of treatment with substantial increases in serum LH and progesterone levels.
    3 context sentences
    Summary · context
    The responses observed with the two agonists were similar.
    Summary · context
    The acute and chronic effects of two LHRH agonists on reproductive endocrine target organs were examined in female rats.
    Summary · context
    Animals were injected twice daily with [(ImBzl)-D-His6,Pro9-NEt]LHRH (histrelin) or [D-Trp6,Pro9-NEt]LHRH for 1, 3, 5, 7, 11 or 28 days at 1, 10, 100 or 1000 micrograms/kg/day beginning in the luteal phase.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In female rats receiving histrelin, hormone responses diminished significantly by day 3.

    In plain wordsIn rats receiving histrelin, hormone responses decreased significantly by day 3.

    Peptide
    Histrelin
    Outcome
    DecreaseHormone response at day 3
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1, 10, 100 or 1000 micrograms/kg/day · injection · 1, 3, 5, 7, 11 or 28 daysAs given in this study (rat).

    Source sentences

    Summary
    A significant diminution of hormone response was seen by day 3.
    3 context sentences
    Summary · context
    The responses observed with the two agonists were similar.
    Summary · context
    The acute and chronic effects of two LHRH agonists on reproductive endocrine target organs were examined in female rats.
    Summary · context
    Animals were injected twice daily with [(ImBzl)-D-His6,Pro9-NEt]LHRH (histrelin) or [D-Trp6,Pro9-NEt]LHRH for 1, 3, 5, 7, 11 or 28 days at 1, 10, 100 or 1000 micrograms/kg/day beginning in the luteal phase.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, only the 1000 micrograms/kg histrelin dose abolished the pituitary LH response at later treatment periods.

    In plain wordsIn rats, only the highest histrelin dose abolished the later pituitary LH response.

    Peptide
    Histrelin
    Outcome
    DecreasePituitary LH response at later periods
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1000 micrograms/kg/day · injection · 1, 3, 5, 7, 11 or 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Only 1000 micrograms/kg abolished the pituitary LH response at later treatment periods.
    3 context sentences
    Summary · context
    The responses observed with the two agonists were similar.
    Summary · context
    The acute and chronic effects of two LHRH agonists on reproductive endocrine target organs were examined in female rats.
    Summary · context
    Animals were injected twice daily with [(ImBzl)-D-His6,Pro9-NEt]LHRH (histrelin) or [D-Trp6,Pro9-NEt]LHRH for 1, 3, 5, 7, 11 or 28 days at 1, 10, 100 or 1000 micrograms/kg/day beginning in the luteal phase.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, histrelin doses as low as 1 microgram/kg/day decreased uterine weight.

    In plain wordsIn female rats, histrelin doses as low as 1 microgram/kg/day decreased uterine weight.

    Peptide
    Histrelin
    Outcome
    DecreaseUterine weight at low dose
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 microgram/kg/day · injection · 1, 3, 5, 7, 11 or 28 daysAs given in this study (rat).

    Source sentences

    Summary
    In contrast to the relatively high doses needed to inhibit the pituitary response and decrease ovarian weight, doses as low as 1 microgram/kg were sufficient to decrease uterine weight.
    3 context sentences
    Summary · context
    The responses observed with the two agonists were similar.
    Summary · context
    The acute and chronic effects of two LHRH agonists on reproductive endocrine target organs were examined in female rats.
    Summary · context
    Animals were injected twice daily with [(ImBzl)-D-His6,Pro9-NEt]LHRH (histrelin) or [D-Trp6,Pro9-NEt]LHRH for 1, 3, 5, 7, 11 or 28 days at 1, 10, 100 or 1000 micrograms/kg/day beginning in the luteal phase.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In female rats, histrelin inhibited estrous cyclicity, ovarian and uterine weight, and progesterone and estradiol levels with time and dose dependence.

    In plain wordsIn rats, histrelin inhibited reproductive cycles, ovarian and uterine weight, and progesterone and estradiol levels with time and dose dependence.

    Peptide
    Histrelin
    Outcome
    DecreaseTime- and dose-dependent reproductive inhibition
    Study

    ratn: not reported in source

    Female rats
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1, 10, 100 or 1000 micrograms/kg/day · injection twice daily · 1, 3, 5, 7, 11 or 28 daysAs given in this study (rat).

    Source sentences

    Summary
    Estrous cyclicity, ovarian and uterine weight, and progesterone and estradiol levels were inhibited in a time and dose dependent manner.
    2 context sentences
    Summary · context
    The responses observed with the two agonists were similar.
    Summary · context
    Animals were injected twice daily with [(ImBzl)-D-His6,Pro9-NEt]LHRH (histrelin) or [D-Trp6,Pro9-NEt]LHRH for 1, 3, 5, 7, 11 or 28 days at 1, 10, 100 or 1000 micrograms/kg/day beginning in the luteal phase.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

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