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Study · Observational study · n = 39 · 2021

1 result

Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty.

Wu V, Zhao V, Issa R, Wilkes M, Wallach E, Rapaport R, Romero C, Yau M

Annals of pediatric endocrinology & metabolism12 May 2021Cited by 11 (Europe PMC)

PMID34015904 (opens in a new tab)PMCIDPMC8505034 (opens in a new tab)DOI10.6065/apem.2040220.110 (opens in a new tab)PepBankPUB-34015904
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Summary

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Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. 1 result from people.

  1. 01HumanObservational studyEfficacy outcome

    In females with CPP, time to menarche after treatment showed no association with medication choice between histrelin and leuprolide.

    In plain wordsIn females with CPP, time to menarche after treatment showed no association with the choice of histrelin versus leuprolide.

    Peptide
    Histrelin
    Outcome
    No significant changeTime to menarche by medication
    Study

    n = 39

    Comparator
    Leuprolide
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    No association was seen between time interval to menarche and treatment duration, medication, or body mass index.
    1 context sentence
    Summary · context
    We retrospectively reviewed medical records of 39 females with CPP who reached menarche after GnRHa treatment (leuprolide or histrelin).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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