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Study · Animal study (in vivo) · equus asinus · 2019

8 results

Histrelin acetate-induced ovulation in Brazilian Northeastern jennies (Equus asinus) with different follicle diameters.

de Oliveira SN, Canuto L, Segabinazzi LGTM, Dell Aqua Junior JA, Papa P, Fonseca M, Ribeiro Filho AL, Papa F

Theriogenology20 Jun 2019Cited by 9 (Europe PMC)

PMID31254727 (opens in a new tab)DOI10.1016/j.theriogenology.2019.06.037 (opens in a new tab)PepBankPUB-31254727
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, histrelin at 29-32 mm follicles shortened the prostaglandin-to-ovulation interval versus control (145.2 ± 34.6 versus 220.0 ± 41.8 h).

    In plain wordsIn jennies, histrelin at 29-32 mm follicles shortened the time from prostaglandin to ovulation compared with control.

    Peptide
    Histrelin
    Outcome
    DecreaseProstaglandin-to-ovulation interval at 29-32 mm
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    control cycle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    Interval between prostaglandin administration and ovulation diagnosis was lower in jennies from T2 group (145.2 ± 34.6 h) compared with the control cycle (220.0 ± 41.8 h) and also with other treated cycles (T1 - 209.8 ± 48.0 h; T3 - 183.3 ± 33.9 h).
    2 context sentences
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, the prostaglandin-to-ovulation interval was shorter with histrelin in T2 than T1 (145.2 ± 34.6 versus 209.8 ± 48.0 h).

    In plain wordsIn jennies, histrelin at 29-32 mm follicles shortened the ovulation interval compared with treatment at 25-28 mm.

    Peptide
    Histrelin
    Outcome
    DecreaseProstaglandin-to-ovulation interval at 29-32 versus 25-28 mm
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    histrelin at 25-28 mm follicles
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    Interval between prostaglandin administration and ovulation diagnosis was lower in jennies from T2 group (145.2 ± 34.6 h) compared with the control cycle (220.0 ± 41.8 h) and also with other treated cycles (T1 - 209.8 ± 48.0 h; T3 - 183.3 ± 33.9 h).
    2 context sentences
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, the prostaglandin-to-ovulation interval was shorter with histrelin in T2 than T3 (145.2 ± 34.6 versus 183.3 ± 33.9 h).

    In plain wordsIn jennies, histrelin at 29-32 mm follicles shortened the ovulation interval compared with treatment at 33-36 mm.

    Peptide
    Histrelin
    Outcome
    DecreaseProstaglandin-to-ovulation interval at 29-32 versus 33-36 mm
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    histrelin at 33-36 mm follicles
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    Interval between prostaglandin administration and ovulation diagnosis was lower in jennies from T2 group (145.2 ± 34.6 h) compared with the control cycle (220.0 ± 41.8 h) and also with other treated cycles (T1 - 209.8 ± 48.0 h; T3 - 183.3 ± 33.9 h).
    2 context sentences
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, histrelin shortened the follicle-detection-to-ovulation interval in all treated cycle groups versus matched controls (P < 0.05).

    In plain wordsIn jennies, histrelin shortened the time from follicle detection to ovulation in all treated groups compared with matched controls.

    Peptide
    Histrelin
    Outcome
    DecreaseFollicle-detection-to-ovulation interval
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    matched control cycles
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    Histrelin acetate treatment also reduces the interval between detection of predetermined follicular size and ovulation (P < 0.05) in all treated cycles groups compared with matched control group.
    2 context sentences
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, ovulation induction success at 36-48 h was higher in all histrelin-treated groups than matched controls (P < 0.05).

    In plain wordsIn jennies, histrelin increased ovulation success at 36-48 h in all treated groups compared with matched controls.

    Peptide
    Histrelin
    Outcome
    IncreaseOvulation induction success at 36-48 h
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    matched control cycles
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    Higher percentage (P < 0.05) of jennies had success of ovulation induction (36-48 h after Histrelin acetate injection) in all treated cycles in contrast with the matched control group.
    2 context sentences
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, 100% in histrelin group T2 ovulated at 36-48 h, a higher proportion than T1 (P < 0.05).

    In plain wordsIn jennies, histrelin group T2 had more ovulations at 36-48 h than T1.

    Peptide
    Histrelin
    Outcome
    IncreaseOvulation at 36-48 h in T2 versus T1
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    T1
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    In addition, in comparison among treated cycle groups, more (P  0.05) from each other.
    2 context sentences
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, 100% in histrelin group T2 ovulated at 36-48 h, a higher proportion than T3 (P < 0.05).

    In plain wordsIn jennies, histrelin group T2 had more ovulations at 36-48 h than T3.

    Peptide
    Histrelin
    Outcome
    IncreaseOvulation at 36-48 h in T2 versus T3
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    T3
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    In addition, in comparison among treated cycle groups, more (P  0.05) from each other.
    2 context sentences
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In jennies, histrelin groups T1 and T3 did not differ in ovulation at 36-48 h (P > 0.05).

    In plain wordsIn jennies, histrelin groups T1 and T3 did not differ in ovulation at 36-48 h.

    Peptide
    Histrelin
    Outcome
    No significant changeOvulation at 36-48 h in T1 versus T3
    Study

    Equus asinusn = 10

    Brazilian Northeastern jennies
    Comparator
    T3
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · injectionAs given in this study (Equus asinus).

    Source sentences

    Summary
    In addition, in comparison among treated cycle groups, more (P  0.05) from each other.
    2 context sentences
    Summary · context
    Four consecutive estrus of 10 jennies were used in a crossover study
    Summary · context
    In treated cycle, jennies had the ovulation induced by 250 μg of Histrelin acetate (Strelin®, Botupharma, Botucatu, Brazil) when respective follicle diameters 25-28 mm (T1), 29-32 mm (T2) and 33-36 mm (T3) were diagnosed.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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