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Study · Case report or series · n = 3 · 2026

4 results

Prolonged Pubertal Suppression due to Retained Histrelin Implant in Three Children with Central Precocious Puberty.

Marpuri I, Geffner ME, Chao LC

Hormone research in paediatrics27 Feb 2025Cited by 2 (Europe PMC)

PMID40015262 (opens in a new tab)DOI10.1159/000544181 (opens in a new tab)PepBankPUB-40015262
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanCase report or seriesSafety outcome

    In three girls with central precocious puberty, histrelin implants broke during extraction.

    In plain wordsIn three girls with early puberty, histrelin implants broke during removal.

    Peptide
    Histrelin
    Outcome
    Direction not reportedImplant breakage
    Study

    n = 3

    Outcome group
    Adverse events · Reproductive and sexual health
    Studied dose
    Dose not stated · implantAs given in this study (human).

    Source sentences

    Summary
    We present 3 cases of females with central precocious puberty, who received HI for pubertal suppression and experienced implant breakage during extraction.
  2. 02HumanCase report or seriesSafety outcome

    In all three girls with central precocious puberty, menstruation occurred after surgical removal of histrelin implant fragments.

    In plain wordsIn all three girls with early puberty, menstrual periods occurred after removal of histrelin implant pieces.

    Peptide
    Histrelin
    Outcome
    Direction not reportedMenstruation after fragment removal
    Study

    n = 3

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · implantAs given in this study (human).

    Source sentences

    Summary
    In all 3 cases, menstruation occurred after the HI fragments were surgically removed.
    1 context sentence
    Summary · context
    We present 3 cases of females with central precocious puberty, who received HI for pubertal suppression and experienced implant breakage during extraction.
  3. 03HumanCase report or seriesActivity measurement

    In two girls with central precocious puberty, retained histrelin implant fragments suppressed pubertal hormones for five years.

    In plain wordsIn two girls with early puberty, retained histrelin implant pieces suppressed puberty hormones for five years.

    Peptide
    Histrelin
    Outcome
    DecreaseProlonged pubertal hormone suppression
    Study

    n = 2

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · implant · 5 yearsAs given in this study (human).

    Source sentences

    Summary
    In 2 cases, the retained fragment suppressed pubertal hormone for 5 years.
    1 context sentence
    Summary · context
    We present 3 cases of females with central precocious puberty, who received HI for pubertal suppression and experienced implant breakage during extraction.
  4. 04HumanCase report or seriesSafety outcome

    In one girl with central precocious puberty, a histrelin implant remained in place and amenorrhea persisted for six years.

    In plain wordsIn one girl with early puberty, menstrual periods remained absent for six years with a retained histrelin implant.

    Peptide
    Histrelin
    Outcome
    Direction not reportedAmenorrhea
    Study

    n = 1

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · implant · 6 yearsAs given in this study (human).

    Source sentences

    Summary
    In the third case, the HI was left in place due to loss of follow-up, and the patient was amenorrheic for the next 6 years.
    1 context sentence
    Summary · context
    We present 3 cases of females with central precocious puberty, who received HI for pubertal suppression and experienced implant breakage during extraction.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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