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Study · Animal study (in vivo) · macaca silenus · 2021

2 results

Effects of GnRH agonists on testosterone and testosterone-stimulated parameters for contraception and aggression reduction in male lion-tailed Macaques (Macaca silenus).

Penfold LM, Norton T, Asa CS

Zoo biology5 Jul 2021Cited by 4 (Europe PMC)

PMID34224162 (opens in a new tab)DOI10.1002/zoo.21635 (opens in a new tab)PepBankPUB-34224162
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male lion-tailed macaques, 100 mg histrelin could at least temporarily reduce testosterone.

    In plain wordsIn male lion-tailed macaques, 100 mg histrelin could at least temporarily reduce testosterone.

    Peptide
    Histrelin
    Outcome
    DecreaseTestosterone
    Study

    Macaca silenusn: not reported in source

    Male lion-tailed macaques
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    100 mgAs given in this study (Macaca silenus).

    Source sentences

    Summary
    Five trials at three institutions with 14 males demonstrated that 100 mg histrelin or 9 to 12 mg of deslorelin could at least temporarily reduce testosterone, but a lower 6 mg dose was ineffective.
    1 context sentence
    Summary · context
    This study investigated the effects of two GnRH agonists, histrelin and deslorelin, on testosterone, testis size, body weight and sperm production in male lion-tailed macaques, along with subjective observations of aggressive behavior.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male lion-tailed macaques, aggressive behavior decreased in every treated group except the lowest-dose deslorelin group, including the histrelin group.

    In plain wordsIn male lion-tailed macaques, aggression decreased in the histrelin group and all other treated groups except the lowest-dose deslorelin group.

    Peptide
    Histrelin
    Outcome
    DecreaseAggressive behavior
    Study

    Macaca silenusn: not reported in source

    Male lion-tailed macaques
    Outcome group
    Animal Behavior · Nervous system and cognition
    Studied dose
    100 mgAs given in this study (Macaca silenus).

    Source sentences

    Summary
    Aggressive behavior was reduced in all but the group receiving the lowest dose.
    2 context sentences
    Summary · context
    Five trials at three institutions with 14 males demonstrated that 100 mg histrelin or 9 to 12 mg of deslorelin could at least temporarily reduce testosterone, but a lower 6 mg dose was ineffective.
    Summary · context
    This study investigated the effects of two GnRH agonists, histrelin and deslorelin, on testosterone, testis size, body weight and sperm production in male lion-tailed macaques, along with subjective observations of aggressive behavior.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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