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Study · Animal study (in vivo) · horse · 2024

5 results

hCG versus histrelin acetate: ovulation inducing agents in mares (Equus caballus) in a commercial breeding program in Uruguay

Cazales N, Pereyra F, Icatt S, Colmán NJ, Camacho CA, Estradé MJ, Mattos RC

Journal of equine veterinary science1 Jun 2024

PepBankPUB-94699486
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Summary

The text of this summary is not shown here, because the article license does not allow reuse.

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mares, average response time did not differ significantly between histrelin (39.3 h) and hCG (37.2 h), P=0.2414.

    In plain wordsIn mares, average response time did not differ significantly between histrelin and hCG.

    Peptide
    Histrelin
    Outcome
    No significant changeAverage response time
    Study

    horsen: not reported in source

    Mares in a commercial breeding program
    Comparator
    hCG 1500 IU intravenously
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · intramuscularAs given in this study (horse).

    Measurements

    Average response time
    39.3 h
    histrelin; ±4.5
    Average response time
    37.2 h
    hCG; ±3.5

    Source sentences

    Summary
    There were no differences (P=0.2414) in the average response time between G1 (37.2h±3,5) and G2 (39.3h±4,5).
    2 context sentences
    Summary · context
    This study aimed to compare the efficacy of human chorionic gonadotrophin (hCG) and histrelin as ovulation inducers in young, adult, and old mares during spring and summer.
    Summary · context
    Cycles were randomly allotted in two groups; G1 (n=106 cycles): 1500 IU hCG (IV); G2 (n=215 cycles): 250 μg histrelin acetate (IM).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mares during spring, ovulatory response did not differ between histrelin (90.7%) and hCG (84.1%), P=0.2627.

    In plain wordsIn mares during spring, ovulatory response did not differ between histrelin and hCG.

    Peptide
    Histrelin
    Outcome
    No significant changeSpring ovulatory response
    Study

    horsen: not reported in source

    Mares in a commercial breeding program
    Comparator
    hCG 1500 IU intravenously
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · intramuscularAs given in this study (horse).

    Source sentences

    Summary
    The ovulatory response between G1 and G2 did not differ in spring (84.1% versus 90.7%, P=0.2627) and summer (79.2% versus 85.4%, P=0.3534).
    2 context sentences
    Summary · context
    This study aimed to compare the efficacy of human chorionic gonadotrophin (hCG) and histrelin as ovulation inducers in young, adult, and old mares during spring and summer.
    Summary · context
    Cycles were randomly allotted in two groups; G1 (n=106 cycles): 1500 IU hCG (IV); G2 (n=215 cycles): 250 μg histrelin acetate (IM).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mares during summer, ovulatory response did not differ between histrelin (85.4%) and hCG (79.2%), P=0.3534.

    In plain wordsIn mares during summer, ovulatory response did not differ between histrelin and hCG.

    Peptide
    Histrelin
    Outcome
    No significant changeSummer ovulatory response
    Study

    horsen: not reported in source

    Mares in a commercial breeding program
    Comparator
    hCG 1500 IU intravenously
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · intramuscularAs given in this study (horse).

    Source sentences

    Summary
    The ovulatory response between G1 and G2 did not differ in spring (84.1% versus 90.7%, P=0.2627) and summer (79.2% versus 85.4%, P=0.3534).
    2 context sentences
    Summary · context
    This study aimed to compare the efficacy of human chorionic gonadotrophin (hCG) and histrelin as ovulation inducers in young, adult, and old mares during spring and summer.
    Summary · context
    Cycles were randomly allotted in two groups; G1 (n=106 cycles): 1500 IU hCG (IV); G2 (n=215 cycles): 250 μg histrelin acetate (IM).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In young and adult mares, ovulatory response did not differ between histrelin and hCG, P=0.896.

    In plain wordsIn young and adult mares, ovulatory response did not differ between histrelin and hCG.

    Peptide
    Histrelin
    Outcome
    No significant changeYoung and adult mare ovulatory response
    Study

    horsen: not reported in source

    Mares in a commercial breeding program
    Comparator
    hCG 1500 IU intravenously
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · intramuscularAs given in this study (horse).

    Source sentences

    Summary
    No differences (P=0.896) were found between drugs in young and adult mares.
    2 context sentences
    Summary · context
    This study aimed to compare the efficacy of human chorionic gonadotrophin (hCG) and histrelin as ovulation inducers in young, adult, and old mares during spring and summer.
    Summary · context
    Cycles were randomly allotted in two groups; G1 (n=106 cycles): 1500 IU hCG (IV); G2 (n=215 cycles): 250 μg histrelin acetate (IM).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In old mares during spring and summer, ovulatory response was higher with histrelin than hCG (89.5% versus 45.8%, P<0.0001).

    In plain wordsIn old mares, ovulatory response was higher with histrelin than hCG during spring and summer.

    Peptide
    Histrelin
    Outcome
    IncreaseOld mare ovulatory response
    Study

    horsen: not reported in source

    Mares in a commercial breeding program
    Comparator
    hCG 1500 IU intravenously
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    250 μg · intramuscularAs given in this study (horse).

    Source sentences

    Summary
    However, old mares had a higher percentage of ovulatory response in spring and summer to histrelin (n=76) than to hCG (n=24) (89.5% versus 45.8%, P<0.0001).
    2 context sentences
    Summary · context
    This study aimed to compare the efficacy of human chorionic gonadotrophin (hCG) and histrelin as ovulation inducers in young, adult, and old mares during spring and summer.
    Summary · context
    Cycles were randomly allotted in two groups; G1 (n=106 cycles): 1500 IU hCG (IV); G2 (n=215 cycles): 250 μg histrelin acetate (IM).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

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