Active, not recruitingPhase 4NCT05057546
Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)
University of Colorado, Denvern = 5522 Nov 2021 to est. 28 Jul 2025
Menopause · Estrogen Deficiency · Women · Aging
Degarelix / Studies
Synthetic analog · 10 amino acids · 1,632.3 Da
Degarelix studies and research data
PepBank has 60 degarelix studies with results. All of them gave degarelix, with 329 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.
Searches 329 results and 289 papers. Newer studies from Europe PMC
Results in people
252
77% of 329 results
Results in animals
59
18% of 329 results
Results in lab cells
18
5% of 329 results
From computer models
0
0% of 329 results
The molecule
Degarelix identity
Identifiers, parent molecule, targets and development stage, from curated data.
Degarelix is a synthetic ten-residue GnRH receptor antagonist. It reduces gonadotropin and testosterone release without the initial agonist stimulation.
- Kind
- Synthetic analog · 10 residues
- Identifiers
- ChEMBLCHEMBL415606 (opens in a new tab)PubChem CID16136245 (opens in a new tab)UNIISX0XJI3A11 (opens in a new tab)DrugBankDB06699 (opens in a new tab)CAS214766-78-6
- Parent
- Analog of GonadorelinDegarelix is a synthetic GnRH analog and receptor antagonist. P01148 identifies the human gonadorelin precursor, not degarelix.
- Development
- Approved in the US and EU (Firmagon)An approved medicinal product exists. Availability and other indications can differ. Source (opens in a new tab)
Targets
| Target | Action | Evidence |
|---|---|---|
| Gonadotropin-releasing hormone receptorGNRHRP30968 (opens in a new tab) | Antagonist | Official prescribing information, mechanism of actionSource (opens in a new tab) |
Sequence and structure
Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.
Sequence
10 amino acids · 7 modifications
Residues 1 to 10:
SLP
Alignment to Gonadorelin
Calculated from the two sequences. Curated notes are shown as given.
3 of 10 aligned residues identical (30%) · 7 non-canonical residues · Gonadorelin 1–10
- Top row: Gonadorelin (parent)
- Bottom row: Degarelix
SLP
- Same as parent
- Substituted
- Non-canonical or D-form
- Added
- Gap
- Modified side chain or end
Differences from the parent
- 1Parent 1 · analog 1Xaa → D-2-Nal · Non-canonical residueD-2-Nal
- 2Parent 2 · analog 2His → D-4-Cl-Phe · Non-canonical residueD-4-Cl-Phe
- 3Parent 3 · analog 3Trp → D-3-Pal · Non-canonical residueD-3-Pal
- 4Parent 5 · analog 5Tyr → 4S · Non-canonical residueL-4-Aph bearing an L-dihydroorotyl group with the (4S) ring stereocenter, as specified in the label chemical name.
- 5Parent 6 · analog 6Gly → carbamoyl · Non-canonical residueD-4-Aph(carbamoyl)
- 6Parent 8 · analog 8Arg → Xaa · Non-canonical residueN6-isopropyl-L-lysine
- 7Parent 10 · analog 10Gly → D-Ala · D-amino acidD-Ala
Basis: Degarelix is a synthetic GnRH analog and receptor antagonist. P01148 identifies the human gonadorelin precursor, not degarelix.
Calculated from the two sequences with @pepdb/chem alignToParent (ungapped unless a gap scores higher). The record’s curated notes are shown as given.
Properties
From identity sources
- Formula
- C82H103ClN18O16
- Molecular weight
- 1,632.3 g/mol
- Monoisotopic mass
- 1,630.7488 Da
- GSRS UNII SX0XJI3A11(opens in a new tab)retrieved 2026-10-27
- PubChem CID 16136245(opens in a new tab)retrieved 2026-10-27
- Curated Firmagon US label(opens in a new tab)retrieved 2026-10-27
Calculated from the sequence
Some values cannot be calculated. The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.
- Average mass
- Not calculated
- Monoisotopic mass
- Not calculated
- Isoelectric point (pI)
- Not calculated
- Net charge at pH 7.4
- Not calculated
- GRAVY (hydropathy)
- Not calculated
- Extinction coefficient, 280 nm (Cys reduced)
- 0 M⁻¹ cm⁻¹
- 5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam)
- No Trp or Tyr: absorbance at 280 nm cannot measure this peptide.
- Instability index
- Not calculated
- Aliphatic index
- Not calculated
- Boman index
- Not calculated
- Hydrophobic moment (μH)
- Not calculated
- 6 non-canonical residues (X) are not included in calculated values.
- D-amino acids have the same mass and charge as L forms. Hydrophobicity scales were measured on L forms.
- Defined and validated for proteins; use with care for short peptides.
- Assumes an ideal alpha helix. Many short peptides are not helical.
@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses
Net charge by pH
No charge curve
The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.
Composition
- Hydrophobic20% (2)A L
- Polar10% (1)S
- Special10% (1)P
- Non-canonical60% (6)X
10 residues. Each residue counts in one class; F and W count as aromatic.
A Ala1 · 10%
I Ile0 · 0%
L Leu1 · 10%
M Met0 · 0%
V Val0 · 0%
F Phe0 · 0%
W Trp0 · 0%
Y Tyr0 · 0%
H His0 · 0%
K Lys0 · 0%
R Arg0 · 0%
D Asp0 · 0%
E Glu0 · 0%
N Asn0 · 0%
Q Gln0 · 0%
S Ser1 · 10%
T Thr0 · 0%
C Cys0 · 0%
G Gly0 · 0%
P Pro1 · 10%
X Xaa6 · 60%
3D structure
PredictedAlphaFold DB · P01148
Loads the 3D viewer (3Dmol.js, about 150 KB) and the model file from AlphaFold DB (EMBL-EBI).
2D structure
Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).
SMILES fromPubChem CID 16136245(opens in a new tab)
C[C@H](C(=O)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CC=C(C=C2)NC(=O)N)NC(=O)[C@H](CC3=CC=C(C=C3)NC(=O)[C@@H]4CC(=O)NC(=O)N4)NC(=O)[C@H](CO)NC(=O)[C@@H](CC5=CN=CC=C5)NC(=O)[C@@H](CC6=CC=C(C=C6)Cl)NC(=O)[C@@H](CC7=CC8=CC=CC=C8C=C7)NC(=O)CResults by area
What the studies measured
People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.
Trials and papers
Newer studies
PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.
Status and safety
Data