Effects of testosterone suppression on desire, hypersexuality, and sexual interest in children in men with pedophilic disorder.

In men with pedophilic disorder, degarelix reduced Sexual Desire Inventory scores versus placebo at two weeks (p = 0.001, d = -0.96 [-0.38 to -1.55]).

In plain wordsIn men with pedophilic disorder, degarelix reduced sexual desire scores more than placebo at two weeks.

Measurements

Between-group effect size, Sexual Desire Inventory

−0.96 Cohen's d

Degarelix versus placebo at two weeks; bracketed interval as reported: -0.38 to -1.55

Source sentences

In men with pedophilic disorder, degarelix reduced Sexual Desire Inventory scores versus placebo at ten weeks (p < 0.001, d = -1.30 [-0.69 to -1.91]).

In plain wordsIn men with pedophilic disorder, degarelix reduced sexual desire scores more than placebo at ten weeks.

Measurements

Between-group effect size, Sexual Desire Inventory

−1.3 Cohen's d

Degarelix versus placebo at ten weeks; bracketed interval as reported: -0.69 to -1.91

Source sentences

In men with pedophilic disorder, HBI ratings did not differ significantly between degarelix and placebo at two weeks (p = 0.07, d = -0.52 [0.05 to -1.08]).

In plain wordsIn men with pedophilic disorder, hypersexuality ratings did not differ significantly between degarelix and placebo at two weeks.

Measurements

Between-group effect size, HBI ratings

−0.52 Cohen's d

Degarelix versus placebo at two weeks; bracketed interval as reported: 0.05 to -1.08

Source sentences

In men with pedophilic disorder, degarelix reduced HBI ratings versus placebo at ten weeks (p = 0.01, d = -0.72 [-0.15 to -1.29]).

In plain wordsIn men with pedophilic disorder, degarelix reduced hypersexuality ratings more than placebo at ten weeks.

Measurements

Between-group effect size, HBI ratings

−0.72 Cohen's d

Degarelix versus placebo at ten weeks; bracketed interval as reported: -0.15 to -1.29

Source sentences

In men with pedophilic disorder, 15 of 26 (58%) receiving degarelix versus 3 of 26 (12%) receiving placebo reported no further sexual interest in children at ten weeks (p < 0.0001).

In plain wordsIn men with pedophilic disorder, more participants reported no further sexual interest in children with degarelix than with placebo.

Measurements

Participants reporting no further sexual interest in children

58%

Degarelix group, 15 of 26, at ten weeks

Participants reporting no further sexual interest in children

12%

Placebo group, 3 of 26, at ten weeks

Source sentences

In men with pedophilic disorder, autistic, antisocial, or impulsive traits, age, and attraction onset or duration did not modify degarelix's sexual-interest effect versus placebo.

In plain wordsIn men with pedophilic disorder, traits, age, and attraction history did not modify the degarelix effect versus placebo.

Source sentences