In paedophilic disorder, follow-up analyses found no significant functional connectivity alterations related to degarelix after FDR correction.
In plain wordsIn patients with paedophilic disorder, degarelix showed no significant brain connectivity changes versus placebo after correction for multiple comparisons.
- Peptide
- Degarelix
- Outcome
- No significant changeResting state functional connectivity
- Study
n: not reported in source
- Comparator
- Placebo
- Outcome group
- Receptor activity and mechanism · Nervous system and cognition
- Studied dose
- Dose not stated · injectionAs given in this study (human).
Source sentences
At follow-up time points, however, group comparisons were inconclusive and did after FDR correction not render statistically significant FC alterations when comparing patients to controls or related to degarelix treatment, CSA dynamic risk scores or comorbidities.
1 context sentence(design, population, supporting numbers)
We used independent component analysis on resting state (rs)fMRI data acquired at baseline as well as two and ten weeks after injection of degarelix (or placebo) to evaluate FC alterations related to PeD and the degarelix treatment effect.