Cardiometabolic Consequences of the Loss of Ovarian Function

Short name LILAC

NCTNCT06264882Other id23-1518Other idU54AG062319

Open at ClinicalTrials.govAsk about this trial

Overview

Status: Recruiting
Phase: Phase 4
Enrollment: 100 participants (estimated)
Sponsor: University of Colorado, Denver · Other
Design: Randomized · Triple masking
Countries: 1 country
United States
Start: 1 Jun 2024
Primary completion: 31 May 2028 (estimated)
Completion: 31 Aug 2028 (estimated)
First posted: 20 Feb 2024
Last update posted: 20 Jun 2024
Conditions: Menopause · Estrogen Deficiency · Aging · Adiposity

Timeline

1 trial · 1 ongoing

Completed
Ongoing
Not yet recruiting
Stopped
Estimated dates (est.)
Results posted

202420252026202720282029

Ph 4
LILAC
NCT06264882
1 Jun 2024 to est. 31 Aug 2028

Registry summary

Text and fields below are the sponsor's entries at ClinicalTrials.gov, shown as posted.

The menopause transition is associated with a decrease in artery health and an increased risk for weight gain in storing fat in the stomach area which may increase the risk for heart disease. The purpose of this research is to study how the decrease in estrogen at menopause changes artery health and fat gain, and risk of disease in women as they age. The first aim in this study will determine whether short term and long term low estrogen levels in premenopausal women decreases artery function and whether this is related to an increase in fat in the stomach area. The second aim will determine whether the changes in artery health and body fat are related to changes in a pathway that breaks down an important amino acid called tryptophan. This pathway is thought to play a role in regulating the aging process. Therefore, the investigators will determine whether the decrease in artery health and the increase in body fat in the stomach region with low estrogen is related to changes in this pathway in the blood, in vascular cells and fat tissue. Because estrogen levels fluctuate in premenopausal women, the investigators will use an approach (intervention) that controls estrogen levels to address these aims. The investigators will use a medication that is typically used to treat endometriosis or uterine fibroids to lower estrogen levels and an estrogen patch to increase estrogen in some women. Some women will receive a patch that has no estrogen (called a placebo patch). The intervention period will be 20 weeks. The study will provide us with new knowledge on how low estrogen with menopause affects artery health and fat gain estrogen.

Interventions

DegarelixDrug
Transdermal Estradiol PatchDrug
Transdermal Placebo PatchDrug

Arms2

Experimental
Degarelix plus transdermal placebo
At baseline \& 10 weeks: 80-mg subcutaneous injection of degarelix acetate plus Placebo transdermal patch (applied twice per week)
Experimental
Degarelix plus transdermal estradiol
At baseline \& 10 weeks: 80-mg subcutaneous injection of degarelix acetate plus 0.075mg estradiol transdermal patch (applied twice per week)

Primary outcomes1

Outcomes the sponsor listed as primary.

Brachial artery flow mediated dilation (FMD)
Time frame · Baseline and at 2 and 20 weeks
Registry description
Ultrasound measurements of brachial artery FMD will be performed in the morning under fasted conditions, and analyzed (Vascular Analysis Tools 5.5.1) according to guidelines. Baseline FMD will be assessed during early follicular phase of menstrual cycle. Blood pressure will be measured prior to the FMD. To confirm endothelial-specific effects of the intervention, the investigators will also measure endothelium-independent dilation as brachial artery dilation to sublingual nitroglycerine (0.4 mg). All ultrasound images will be coded by number and blinded to group assignment.

Secondary outcomes(1)

Visceral fat area (VFA)
Time frame · Baseline and at 20 weeks
Registry description
Participants will undergo a CT scan of the abdomen for the assessment of VFA and subcutaneous fat area (SFA). Axial CT images will be obtained through the center of the L2-L3 inter-vertebral disc space at 120 kVp (kilovoltage peak), 200-300 maS, and 10mm slice thickness. Digital images will be analyzed in a blinded manner by the University of Colorado Research Imaging Center (CU-RIC) using Interactive Data language software (ITT Visualization Solutions, Boulder, CO).

Posted results

Values are shown as posted at ClinicalTrials.gov, with their units. PepBank has not converted, pooled or compared them.

No results are posted for this trial.

A trial that is still running, or that stopped early, may post results later.

Registry data comes from ClinicalTrials.gov. Study results come from studies, not from the registry. How PepBank works

Studies0

Studies that cite this trial.

No study cites this trial.

Eligibility

Who could join, as posted.

Sex: Female
Age: from 20 Years up to 45 Years
Healthy volunteers: Accepted

Inclusion and exclusion criteria, as posted

Inclusion Criteria: * Age criteria of 20-45 years: the investigators are determining the effects of ovarian suppression on adiposity and vascular in premenopausal women; * Premenopausal defined as normal menstrual cycle function defined as no more than 1 missed cycle in the previous year: irregular menstrual or missed menstrual cycles could indicate that women are anovulatory and/or perimenopause; * Not pregnant or planning to become pregnant; * Not lactating in the last 3 months; * Serum FSH \<10 IU/L measured during days 1-10 of the menstrual cycle: to ensure the woman is premenopausal and not perimenopausal; * Not on hormonal contraception in the last 3 months; * Sedentary or recreationally active (\<2 days/wk vigorous exercise); * No use of medications that might influence vascular function (i.e., antihypertensives, lipid lowering medications, blood thinners); * No use of antioxidant supplements or chronic NSAIDs or be willing to go off them for 4 weeks prior to enrollment in the study; Exclusion Criteria: * Diabetic or fasted glucose \>126 mg/dL; * Body mass index (BMI) \>35 kg/m2; * Weight change \>5 kg in the last 3 months; * Use of glucocorticoids (inhaled, oral, topical) or drugs that affect glucocorticoid metabolism (e.g., ketoconazole) in the last 3 months; * Excess alcohol consumption, defined as \>14 drinks per week by self-report; * Known hypersensitivity to study medications; * Depressive symptoms, defined as a CES-D score \>16; * Resting blood pressure \>150/90 mmHg; * Preexisting or active cardiac, renal, or hepatic disease: past or current history of these diseases or conditions; * Active or chronic infection: inflammation associated with active or chronic infections impair vascular function; * Thyroid dysfunction, defined as an ultrasensitive TSH \<0.5 or \>5.0 mU/L; volunteers with abnormal TSH values will be reconsidered for participation in the study after follow-up evaluation by the PCP with initiation or adjustment of thyroid hormone replacement; * Smoking or Tobacco use within the previous 12 months; * Severe low bone mass or osteoporosis, defined as a hip or lumbar spine T-score \<-2.0: safety reasons, women who are randomized to the ovarian suppression plus placebo group could see a decrease in bone mineral density due to the suppression of estrogen; * History of venous thromboembolic event (VTE): safety reasons, estradiol therapy can increase the risk of VTE; * History of breast cancer or other estrogen-dependent neoplasm: estradiol therapy is contraindicated;

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