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Study · Animal study (in vivo) · rat · 2022

5 results

Endothelial dysfunction after androgen deprivation therapy and the possible underlying mechanisms.

Teoh JY, Tian XY, Wong CY, Lau CW, Cheng CK, Tang VW, Chan RC, Huang Y, Ng CF

The Prostate27 Sept 2021Cited by 12 (Europe PMC)

PMID34570375 (opens in a new tab)DOI10.1002/pros.24244 (opens in a new tab)PepBankPUB-34570375
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In male rats, degarelix treatment produced aortic endothelial dysfunction, as did the other ADT treatments.

    In plain wordsIn rats, degarelix produced aortic endothelial dysfunction compared with controls.

    Peptide
    Degarelix
    Outcome
    IncreaseAortic endothelial dysfunction
    Study

    ratn: not reported in source

    Male SD rats
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vascular reactivity assays, aorta, intrarenal, and coronary arteries of all three ADT groups showed endothelial dysfunction.
    2 context sentences
    Summary · context
    Twenty-six 12-week-old male SD rats were divided into four groups for different types of ADTs including: the bilateral orchidectomy group (Orx), LHRH agonist group (leuprolide), LHRH antagonist group (degarelix), and control group.
    Summary · context
    After treated with drug or adjuvant injection every 3 weeks for 24 weeks, all rats were sacrificed and total blood were collected.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In male rats, degarelix treatment produced intrarenal endothelial dysfunction, as did the other ADT treatments.

    In plain wordsIn rats, degarelix produced intrarenal endothelial dysfunction compared with controls.

    Peptide
    Degarelix
    Outcome
    IncreaseIntrarenal endothelial dysfunction
    Study

    ratn: not reported in source

    Male SD rats
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vascular reactivity assays, aorta, intrarenal, and coronary arteries of all three ADT groups showed endothelial dysfunction.
    2 context sentences
    Summary · context
    Twenty-six 12-week-old male SD rats were divided into four groups for different types of ADTs including: the bilateral orchidectomy group (Orx), LHRH agonist group (leuprolide), LHRH antagonist group (degarelix), and control group.
    Summary · context
    After treated with drug or adjuvant injection every 3 weeks for 24 weeks, all rats were sacrificed and total blood were collected.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In male rats, degarelix treatment produced coronary endothelial dysfunction, as did the other ADT treatments.

    In plain wordsIn rats, degarelix produced coronary endothelial dysfunction compared with controls.

    Peptide
    Degarelix
    Outcome
    IncreaseCoronary endothelial dysfunction
    Study

    ratn: not reported in source

    Male SD rats
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    In vascular reactivity assays, aorta, intrarenal, and coronary arteries of all three ADT groups showed endothelial dysfunction.
    2 context sentences
    Summary · context
    Twenty-six 12-week-old male SD rats were divided into four groups for different types of ADTs including: the bilateral orchidectomy group (Orx), LHRH agonist group (leuprolide), LHRH antagonist group (degarelix), and control group.
    Summary · context
    After treated with drug or adjuvant injection every 3 weeks for 24 weeks, all rats were sacrificed and total blood were collected.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In male rats, degarelix treatment increased AT1R in kidney tissues.

    In plain wordsIn rats, kidney AT1R increased with degarelix compared with controls.

    Peptide
    Degarelix
    Outcome
    IncreaseKidney AT1R upregulation
    Study

    ratn: not reported in source

    Male SD rats
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    Both ACE and AT1R mRNA levels were doubled in the aorta in the leuprolide group while Orx and degarelix groups showed upregulation of AT1R in the kidney tissues.
    2 context sentences
    Summary · context
    Twenty-six 12-week-old male SD rats were divided into four groups for different types of ADTs including: the bilateral orchidectomy group (Orx), LHRH agonist group (leuprolide), LHRH antagonist group (degarelix), and control group.
    Summary · context
    After treated with drug or adjuvant injection every 3 weeks for 24 weeks, all rats were sacrificed and total blood were collected.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In male rats, degarelix treatment increased AT1R expression in intrarenal arteries.

    In plain wordsIn rats, degarelix increased AT1R expression in intrarenal arteries compared with controls.

    Peptide
    Degarelix
    Outcome
    IncreaseIntrarenal artery AT1R expression
    Study

    ratn: not reported in source

    Male SD rats
    Comparator
    Control group
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    Dose not stated · 24 weeksAs given in this study (rat).

    Source sentences

    Summary
    By immunohistochemistry, our result showed higher expression of AT1R in the intrarenal arteries of leuprolide and degarelix groups.
    2 context sentences
    Summary · context
    Twenty-six 12-week-old male SD rats were divided into four groups for different types of ADTs including: the bilateral orchidectomy group (Orx), LHRH agonist group (leuprolide), LHRH antagonist group (degarelix), and control group.
    Summary · context
    After treated with drug or adjuvant injection every 3 weeks for 24 weeks, all rats were sacrificed and total blood were collected.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 2

    27 Oct 2026, 16:37 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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