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Study · Non-randomized trial · 2020

3 results

T-Cell Infiltration and Adaptive Treg Resistance in Response to Androgen Deprivation With or Without Vaccination in Localized Prostate Cancer.

Obradovic AZ, Dallos MC, Zahurak ML, Partin AW, Schaeffer EM, Ross AE, Allaf ME, Nirschl TR, Liu D, Chapman CG, O'Neal T, Cao H and 7 more

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Durham JN, Guner G, Baena-Del Valle JA, Ertunc O, De Marzo AM, Antonarakis ES, Drake CG

Clinical cancer research : an official journal of the American Association for Cancer Research15 Mar 2020Cited by 109 (Europe PMC)

PMID32173650 (opens in a new tab)PMCIDPMC7334055 (opens in a new tab)DOI10.1158/1078-0432.ccr-19-3372 (opens in a new tab)PepBankPUB-32173650
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanNon-randomized trialMechanism

    In high-risk localized prostate cancer, degarelix alone increased intratumoral CD8-positive T-cell infiltration compared with untreated matched controls.

    In plain wordsIn localized prostate cancer, degarelix alone increased tumor CD8-positive T-cell infiltration compared with untreated matched controls.

    Peptide
    Degarelix
    Outcome
    IncreaseIntratumoral CD8-positive T-cell infiltration
    Study

    n: not reported in source

    Comparator
    Untreated matched controls
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both Cy/GVAX plus degarelix and degarelix alone led to significant increases in intratumoral CD8+ T-cell infiltration and PD-L1 expression as compared with a cohort of untreated, matched controls.
    1 context sentence
    Summary · context
    We conducted a neoadjuvant, randomized study to quantify the immunologic effects of a GM-CSF-secreting allogeneic cellular vaccine in combination with low-dose cyclophosphamide (Cy/GVAX) followed by degarelix versus degarelix alone in patients with high-risk localized prostate adenocarcinoma who wer…
  2. 02HumanNon-randomized trialMechanism

    In high-risk localized prostate cancer, degarelix alone increased PD-L1 expression compared with untreated matched controls.

    In plain wordsIn localized prostate cancer, degarelix alone increased PD-L1 expression compared with untreated matched controls.

    Peptide
    Degarelix
    Outcome
    IncreasePD-L1 expression
    Study

    n: not reported in source

    Comparator
    Untreated matched controls
    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both Cy/GVAX plus degarelix and degarelix alone led to significant increases in intratumoral CD8+ T-cell infiltration and PD-L1 expression as compared with a cohort of untreated, matched controls.
    1 context sentence
    Summary · context
    We conducted a neoadjuvant, randomized study to quantify the immunologic effects of a GM-CSF-secreting allogeneic cellular vaccine in combination with low-dose cyclophosphamide (Cy/GVAX) followed by degarelix versus degarelix alone in patients with high-risk localized prostate adenocarcinoma who wer…
  3. 03HumanNon-randomized trialMechanism

    In high-risk localized prostate cancer, the CD8-positive T-cell infiltrate seen with androgen deprivation by degarelix, with or without Cy/GVAX, was accompanied by a proportional increase in regulatory T cells.

    In plain wordsIn localized prostate cancer, the immune-cell infiltrate seen with degarelix, with or without a vaccine, was accompanied by a proportional increase in regulatory T cells.

    Peptide
    Degarelix
    Outcome
    IncreaseRegulatory T-cell infiltration
    Study

    n: not reported in source

    Outcome group
    Immune response · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, the CD8+ T-cell infiltrate was accompanied by a proportional increase in regulatory T cells (Treg), suggesting that adaptive Treg resistance may dampen the immunogenicity of ADT.
    2 context sentences
    Summary · context
    Both Cy/GVAX plus degarelix and degarelix alone led to significant increases in intratumoral CD8+ T-cell infiltration and PD-L1 expression as compared with a cohort of untreated, matched controls.
    Summary · context
    We conducted a neoadjuvant, randomized study to quantify the immunologic effects of a GM-CSF-secreting allogeneic cellular vaccine in combination with low-dose cyclophosphamide (Cy/GVAX) followed by degarelix versus degarelix alone in patients with high-risk localized prostate adenocarcinoma who wer…

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:34 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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