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Dasiglucagon / Studies
Synthetic analog · 29 amino acids · 3,381.6 Da

Dasiglucagon studies and research data

PepBank has 17 dasiglucagon studies with results. 16 of them gave dasiglucagon, with 97 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 97 results and 24 papers. Newer studies from Europe PMC

Results in people
97
100% of 97 results
Results in animals
0
0% of 97 results
Results in lab cells
0
0% of 97 results
From computer models
0
0% of 97 results
The molecule

Dasiglucagon identity

Identifiers, parent molecule, targets and development stage, from curated data.

Dasiglucagon is a 29-residue glucagon analog for severe hypoglycemia. Its sequence has seven substitutions relative to human glucagon, including Aib16.

Kind
Synthetic analog · 29 residues
Identifiers
ChEMBLCHEMBL4297741 (opens in a new tab)PubChem CID126961379 (opens in a new tab)UNIIAD4J2O47FQ (opens in a new tab)DrugBankDB15226 (opens in a new tab)CAS1544300-84-6
Parent
Analog of Human glucagonGSRS identifies seven substitutions relative to human glucagon: S16Aib, R17A, Q20E, D21E, Q24K, M27E, and N28S. UniProt P01275 identifies the human glucagon precursor.
Development
Approved in the US and EU (Zegalogue, 2021)Zealand Pharma A/SFDA and EMA approved Zegalogue for severe hypoglycemia in patients with diabetes aged 6 years and older. Other indications require separate assessment. Source (opens in a new tab)

Targets

Molecular targets with action and evidence source
TargetActionEvidence
Glucagon receptorGCGRP47871 (opens in a new tab)AgonistOfficial prescribing information, mechanism of actionSource (opens in a new tab)

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

29 amino acids · 1 modification

H-
Residues 1 to 10:
HSQGTFTSDY
Residues 11 to 20:
SKYLDARAE
Residues 21 to 29:
EFVKWLEST
-OH
  • HydrophobicA V I L M
  • AromaticF W Y
  • PositiveK R H
  • NegativeD E
  • PolarS T N Q
  • SpecialC G P
  • Non-canonicalX
  • Modified residue

Modifications

Residue 16
Non-canonical residue
Aib

Alignment to Human glucagon

Calculated from the two sequences. Curated notes are shown as given.

22 of 29 aligned residues identical (76%) · 6 substitutions · 1 non-canonical residue · Human glucagon 1–29

  • Top row: Human glucagon (parent)
  • Bottom row: Dasiglucagon
HSQGTFTSDY
SKYLDRA
FVWLT
  • Same as parent
  • Substituted
  • Non-canonical or D-form
  • Added
  • Gap
  • Modified side chain or end

Differences from the parent

  1. 1Parent 16 · analog 16Ser → Aib · Non-canonical residueAib
  2. 2Parent 17 · analog 17Arg → Ala · Substitution
  3. 3Parent 20 · analog 20Gln → Glu · Substitution
  4. 4Parent 21 · analog 21Asp → Glu · Substitution
  5. 5Parent 24 · analog 24Gln → Lys · Substitution
  6. 6Parent 27 · analog 27Met → Glu · Substitution
  7. 7Parent 28 · analog 28Asn → Ser · Substitution

Basis: GSRS identifies seven substitutions relative to human glucagon: S16Aib, R17A, Q20E, D21E, Q24K, M27E, and N28S. UniProt P01275 identifies the human glucagon precursor.

Calculated from the two sequences with @pepdb/chem alignToParent (ungapped unless a gap scores higher). The record’s curated notes are shown as given.

Properties

From identity sources

Formula
C152H222N38O50
Molecular weight
3,381.6 g/mol
Monoisotopic mass
3,379.5997 Da

Calculated from the sequence

Some values cannot be calculated. The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.

Average mass
Not calculated
Monoisotopic mass
Not calculated
Isoelectric point (pI)
Not calculated
Net charge at pH 7.4
Not calculated
GRAVY (hydropathy)
Not calculated
Extinction coefficient, 280 nm (Cys reduced)
8,480 M⁻¹ cm⁻¹
5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam)
Instability index
Not calculated
Aliphatic index
Not calculated
Boman index
Not calculated
Hydrophobic moment (μH)
Not calculated
  • 1 non-canonical residue (X) is not included in calculated values.
  • Defined and validated for proteins; use with care for short peptides.
  • Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

No charge curve

The sequence has a non-canonical residue (X). Residue tables cover only the 20 standard amino acids.

Composition

  • Hydrophobic17% (5)
  • Aromatic17% (5)
  • Positive14% (4)
  • Negative17% (5)
  • Polar28% (8)
  • Special3% (1)
  • Non-canonical3% (1)

29 residues. Each residue counts in one class; F and W count as aromatic.

A Ala2 · 7%
I Ile0 · 0%
L Leu2 · 7%
M Met0 · 0%
V Val1 · 3%
F Phe2 · 7%
W Trp1 · 3%
Y Tyr2 · 7%
H His1 · 3%
K Lys2 · 7%
R Arg1 · 3%
D Asp2 · 7%
E Glu3 · 10%
N Asn0 · 0%
Q Gln1 · 3%
S Ser4 · 14%
T Thr3 · 10%
C Cys0 · 0%
G Gly1 · 3%
P Pro0 · 0%
X Xaa1 · 3%

3D structure

PredictedAlphaFold DB · P01275

Loads the 3D viewer (3Dmol.js, about 150 KB) and the model file from AlphaFold DB (EMBL-EBI).

  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

Predicted model of the whole UniProt entry P01275, not an experimental structure of Dasiglucagon.

AlphaFold DB, EMBL-EBI and Google DeepMind · CC BY 4.0

2D structure

Dasiglucagon has 29 residues. A full-atom drawing is hard to read at this size; the sequence view is the reference.

SMILES fromPubChem CID 126961379(opens in a new tab)

C[C@H]([C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC3=CC=C(C=C3)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NC(C)(C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC4=CC=CC=C4)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)O)NC(=O)CNC(=O)[C@H](CCC(=O)N)NC(=O)[C@H](CO)NC(=O)[C@H](CC7=CNC=N7)N)O

Helical wheel

An ideal alpha-helix projection. It shows where the hydrophobic residues fall if the peptide folds as a helix. It does not show that it does.

Helical wheel of Dasiglucagon, 29 residues at 100 degrees per residue. Hydrophobic moment 0.05 pointing at 293 degrees.His 1, Eisenberg consensus (normalized) -0.40H1Ser 2, Eisenberg consensus (normalized) -0.18S2Gln 3, Eisenberg consensus (normalized) -0.85Q3Gly 4, Eisenberg consensus (normalized) 0.48G4Thr 5, Eisenberg consensus (normalized) -0.05T5Phe 6, Eisenberg consensus (normalized) 1.19F6Thr 7, Eisenberg consensus (normalized) -0.05T7Ser 8, Eisenberg consensus (normalized) -0.18S8Asp 9, Eisenberg consensus (normalized) -0.90D−9Tyr 10, Eisenberg consensus (normalized) 0.26Y10Ser 11, Eisenberg consensus (normalized) -0.18S11Lys 12, Eisenberg consensus (normalized) -1.50K+12Tyr 13, Eisenberg consensus (normalized) 0.26Y13Leu 14, Eisenberg consensus (normalized) 1.06L14Asp 15, Eisenberg consensus (normalized) -0.90D−15Non-canonical 16X16Ala 17, Eisenberg consensus (normalized) 0.62A17Arg 18, Eisenberg consensus (normalized) -2.53R+18Ala 19, Eisenberg consensus (normalized) 0.62A19Glu 20, Eisenberg consensus (normalized) -0.74E−20Glu 21, Eisenberg consensus (normalized) -0.74E−21Phe 22, Eisenberg consensus (normalized) 1.19F22Val 23, Eisenberg consensus (normalized) 1.08V23Lys 24, Eisenberg consensus (normalized) -1.50K+24Trp 25, Eisenberg consensus (normalized) 0.81W25Leu 26, Eisenberg consensus (normalized) 1.06L26Glu 27, Eisenberg consensus (normalized) -0.74E−27Ser 28, Eisenberg consensus (normalized) -0.18S28Thr 29, Eisenberg consensus (normalized) -0.05T29
μH, residues shown
0.054
μH, best 11-residue window
—
Arrow direction
293°
Residues
29 · 2 rings of 18 · 1 X not scored
HydrophilicHydrophobic

Eisenberg consensus (normalized) scale · + K, R · − D, E

Assumes an ideal α-helix: 100° per residue, 3.6 residues per turn. The arrow is the mean hydrophobic moment (Eisenberg et al. 1984) and points at the hydrophobic face.

Show as table
PositionResidueAngleEisenberg consensus (normalized)
1H0°-0.40
2S100°-0.18
3Q200°-0.85
4G300°0.48
5T40°-0.05
6F140°1.19
7T240°-0.05
8S340°-0.18
9D80°-0.90
10Y180°0.26
11S280°-0.18
12K20°-1.50
13Y120°0.26
14L220°1.06
15D320°-0.90
16X60°not scored
17A160°0.62
18R260°-2.53
19A0°0.62
20E100°-0.74
21E200°-0.74
22F300°1.19
23V40°1.08
24K140°-1.50
25W240°0.81
26L340°1.06
27E80°-0.74
28S180°-0.18
29T280°-0.05
Results by area

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Trials and papers
Status and safety
Data