Modified form · 4 amino acids · 694.9 Da

Palmitoyl tetrapeptide-7 studies and research data

PepBank has 5 palmitoyl tetrapeptide-7 studies with results. 1 of them gave palmitoyl tetrapeptide-7, with 2 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 2 results and 7 papers. Newer studies from Europe PMC

Results in people

0% of 2 results

Results in animals

0% of 2 results

Results in lab cells

100% of 2 results

From computer models

0% of 2 results

The molecule

Palmitoyl tetrapeptide-7 identity

Identifiers, parent molecule, targets and development stage, from curated data.

Palmitoyl tetrapeptide-7 is N-palmitoyl-GQPR. Rigin originally names the unmodified tetrapeptide and is an ambiguous search term. Matrixyl 3000 contains this peptide with palmitoyl tripeptide-1.

Kind: Modified form · 4 residues
Identifiers: PubChem CID10078408 (opens in a new tab)UNIIQ41S464P1R (opens in a new tab)DrugBankDB14137 (opens in a new tab)CAS221227-05-0
Development: UnknownNo formal development phase for this peptide alone was established. NCT05932732 tested a multi-ingredient serum with Hydrafacial devices. Its Phase 4 label does not establish this ingredient phase. Source (opens in a new tab)

Targets

No molecular target is recorded for this peptide.

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

4 amino acids · 1 modification

QPR

Properties

From identity sources

Formula: C₃₄H₆₂N₈O₇
Molecular weight: 694.9 g/mol
Monoisotopic mass: 694.4741 Da

PubChem CID 10078408(opens in a new tab)retrieved 2026-10-27
fda Q41S464P1R(opens in a new tab)retrieved 2026-10-27
ncats Q41S464P1R(opens in a new tab)retrieved 2026-10-27

Calculated from the sequence

pKa set

Some values cannot be calculated. A modification changes this value and is not modeled here (for example a lipid, metal or linker).

Average mass: Not calculated
Monoisotopic mass: Not calculated
Isoelectric point (pI): Not calculated
Net charge at pH 7.4: Not calculated
GRAVY (hydropathy): −2.500; Mean Kyte-Doolittle hydropathy · Kyte and Doolittle 1982; Negative: hydrophilic on average.
Extinction coefficient, 280 nm (Cys reduced): 0 M⁻¹ cm⁻¹; 5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam); No Trp or Tyr: absorbance at 280 nm cannot measure this peptide.
Instability index: 36.80; Dipeptide instability weights (DIWV) · Guruprasad et al. 1990; 40 or below: classed as stable (ExPASy).
Aliphatic index: 0.0; Mole % A + 2.9 V + 3.9 (I + L) · Ikai 1980
Boman index: 4.88 kcal/mol; Mean solubility value (negated) · Boman 2003; Above 2.48: high protein-binding potential (Boman).
Hydrophobic moment (μH): Not calculated; The sequence is too short for this method.

Not included: lipid chain. Mass, charge and pI are not calculated; use the identity-source values.
The N-terminal group is not modeled.
Defined and validated for proteins; use with care for short peptides.
Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

No charge curve

A modification changes this value and is not modeled here (for example a lipid, metal or linker).

Composition

Positive25% (1)R
Polar25% (1)Q
Special50% (2)G P

4 residues. Each residue counts in one class; F and W count as aromatic.

A Ala0 · 0%

I Ile0 · 0%

L Leu0 · 0%

M Met0 · 0%

V Val0 · 0%

F Phe0 · 0%

W Trp0 · 0%

Y Tyr0 · 0%

H His0 · 0%

K Lys0 · 0%

R Arg1 · 25%

D Asp0 · 0%

E Glu0 · 0%

N Asn0 · 0%

Q Gln1 · 25%

S Ser0 · 0%

T Thr0 · 0%

C Cys0 · 0%

G Gly1 · 25%

P Pro1 · 25%

3D structure

No 3D structure

No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.

2D structure

Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).

SMILES fromPubChem CID 10078408(opens in a new tab)

CCCCCCCCCCCCCCCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)O

Results by area

Palmitoyl tetrapeptide-7 results by year and outcome

Counts are exact and come from studies that gave the peptide.

Studies by year

5 of 7 studies have results (71%), published 2015 to 2026. Top row: every study. Bottom row: studies with results about Palmitoyl tetrapeptide-7, by class. The rows use different scales.

Studies
Human
Animal
Lab
Computer model
Natural levels, tool or combination only

Studies7 in all, 2014 to 2026

Studies with results5 in all, 2015 to 2026

Retracted studies are left out. A study with results in two classes counts in both.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Palmitoyl tetrapeptide-7 studies on side effects

1 result · people 0 · animals 0 · lab 1

1 result

In cells, palmitoyl tetrapeptide-7 produced no detectable cytotoxicity after UV exposure.International journal of cosmetic science, 2026

Palmitoyl tetrapeptide-7 studies on skin, hair and wounds

1 result · people 0 · animals 0 · lab 1

1 result

In cells, palmitoyl tetrapeptide-7 significantly increased type III collagen levels after UV exposure.International journal of cosmetic science, 2026

Trials and papers

Palmitoyl tetrapeptide-7 trials

Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.

StatusPhase

0 trials match. Highest phase first. Data from ClinicalTrials.gov.

No trial matches these filters.

1 more mentions it but does not test it. They are not trials of Palmitoyl tetrapeptide-7: they only measure it (a blood level or an eligibility term) or name it in their text.

Papers

Studies on this peptide. Some have results. The others have none yet.

Sort

Design

7 studies match. Retracted studies are left out.

Showing 6 of 7 studiesquery qry_8af3df1ff2d5c7c2e6365f2a

Studies with results

5 studies

Not a test of Palmitoyl tetrapeptide-7 alone · 2015

3 results

Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.

Mondon et al. 2015Journal of cosmetic dermatologycited by 17

PMID 25817264DOI 10.1111/jocd.12135PUB-25817264

Full text at the publisher3 results where Palmitoyl tetrapeptide-7 was a tool, carrier or part of a combination

Publisher page See results (3)

Not a test of Palmitoyl tetrapeptide-7 alone · 2024

10 results

Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.

Yang et al. 2024Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)cited by 5

PMID 38932444PMC11208285DOI 10.1111/srt.13790PUB-38932444

Free to read · publisher termsCC BY-NC-ND10 results where Palmitoyl tetrapeptide-7 was a tool, carrier or part of a combination

Read at source See results (10)

Not a test of Palmitoyl tetrapeptide-7 alone · 2025

13 results

Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing.

Xing et al. 2025International journal of biological macromoleculescited by 5

PMID 40023432DOI 10.1016/j.ijbiomac.2025.141578PUB-40023432

Full text at the publisher13 results where Palmitoyl tetrapeptide-7 was a tool, carrier or part of a combination

Publisher page See results (13)

In vitro (cells) · 2026

18 results

Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.

Zang et al. 2026International journal of cosmetic science

PMID 42683869DOI 10.1111/ics.70140PUB-42683869

Full text at the publisher2 results where Palmitoyl tetrapeptide-7 was given (plus 4 on tools or combinations, listed separately)

Publisher page See results (18)

Not a test of Palmitoyl tetrapeptide-7 alone · 2026

6 results

Permeation behaviour of cosmetic actives into the human stratum corneum.

Trzaska et al. 2026International journal of pharmaceutics

PMID 42790608DOI 10.1016/j.ijpharm.2026.127447PUB-42790608

Full text at the publisher3 results where Palmitoyl tetrapeptide-7 was a tool, carrier or part of a combination

Publisher page See results (6)

More studies

1 study

PubMed tag: review-article, Review · 2021

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

DISP et al. 2021Pharmaceuticals (Basel, Switzerland)cited by 25

PMID 34451799PMC8400021DOI 10.3390/ph14080702PUB-34451799

CC BY

Download PDF

No result for Palmitoyl tetrapeptide-7 (1 study on this page)

These studies name Palmitoyl tetrapeptide-7 but give no result for it (for example, the results concern another peptide in the study).

Indexing hint: Animal study · 2014

Quantitative analysis of ligand effects on bioefficacy of nanoemulsion encapsulating depigmenting active.

Atrux-Tallau et al. 2014Colloids and surfaces. B, Biointerfacescited by 14

PMID 25087020DOI 10.1016/j.colsurfb.2014.07.021PUB-25087020

Full text at the publisher

Publisher page

Newer studies

PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.

Palmitoyl tetrapeptide-7 studies: 5 papers with results

Page 1 of 1

Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.
Zang S · International journal of cosmetic science · 2026
In vitro (cells) · 18 results
Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing.
Xing C · International journal of biological macromolecules · 2025
Not a test of Palmitoyl tetrapeptide-7 alone · 13 results
Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.
Yang F · Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
Not a test of Palmitoyl tetrapeptide-7 alone · 10 results
Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.
Mondon P · Journal of cosmetic dermatology · 2015
Not a test of Palmitoyl tetrapeptide-7 alone · 3 results
Permeation behaviour of cosmetic actives into the human stratum corneum.
Trzaska AH · International journal of pharmaceutics · 2026
Not a test of Palmitoyl tetrapeptide-7 alone · 6 results

Status and safety

Regulatory and safety

Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.

Regulatory status by jurisdiction, with date and source
Jurisdiction	Body	Status	As of	Source
US	FDA	FDA identifies this cosmetic peptide and its UNII. A UNII does not establish approval. NCATS lists inactive-ingredient occurrences, not approval of this peptide as an active medicine.	27 Oct 2026	precision.fda.gov (opens in a new tab)
EU	EMA	No medicinal marketing authorisation was established in this review. An ingredient listing or EMA substance identifier does not establish medicinal approval.	27 Oct 2026	m.jchem.ci.gsrs.ncats.io (opens in a new tab)
Sport	WADA	Status unknown Neither palmitoyl tetrapeptide-7 nor Rigin appears by name in the 2026 list.	2026 List	wada-ama.org (opens in a new tab)
European Union	Note	SpecialChem reports INCI PALMITOYL TETRAPEPTIDE-7 and CosIng reference 56918. The official detail page timed out. This secondary report does not establish medicinal approval.	27 Oct 2026	specialchem.com (opens in a new tab)

Safety outcomes

1 safety result for Palmitoyl tetrapeptide-7.

No safety results from studies in people

The safety results below come from animal or lab studies. They do not show what happens in people.

Lab evidence· 1

In human dermal fibroblasts, palmitoyl tetrapeptide-7 produced no detectable cytotoxicity following UV exposure.
In vitro (cells)human

Doses studied

The doses that these studies used. They are not recommendations.

No dose was reported in the study results.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Data

Data and API

Data version, change history and code for this peptide.

Data version 30856030 Oct 2026

Peptide

Peptide id: PEP-000154
Peptide version: 2
Peptide hash: d4358d72a4e1e9e2…
Data version: 308560

Latest changes

27 Oct 2026UpdatedData version 287302
27 Oct 2026CreatedData version 256747

For developers

curl -s https://pepbank.io/v1/briefs/palmitoyl-tetrapeptide-7

Evidence summary for Palmitoyl tetrapeptide-7: counts by class, key results with sources, notices, data version.

Peptide as JSON Evidence summary as JSON

Outcome group	Human	Animal	Lab	Computer model	Total
Adverse eventsSkin and wound	No results	No results	Lab: 1 result from 1 study: 1 not reported. Strongest design: In vitro (cells)	No results	1
Skin and hairSkin and wound	No results	No results	Lab: 1 result from 1 study: 1 increase. Strongest design: In vitro (cells)	No results	1

Outcome group	Human	Animal	Lab	Computer model	Total
Adverse eventsSkin and wound	No results	No results	Lab: 1 result from 1 study: 1 not reported. Strongest design: In vitro (cells)	No results	1
Skin and hairSkin and wound	No results	No results	Lab: 1 result from 1 study: 1 increase. Strongest design: In vitro (cells)	No results	1

Palmitoyl tetrapeptide-7 studies and research data

Palmitoyl tetrapeptide-7 identity

Targets

Sequence and structure

Sequence

Properties

Net charge by pH

Composition

3D structure

2D structure

Palmitoyl tetrapeptide-7 results by year and outcome

What the studies measured

Palmitoyl tetrapeptide-7 studies on side effects

Palmitoyl tetrapeptide-7 studies on skin, hair and wounds

Palmitoyl tetrapeptide-7 trials

Papers

Studies with results

Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.

Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.

Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing.

Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.

Permeation behaviour of cosmetic actives into the human stratum corneum.

More studies

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

Quantitative analysis of ligand effects on bioefficacy of nanoemulsion encapsulating depigmenting active.

Newer studies

Palmitoyl tetrapeptide-7 studies: 5 papers with results

Regulatory and safety

Lab evidence· 1

Doses studied

Data and API

Peptide

Latest changes

For developers

Related peptides

Palmitoyl tetrapeptide-7 results by year and outcome

Palmitoyl tetrapeptide-7 studies on side effects

Palmitoyl tetrapeptide-7 studies on skin, hair and wounds

Palmitoyl tetrapeptide-7 trials

Papers

Studies with results

Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications.

Comprehensive evaluation of the efficacy and safety of a new multi-component anti-aging topical eye cream.

Injectable polypeptide/chitosan hydrogel with loaded stem cells and rapid gelation promoting angiogenesis for diabetic wound healing.

Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.

Permeation behaviour of cosmetic actives into the human stratum corneum.

More studies

Usage of Synthetic Peptides in Cosmetics for Sensitive Skin.

Quantitative analysis of ligand effects on bioefficacy of nanoemulsion encapsulating depigmenting active.

Palmitoyl tetrapeptide-7 studies: 5 papers with results

Regulatory and safety

Lab evidence· 1

Doses studied

Data and API

Peptide

Latest changes

For developers