Skip to content

Study · Not a test of the peptide alone · 2026

6 results

Permeation behaviour of cosmetic actives into the human stratum corneum.

Trzaska AH, Kotowska AM, Starr NJ, Humphreys AJ, Sabri AB, O'Mahony MM, Bell M, Griffiths RL, Alexander MR, Scurr DJ

International journal of pharmaceutics25 Sept 2026

PMID42790608 (opens in a new tab)DOI10.1016/j.ijpharm.2026.127447 (opens in a new tab)PepBankPUB-42790608
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

  1. 01HumanNot a test of Palmitoyl tripeptide-1 aloneNon-randomized trialPharmacokinetics

    In volunteers, Pal-GHK in a multi-active serum was detected throughout the stratum corneum, with decreasing ion intensity at greater depth.

    In plain wordsIn volunteers, Pal-GHK in a multi-active serum reached all sampled stratum corneum layers, with lower signals at greater depth.

    Peptide
    Palmitoyl tripeptide-1
    Outcome
    DecreaseStratum corneum distribution
    Study

    n = 3

    Outcome group
    Pharmacokinetics · Skin and wound

    Source sentences

    Summary
    OrbiSIMS analysis of Pal-GHK and Pal-GQPR detected both peptides throughout every layer of the stratum corneum, demonstrating decreasing ion intensities with depth and no significant changes relative to exposure time.
    2 context sentences
    Summary · context
    Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Orbital trapping SIMS (OrbiSIMS) were used to investigate the in vivo permeation behaviour of these cosmetic actives through the stratum corneum of three healthy female volunteers following topical application of cosmetic serum formulations.
    Summary · context
    Serum formulations containing 3-O-ethyl ascorbic acid and Matrixyl™ 3000 were applied for exposure times of 0.5, 2, and 5 h, while a serum containing ascorbyl glucoside was applied for 0.5 h.

    In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.

  2. 02HumanNot a test of Palmitoyl tetrapeptide-7 aloneNon-randomized trialPharmacokinetics

    In volunteers, Pal-GQPR in a multi-active serum was detected throughout the stratum corneum, with decreasing ion intensity at greater depth.

    In plain wordsIn volunteers, Pal-GQPR in a multi-active serum reached all sampled stratum corneum layers, with lower signals at greater depth.

    Peptide
    Palmitoyl tetrapeptide-7
    Outcome
    DecreaseStratum corneum distribution
    Study

    n = 3

    Outcome group
    Pharmacokinetics · Skin and wound

    Source sentences

    Summary
    OrbiSIMS analysis of Pal-GHK and Pal-GQPR detected both peptides throughout every layer of the stratum corneum, demonstrating decreasing ion intensities with depth and no significant changes relative to exposure time.
    2 context sentences
    Summary · context
    Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Orbital trapping SIMS (OrbiSIMS) were used to investigate the in vivo permeation behaviour of these cosmetic actives through the stratum corneum of three healthy female volunteers following topical application of cosmetic serum formulations.
    Summary · context
    Serum formulations containing 3-O-ethyl ascorbic acid and Matrixyl™ 3000 were applied for exposure times of 0.5, 2, and 5 h, while a serum containing ascorbyl glucoside was applied for 0.5 h.

    In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.

  3. 03HumanNot a test of Palmitoyl tripeptide-1 aloneNon-randomized trialPharmacokinetics

    In volunteers, Pal-GHK ion intensity after multi-active serum application did not change significantly with exposure time.

    In plain wordsIn volunteers, Pal-GHK signals in the stratum corneum after multi-active serum application did not change significantly with exposure time.

    Peptide
    Palmitoyl tripeptide-1
    Outcome
    No significant changeExposure-time dependence of skin signal
    Study

    n = 3

    Outcome group
    Pharmacokinetics · Skin and wound

    Source sentences

    Summary
    OrbiSIMS analysis of Pal-GHK and Pal-GQPR detected both peptides throughout every layer of the stratum corneum, demonstrating decreasing ion intensities with depth and no significant changes relative to exposure time.
    2 context sentences
    Summary · context
    Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Orbital trapping SIMS (OrbiSIMS) were used to investigate the in vivo permeation behaviour of these cosmetic actives through the stratum corneum of three healthy female volunteers following topical application of cosmetic serum formulations.
    Summary · context
    Serum formulations containing 3-O-ethyl ascorbic acid and Matrixyl™ 3000 were applied for exposure times of 0.5, 2, and 5 h, while a serum containing ascorbyl glucoside was applied for 0.5 h.

    In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.

  4. 04HumanNot a test of Palmitoyl tetrapeptide-7 aloneNon-randomized trialPharmacokinetics

    In volunteers, Pal-GQPR ion intensity after multi-active serum application did not change significantly with exposure time.

    In plain wordsIn volunteers, Pal-GQPR signals in the stratum corneum after multi-active serum application did not change significantly with exposure time.

    Peptide
    Palmitoyl tetrapeptide-7
    Outcome
    No significant changeExposure-time dependence of skin signal
    Study

    n = 3

    Outcome group
    Pharmacokinetics · Skin and wound

    Source sentences

    Summary
    OrbiSIMS analysis of Pal-GHK and Pal-GQPR detected both peptides throughout every layer of the stratum corneum, demonstrating decreasing ion intensities with depth and no significant changes relative to exposure time.
    2 context sentences
    Summary · context
    Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Orbital trapping SIMS (OrbiSIMS) were used to investigate the in vivo permeation behaviour of these cosmetic actives through the stratum corneum of three healthy female volunteers following topical application of cosmetic serum formulations.
    Summary · context
    Serum formulations containing 3-O-ethyl ascorbic acid and Matrixyl™ 3000 were applied for exposure times of 0.5, 2, and 5 h, while a serum containing ascorbyl glucoside was applied for 0.5 h.

    In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.

  5. 05HumanNot a test of Palmitoyl tripeptide-1 aloneNon-randomized trialPharmacokinetics

    In volunteers, Pal-GHK profiles after multi-active serum application suggested localization on outer stratum corneum cell surfaces rather than inside cells.

    In plain wordsIn volunteers, Pal-GHK profiles after multi-active serum application suggested localization outside stratum corneum cells.

    Peptide
    Palmitoyl tripeptide-1
    Outcome
    Not applicableIntercellular localization
    Study

    n = 3

    Outcome group
    Pharmacokinetics · Skin and wound

    Source sentences

    Summary
    The OrbiSIMS depth profiling demonstrated that the ion intensities for both peptides dropped immediately, suggesting that they were only present on the outer surfaces of the cells and not within them (intercellular).
    2 context sentences
    Summary · context
    Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Orbital trapping SIMS (OrbiSIMS) were used to investigate the in vivo permeation behaviour of these cosmetic actives through the stratum corneum of three healthy female volunteers following topical application of cosmetic serum formulations.
    Summary · context
    Serum formulations containing 3-O-ethyl ascorbic acid and Matrixyl™ 3000 were applied for exposure times of 0.5, 2, and 5 h, while a serum containing ascorbyl glucoside was applied for 0.5 h.

    In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.

  6. 06HumanNot a test of Palmitoyl tetrapeptide-7 aloneNon-randomized trialPharmacokinetics

    In volunteers, Pal-GQPR profiles after multi-active serum application suggested localization on outer stratum corneum cell surfaces rather than inside cells.

    In plain wordsIn volunteers, Pal-GQPR profiles after multi-active serum application suggested localization outside stratum corneum cells.

    Peptide
    Palmitoyl tetrapeptide-7
    Outcome
    Not applicableIntercellular localization
    Study

    n = 3

    Outcome group
    Pharmacokinetics · Skin and wound

    Source sentences

    Summary
    The OrbiSIMS depth profiling demonstrated that the ion intensities for both peptides dropped immediately, suggesting that they were only present on the outer surfaces of the cells and not within them (intercellular).
    2 context sentences
    Summary · context
    Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) and Orbital trapping SIMS (OrbiSIMS) were used to investigate the in vivo permeation behaviour of these cosmetic actives through the stratum corneum of three healthy female volunteers following topical application of cosmetic serum formulations.
    Summary · context
    Serum formulations containing 3-O-ethyl ascorbic acid and Matrixyl™ 3000 were applied for exposure times of 0.5, 2, and 5 h, while a serum containing ascorbyl glucoside was applied for 0.5 h.

    In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 4Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Versions 2 to 3

    27 Oct 2026, 16:32 UTC

    The same notice was added 2 times, first on 27 Oct 2026, 16:32 UTC. The status did not change between them.

    Study data updated · source update from Europe PMC

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.