Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking.

Zang S, Chen Z, Qiu J, Gu Y, Li N, Zhang L, Wang W, Chen X, Ma Y, Pan A, Lan W, Yu L, Wang M, Wang S

International journal of cosmetic science2 Sept 2026

PMID42683869DOI10.1111/ics.70140PepBankPUB-42683869

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study18

6 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In UV-exposed human dermal fibroblasts, acetyl hexapeptide‑8 significantly increased type III collagen levels.
In plain wordsIn cells exposed to UV, acetyl hexapeptide‑8 increased type III collagen levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseType III collagen
Study
humann: not reported in source
UV-exposed human dermal fibroblasts
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
Report a problemFND-4268386901
02LabIn vitro (cells)Safety outcome
In human dermal fibroblasts, acetyl hexapeptide‑8 showed no detectable cytotoxicity.
In plain wordsIn cells, acetyl hexapeptide‑8 showed no detectable toxicity.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
No significant changeCytotoxicity
Study
humann: not reported in source
UV-exposed human dermal fibroblasts
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
Report a problemFND-4268386902
03LabIn vitro (cells)Efficacy outcome
In human dermal fibroblasts, palmitoyl tetrapeptide-7 significantly increased type III collagen levels following UV exposure.
In plain wordsIn cells, palmitoyl tetrapeptide-7 significantly increased type III collagen levels after UV exposure.
Peptide
Palmitoyl tetrapeptide-7
Outcome
IncreaseType III collagen levels after UV exposure
Study
humann: not reported in source
Human dermal fibroblasts
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
Report a problemFND-4268386907
04LabIn vitro (cells)Safety outcome
In human dermal fibroblasts, palmitoyl tetrapeptide-7 produced no detectable cytotoxicity following UV exposure.
In plain wordsIn cells, palmitoyl tetrapeptide-7 produced no detectable cytotoxicity after UV exposure.
Peptide
Palmitoyl tetrapeptide-7
Outcome
Direction not reportedDetectable cytotoxicity
Study
humann: not reported in source
Human dermal fibroblasts
Outcome group
Adverse events · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
Report a problemFND-4268386908
05LabIn vitro (cells)Efficacy outcome
In human dermal fibroblasts, palmitoyl tripeptide-1 significantly increased type III collagen levels following UV exposure.
In plain wordsIn cells, palmitoyl tripeptide-1 significantly increased type III collagen levels after UV exposure.
Peptide
Palmitoyl tripeptide-1
Outcome
IncreaseType III collagen levels following UV exposure
Study
humann: not reported in source
Human dermal fibroblasts following UV exposure
Outcome group
Skin and hair · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
Report a problemFND-4268386913
06LabIn vitro (cells)Safety outcome
In human dermal fibroblasts, palmitoyl tripeptide-1 produced no detectable cytotoxicity following UV exposure.
In plain wordsIn cells, palmitoyl tripeptide-1 caused no detectable cell toxicity after UV exposure.
Peptide
Palmitoyl tripeptide-1
Outcome
No significant changeDetectable cytotoxicity
Study
humann: not reported in source
Human dermal fibroblasts following UV exposure
Outcome group
Adverse events · Skin and wound
Studied dose
Dose not stated
Source sentences
Summary
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
1 context sentence(design, population, supporting numbers)
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
Report a problemFND-4268386914

Studies that did not test the peptide alone12

In this study, the peptide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking the peptide.

07LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement
In ex vivo skin, the four-peptide combination including acetyl hexapeptide‑8 enhanced type I collagen levels.
In plain wordsIn lab tests with skin, the four-peptide combination increased type I collagen levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseType I collagen with peptide combination
Study
n: not reported in source
ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4268386904
08LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement
In ex vivo skin, the four-peptide combination including acetyl hexapeptide‑8 enhanced type III collagen levels.
In plain wordsIn lab tests with skin, the four-peptide combination increased type III collagen levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseType III collagen with peptide combination
Study
n: not reported in source
ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4268386905
09LabNot a test of Argireline (acetyl hexapeptide-8) aloneEx vivo tissueActivity measurement
In ex vivo skin, the four-peptide combination including acetyl hexapeptide‑8 enhanced type IV collagen levels.
In plain wordsIn lab tests with skin, the four-peptide combination increased type IV collagen levels.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseType IV collagen with peptide combination
Study
n: not reported in source
ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4268386906
10LabNot a test of Palmitoyl tetrapeptide-7 aloneEx vivo tissueEfficacy outcome
In ex vivo skin tissues, the four-peptide combination enhanced type I collagen levels.
In plain wordsIn lab tests with skin tissues, the four-peptide combination increased type I collagen levels.
Peptide
Palmitoyl tetrapeptide-7
Outcome
IncreaseType I collagen levels
Study
n: not reported in source
Ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.
Report a problemFND-4268386910
11LabNot a test of Palmitoyl tetrapeptide-7 aloneEx vivo tissueEfficacy outcome
In ex vivo skin tissues, the four-peptide combination enhanced type III collagen levels.
In plain wordsIn lab tests with skin tissues, the four-peptide combination increased type III collagen levels.
Peptide
Palmitoyl tetrapeptide-7
Outcome
IncreaseType III collagen levels
Study
n: not reported in source
Ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.
Report a problemFND-4268386911
12LabNot a test of Palmitoyl tetrapeptide-7 aloneEx vivo tissueEfficacy outcome
In ex vivo skin tissues, the four-peptide combination enhanced type IV collagen levels.
In plain wordsIn lab tests with skin tissues, the four-peptide combination increased type IV collagen levels.
Peptide
Palmitoyl tetrapeptide-7
Outcome
IncreaseType IV collagen levels
Study
n: not reported in source
Ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.
Report a problemFND-4268386912
13LabNot a test of Palmitoyl tripeptide-1 aloneEx vivo tissueEfficacy outcome
In ex vivo skin tissues, the peptide combination containing palmitoyl tripeptide-1 enhanced type I collagen levels.
In plain wordsIn lab tests on skin tissue, the combination containing palmitoyl tripeptide-1 increased type I collagen levels.
Peptide
Palmitoyl tripeptide-1
Outcome
IncreaseType I collagen levels
Study
n: not reported in source
Ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.
Report a problemFND-4268386916
14LabNot a test of Palmitoyl tripeptide-1 aloneEx vivo tissueEfficacy outcome
In ex vivo skin tissues, the peptide combination containing palmitoyl tripeptide-1 enhanced type III collagen levels.
In plain wordsIn lab tests on skin tissue, the combination containing palmitoyl tripeptide-1 increased type III collagen levels.
Peptide
Palmitoyl tripeptide-1
Outcome
IncreaseType III collagen levels
Study
n: not reported in source
Ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.
Report a problemFND-4268386917
15LabNot a test of Palmitoyl tripeptide-1 aloneEx vivo tissueEfficacy outcome
In ex vivo skin tissues, the peptide combination containing palmitoyl tripeptide-1 enhanced type IV collagen levels.
In plain wordsIn lab tests on skin tissue, the combination containing palmitoyl tripeptide-1 increased type IV collagen levels.
Peptide
Palmitoyl tripeptide-1
Outcome
IncreaseType IV collagen levels
Study
n: not reported in source
Ex vivo skin tissues
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
In ex vivo skin tissues, the peptide combination further enhanced the levels of type I, III and IV collagens, indicating a broader modulatory effect on dermal ECM components.
1 context sentence(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.
Report a problemFND-4268386918
16LabNot a test of Argireline (acetyl hexapeptide-8) aloneIn vitro (cells)Activity measurement
In fibroblasts, the combination of four peptides including acetyl hexapeptide‑8 increased type III collagen more than individual components.
In plain wordsIn cells, the four-peptide combination increased type III collagen more than individual peptides.
Peptide
Argireline (acetyl hexapeptide-8)
Outcome
IncreaseType III collagen with peptide combination
Study
humann: not reported in source
UV-exposed human dermal fibroblasts
Comparator
Individual peptide components
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The combination of these peptides exhibited a greater effect than individual components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Argireline (acetyl hexapeptide-8) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Argireline (acetyl hexapeptide-8).
Report a problemFND-4268386903
17LabNot a test of Palmitoyl tetrapeptide-7 aloneIn vitro (cells)Efficacy outcome
In human dermal fibroblasts, the four-peptide combination increased type III collagen levels more than individual components.
In plain wordsIn cells, the four-peptide combination increased type III collagen levels more than individual components.
Peptide
Palmitoyl tetrapeptide-7
Outcome
IncreaseType III collagen levels
Study
humann: not reported in source
Human dermal fibroblasts
Comparator
Individual peptide components
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The combination of these peptides exhibited a greater effect than individual components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Palmitoyl tetrapeptide-7 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tetrapeptide-7.
Report a problemFND-4268386909
18LabNot a test of Palmitoyl tripeptide-1 aloneIn vitro (cells)Efficacy outcome
In human dermal fibroblasts, the four-peptide combination containing palmitoyl tripeptide-1 increased type III collagen more than individual components.
In plain wordsIn cells, the combination containing palmitoyl tripeptide-1 increased type III collagen more than individual peptides.
Peptide
Palmitoyl tripeptide-1
Outcome
IncreaseType III collagen levels with peptide combination
Study
humann: not reported in source
Human dermal fibroblasts
Comparator
Individual peptide components
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
The combination of these peptides exhibited a greater effect than individual components.
2 context sentences(design, population, supporting numbers)
Summary · context
In vitro, four selected peptides-palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1 and palmitoyl tetrapeptide-10-significantly increased type III collagen levels following UV exposure, without detectable cytotoxicity.
Summary · context
Candidate peptides were selected for experimental evaluation using human dermal fibroblasts and ex vivo skin models.
In this study, Palmitoyl tripeptide-1 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-1.
Report a problemFND-4268386915

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Versions 3 to 4Current
27 Oct 2026, 16:32 UTC
The same notice was added 2 times, first on 27 Oct 2026, 16:32 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 2
22 Oct 2026, 02:25 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

Keywords

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