Peptides / Longevity and mitochondria

Synthetic analog · 4 amino acids · 489.5 Da

Cardiogen (AEDR)

Not approvedBanned in sport

Cardiogen is a short synthetic peptide (Ala-Glu-Asp-Arg) from the Khavinson bioregulator family, not approved and banned in sport as an unapproved substance. Its few studies are in animals and lab cells, on tumor growth and the heart. PepBank shows 13 results on Cardiogen from animal and lab studies. No study in people has reported results yet. Data as of 2026-10-30.

Also known as AEDR, Ala-Glu-Asp-Arg, Cardiogen, Cardiogen peptide

4 amino acids, from first to lastAEDR

Evidence level: Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Results in people

0% of 13 results

Results in animals

38% of 13 results

Results in lab cells

62% of 13 results

From computer models

0% of 13 results

Overview

Cardiogen (AEDR) at a glance

What it is	Synthetic analog, 4 amino acids
Approval	Not approved for any use
In sport	Banned in sport (WADA S0)
Studies	4 studies with results. 3 of them gave Cardiogen, with 13 results. 5 in animals8 in lab cells
Clinical trials	None registered
Community use	Community cardiac aging use

The science

What is Cardiogen?

Synthetic Ala-Glu-Asp-Arg tetrapeptide from the Khavinson bioregulator family.

Amino acids in one chain

Cardiogen (AEDR) structure and chemistry

The key facts about the molecule. Long codes are in the closed section below.

Sequence, 4 amino acidsFrom the first amino acid to the last

A1−E−D+R

Darker means more water-repelling+ and − show charge in the body

Structure

Cardiogen (AEDR) is a synthetic analog of 4 amino acids, with no ring, no changed amino acids.

Formula

C₁₈H₃₁N₇O₉

Molecular weight

489.5 g/mol

CAS number

857267-11-9

Development

Highest phase: no known clinical development.

Identifiers

PubChem 11583989

Full sequence, SMILES and InChIKey

Three-letter sequence
H-Ala-Glu-Asp-Arg-OH

InChIKey
QXQARLZWUIQZPX-NAKRPEOUSA-N

SMILES
C[C@@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)O)N

See charge, composition and 3D structure on the Scientific page

The evidence

What Cardiogen studies show

Results grouped by what the studies measured. Each card shows where its results come from.

Animal and lab studies onlyNo study in people has results. ClinicalTrials.gov lists no trial.

Cancer

3 results · 3 animal

In rats with tumors, Cardiogen increased tumor cell death compared with control. Bulletin of experimental biology and medicine, 2009

Heart and blood vessels

2 results · 2 lab

In lab tests with heart tissue from young rats, cardiogen increased cell proliferation. Advances in gerontology = Uspekhi gerontologii, 2009

Key Cardiogen studies

Studies in people come first, then studies in animals and in the lab.

Animals
Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats
Levdik et al. 2009 · Bulletin of experimental biology and medicine · cited by 0
5 results
Lab cells
[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats]
Chalisova et al. 2009 · Advances in gerontology = Uspekhi gerontologii · cited by 0
3 results
Lab cells
Tetrapeptide H-Ala-Glu-Asp-Arg-OH stimulates expression of cytoskeletal and nuclear matrix proteins
Khavinson et al. 2012 · Bulletin of experimental biology and medicine · cited by 1
5 results

All 4 Cardiogen (AEDR) studies

Cardiogen clinical trials

ClinicalTrials.gov lists no trial of Cardiogen. A trial under another name may exist.

Status and safety

Is Cardiogen approved?

FDA

United States

Not approved

No approved medicine contains it.

EMA

European Union

Not approved

No approved medicine contains it.

WADA

Sport

Banned

On the 2026 Prohibited List, section S0.

No. Not approved for any use. The sources we use show no clinical development. They show no approval at the FDA, the EMA or elsewhere (as of 13 Oct 2026). Banned in sport (WADA S0).

Laws and labels change, so check the regulator for the current status.

Cardiogen side effects and safety

PepBank has no safety result from studies of Cardiogen yet. That does not mean Cardiogen is safe.

Doses studied (1 shown)

The doses that these studies used. They are not recommendations.

Dose as reported	Class	Species	Route	Duration	Design	Source
10(-12) M	Lab	rat	Not reported	Not reported	Study on tissue taken from a body	Chalisova 2009

From the community

How people use it

What people report online. It comes from forums and guides, not from studies.

Community-reported. Not tested in trials.

The source reports this use pattern. It does not establish safety or efficacy.

Reported routines and cautions

What people use it for

Community cardiac aging useS1

Reported regimens

Regimens that community sources report for Cardiogen. Community-reported, not tested in trials.
Context	Route	Amount	How often	How long	Agreement	Sources
Community cardiac aging use	subcutaneous injection	1 mg per dose	once daily	10 to 20 days	single source	S1

Community sources

S1Cardiogen community guide (opens in a new tab)vialguide.com

Gaps

Single-source report. Product identity, actual use and product purity were not independently tested.

Questions and more

Ask a question about Cardiogen

The answer links to every study it uses.

What does the evidence say about Cardiogen?Is Cardiogen tested in people?Compare with Elamipretide (SS-31)Compare with AICAR (acadesine)

Sources

Database: PepBank data for Cardiogen (data version 308560)
Regulator: FDA status record
Regulator: EMA status record
Regulator: WADA status record
Community: community sources (forums and guides), as summarized in the PepBank community file

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Ask your AI about Cardiogen

Curo is a peptide shop. PepBank and Curo have the same owner. See the Curo catalog (opens in a new tab).

Cardiogen (AEDR)

Not approvedBanned in sport

Also known as AEDR, Ala-Glu-Asp-Arg, Cardiogen, Cardiogen peptide

What it is

Synthetic analog, 4 amino acids

Approval

Not approved for any use

In sport

Banned in sport (WADA S0)

Studies

4 studies with results. 3 of them gave Cardiogen, with 13 results.
5 in animals8 in lab cells

Clinical trials

None registered

Community use

Community cardiac aging use

Dose as reported

Class

Species

Route

Duration

Design

Source

10(-12) M

Lab

rat

Not reported

Study on tissue taken from a body

Chalisova 2009

Context

Route

Amount

How often

How long

Agreement

Sources

Community cardiac aging use

subcutaneous injection

1 mg per dose

once daily

10 to 20 days

single source

Cardiogen (AEDR)

Cardiogen (AEDR) at a glance

What is Cardiogen?

Cardiogen (AEDR) structure and chemistry