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Study · Ex vivo tissue · rat · 2009

3 results

[The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats].

Chalisova NI, Lesniak VV, Balykina NA, Urt'eva SA, Urt'eva TA, Sukhonos IuA, Zhekalov AN

Advances in gerontology = Uspekhi gerontologii1 Jan 2009

PMID20210190 (opens in a new tab)PepBankPUB-20210190
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabEx vivo tissueActivity measurement

    In myocardial tissue cultures from young rats, cardiogen stimulated cell proliferation.

    In plain wordsIn lab tests with heart tissue from young rats, cardiogen increased cell proliferation.

    Peptide
    Cardiogen (AEDR)
    Outcome
    IncreaseCell proliferation in young myocardium
    Study

    ratn: not reported in source

    Myocardial explant cultures from 3-month-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-12) MAs given in this study (rat).

    Source sentences

    Summary
    The tetrapeptide cardiogen demonstrated the great stimulating effect on the proliferation both in tissues from young and old rats.
    1 context sentence
    Summary · context
    The effect of 20 amino acids and the synthetic tetrapeptide cardiogen in concentration 10(-12) M was investigated in organotypic tissue culture on the cell proliferation and apoptosis development in myocard tissue explant in 3- and 24-months old rats.
  2. 02LabEx vivo tissueActivity measurement

    In myocardial tissue cultures from old rats, cardiogen stimulated cell proliferation.

    In plain wordsIn lab tests with heart tissue from old rats, cardiogen increased cell proliferation.

    Peptide
    Cardiogen (AEDR)
    Outcome
    IncreaseCell proliferation in old myocardium
    Study

    ratn: not reported in source

    Myocardial explant cultures from 24-month-old rats
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    10(-12) MAs given in this study (rat).

    Source sentences

    Summary
    The tetrapeptide cardiogen demonstrated the great stimulating effect on the proliferation both in tissues from young and old rats.
    1 context sentence
    Summary · context
    The effect of 20 amino acids and the synthetic tetrapeptide cardiogen in concentration 10(-12) M was investigated in organotypic tissue culture on the cell proliferation and apoptosis development in myocard tissue explant in 3- and 24-months old rats.
  3. 03LabEx vivo tissueMechanism

    In rat myocardial tissue cultures, cardiogen decreased p53 protein expression.

    In plain wordsIn lab tests with rat heart tissue, cardiogen reduced p53 protein expression.

    Peptide
    Cardiogen (AEDR)
    Outcome
    Decreasep53 protein expression
    Study

    ratn: not reported in source

    Rat myocardial explant cultures
    Outcome group
    Receptor activity and mechanism · Cardiovascular
    Studied dose
    10(-12) MAs given in this study (rat).

    Source sentences

    Summary
    The immunohistochemical study demonstrated a decrease of the p53 protein expression by cardiogen action.
    1 context sentence
    Summary · context
    The effect of 20 amino acids and the synthetic tetrapeptide cardiogen in concentration 10(-12) M was investigated in organotypic tissue culture on the cell proliferation and apoptosis development in myocard tissue explant in 3- and 24-months old rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    21 Oct 2026, 17:05 UTC

    Study results updated

  2. Version 2

    21 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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