Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats.

Levdik NV, Knyazkin IV

Bulletin of experimental biology and medicine1 Sept 2009

PMID20396706DOI10.1007/s10517-010-0730-9PepBankPUB-20396706

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with M-1 sarcoma, Cardiogen increased tumor cell apoptosis compared with control in all experimental groups.
In plain wordsIn rats with tumors, Cardiogen increased tumor cell death compared with control.
Peptide
Cardiogen (AEDR)
Outcome
IncreaseTumor cell apoptosis
Study
ratn: not reported in source
transplanted M-1 sarcoma
Comparator
control
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · injectionAs given in this study (rat).
Source sentences
Summary
The level of apoptosis of tumor cells after cardiogen injections in all experimental groups was higher than in the control.
1 context sentence(design, population, supporting numbers)
Summary · context
The tumor-modifying effect of cardiogen peptide was studied on rats with transplanted M-1 sarcoma.
Report a problemFND-2039670601
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with M-1 sarcoma, Cardiogen inhibited tumor growth in a dose-dependent manner.
In plain wordsIn rats with tumors, Cardiogen reduced tumor growth, with an effect that depended on dose.
Peptide
Cardiogen (AEDR)
Outcome
DecreaseTumor growth
Study
ratn: not reported in source
transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · injectionAs given in this study (rat).
Source sentences
Summary
The dose-dependent inhibition of M-1 sarcoma growth after injection of cardiogen was caused by the development of hemorrhagic necrosis and stimulation of tumor cell apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
The tumor-modifying effect of cardiogen peptide was studied on rats with transplanted M-1 sarcoma.
Report a problemFND-2039670602
03AnimalAnimal study (in vivo)Mechanism
In rats with M-1 sarcoma, Cardiogen-associated growth inhibition involved hemorrhagic necrosis.
In plain wordsIn rats with tumors, Cardiogen-associated growth inhibition involved tissue death with bleeding.
Peptide
Cardiogen (AEDR)
Outcome
IncreaseHemorrhagic necrosis
Study
ratn: not reported in source
transplanted M-1 sarcoma
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated · injectionAs given in this study (rat).
Source sentences
Summary
The dose-dependent inhibition of M-1 sarcoma growth after injection of cardiogen was caused by the development of hemorrhagic necrosis and stimulation of tumor cell apoptosis.
1 context sentence(design, population, supporting numbers)
Summary · context
The tumor-modifying effect of cardiogen peptide was studied on rats with transplanted M-1 sarcoma.
Report a problemFND-2039670603
04AnimalAnimal study (in vivo)Mechanism
In rats with M-1 sarcoma, proliferative activity parameters indicated no direct cytostatic basis for Cardiogen-associated tumor growth inhibition.
In plain wordsIn rats with tumors, measurements indicated that Cardiogen did not inhibit growth through a direct cytostatic effect.
Peptide
Cardiogen (AEDR)
Outcome
No significant changeDirect cytostatic effect
Study
ratn: not reported in source
transplanted M-1 sarcoma
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated · injectionAs given in this study (rat).
Source sentences
Summary
The parameters of proliferative activity indicate that inhibition of tumor growth was not caused by the direct cytostatic effect of the drug on the tumor.
1 context sentence(design, population, supporting numbers)
Summary · context
The tumor-modifying effect of cardiogen peptide was studied on rats with transplanted M-1 sarcoma.
Report a problemFND-2039670604
05AnimalAnimal study (in vivo)Mechanism
In rats with M-1 sarcoma, morphological signs indicated Cardiogen action through the tumor vascular network.
In plain wordsIn rats with tumors, tissue features indicated that Cardiogen acted through tumor blood vessels.
Peptide
Cardiogen (AEDR)
Outcome
Not applicableTumor vascular mechanism
Study
ratn: not reported in source
transplanted M-1 sarcoma
Outcome group
Receptor activity and mechanism · Cancer
Studied dose
Dose not stated · injectionAs given in this study (rat).
Source sentences
Summary
Morphological signs indicate a specific mechanism of cardiogen action, realized through the vascular network of the tumor.
1 context sentence(design, population, supporting numbers)
Summary · context
The tumor-modifying effect of cardiogen peptide was studied on rats with transplanted M-1 sarcoma.
Report a problemFND-2039670605

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 16:35 UTC
Study data updated · source update from Europe PMC
Version 2
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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