Skip to content
Apraglutide / Studies
Synthetic analog · 33 amino acids

Apraglutide studies and research data

PepBank has 16 apraglutide studies with results. 15 of them gave apraglutide, with 110 results, grouped by what the studies measured. In each group, results from studies in people come first. Data as of 2026-10-30.

Searches 110 results and 26 papers. Newer studies from Europe PMC

Results in people
58
53% of 110 results
Results in animals
47
43% of 110 results
Results in lab cells
5
5% of 110 results
From computer models
0
0% of 110 results
The molecule

Apraglutide identity

Identifiers, parent molecule, targets and development stage, from curated data.

Apraglutide is a synthetic 33-residue GLP-2 analog. It differs from teduglutide and glepaglutide. Studies include intestinal absorption and adaptation models.

Kind
Synthetic analog · 33 residues
Identifiers
ChEMBLCHEMBL4563522 (opens in a new tab)UNIICVQ1IAY2G6 (opens in a new tab)CAS1295353-98-8IUPHAR10685 (opens in a new tab)
Parent
Analog of Human GLP-2 · residues 146-178UniProt places native human GLP-2 at precursor residues 146-178. Primary publications report Gly2, Nle10, D-Phe11 and Leu16 substitutions and C-terminal amidation. The complete analog structure remains disputed across sources.
Development
Phase 3Ironwood PharmaceuticalsIronwood reported active recruitment for confirmatory phase 3 STARS-2 on 6 August 2026. This dated sponsor report does not establish recruitment status on the review date. Source (opens in a new tab)

Targets

Molecular targets with action and evidence source
TargetActionEvidence
GLP2RGLP2RO95838 (opens in a new tab)AgonistPrimary receptor potency and selectivity experiments establish GLP-2 receptor agonism.Source (opens in a new tab)

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

Sequence not disclosed

Primary publications identify [Gly2,Nle10,D-Phe11,Leu16]hGLP-2(1-33)-NH2 and report molecular weight 3765. IUPHAR/PubChem instead describe Ahx at position 10. GSRS encodes a norleucine modification at position 10 but reports different chemistry properties. ChEMBL reports C172H263N43O52 and 3765.24 Da. GSRS reports estimated C172H264O48N46 and 3760 Da. Full sequence, formula, mass and structure identifiers remain unset because these records conflict. The primary sequence contains no cysteine or cyclization.

Parent: Human GLP-2

No sequence is listed for the parent, so no alignment is shown.UniProt places native human GLP-2 at precursor residues 146-178. Primary publications report Gly2, Nle10, D-Phe11 and Leu16 substitutions and C-terminal amidation. The complete analog structure remains disputed across sources.

Properties

From identity sources

No formula or molecular weight is listed for Apraglutide.

Calculated from the sequence

No sequence is listed, so nothing can be calculated.

Net charge by pH

No charge curve

No sequence is listed for this peptide.

Composition

No sequence is listed for this peptide.

3D structure

PredictedAlphaFold DB · P01275

Loads the 3D viewer (3Dmol.js, about 150 KB) and the model file from AlphaFold DB (EMBL-EBI).

  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

Predicted model of the whole UniProt entry P01275, not an experimental structure of Apraglutide. Apraglutide = residues 146–178.

AlphaFold DB, EMBL-EBI and Google DeepMind · CC BY 4.0

Results by area

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

Trials and papers
Status and safety
Data