Comparing the Intestinotrophic Effects of 2 Glucagon-Like Peptide-2 Analogues in the Treatment of Short-Bowel Syndrome in Neonatal Piglets.

Pauline ML, Nation PN, Wizzard PR, Hinchliffe T, Wu T, Dimitriadou V, Turner JM, Wales PW

JPEN. Journal of parenteral and enteral nutrition21 May 2020Cited by 10 (Europe PMC)

PMID32437048DOI10.1002/jpen.1853PepBankPUB-32437048

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study19

19 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Pharmacokinetics
In neonatal SBS piglets, apraglutide and teduglutide had different PK profiles.
In plain wordsIn piglets with SBS, apraglutide and teduglutide had different drug exposure profiles.
Peptide
Apraglutide
Outcome
Direction not reportedPK profile
Study
pign = 23
neonatal short-bowel syndrome
Comparator
teduglutide
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
5 mg/kg/dose twice weeklyAs given in this study (pig).
Source sentences
Summary
PK profiles were different between the 2 analogues.
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA) METHODS:
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8),
Report a problemFND-3243704801
02AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, apraglutide increased small-bowel length versus saline.
In plain wordsIn piglets with SBS, apraglutide increased small-bowel length versus saline.
Peptide
Apraglutide
Outcome
IncreaseSmall-bowel length
Study
pign = 16
neonatal short-bowel syndrome
Comparator
saline
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
5 mg/kg/dose twice weeklyAs given in this study (pig).
Measurements
Small-bowel length
166 cm
APRA
Small-bowel length
141 cm
CON
Source sentences
Summary
Compared with CON, APRA and TEDBID increased small-bowel length (cm) (CON: 141, APRA: 166, TED: 153, TEDBID: 165; P = .004)
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA) METHODS:
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8),
Report a problemFND-3243704803
03AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, apraglutide increased small-bowel weight versus saline.
In plain wordsIn piglets with SBS, apraglutide increased small-bowel weight versus saline.
Peptide
Apraglutide
Outcome
IncreaseSmall-bowel weight
Study
pign = 16
neonatal short-bowel syndrome
Comparator
saline
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
5 mg/kg/dose twice weeklyAs given in this study (pig).
Measurements
Small-bowel weight
33 g
APRA
Small-bowel weight
26 g
CON
Source sentences
Summary
whereas APRA increased small-bowel weight (g) (CON: 26, APRA: 33, TED: 28, TEDBID: 31; P = .007)
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA) METHODS:
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8),
Report a problemFND-3243704804
04AnimalAnimal study (in vivo)Efficacy outcome
In neonatal SBS piglets, apraglutide increased villus height versus saline.
In plain wordsIn piglets with SBS, apraglutide increased intestinal villus height versus saline.
Peptide
Apraglutide
Outcome
IncreaseVillus height
Study
pign = 16
neonatal short-bowel syndrome
Comparator
saline
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
5 mg/kg/dose twice weeklyAs given in this study (pig).
Measurements
Villus height
0.9 mm
APRA
Villus height
0.59 mm
CON
Source sentences
Summary
and villus height (mm) (CON: 0.59, APRA: 0.90, TED: 0.58, TEDBID: 0.74; P < .001).
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA) METHODS:
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8),
Report a problemFND-3243704805
05AnimalAnimal study (in vivo)Efficacy outcome
At day 7, small-bowel length was 153 cm with once-daily teduglutide and 141 cm with saline; significance was not stated for this contrast.
In plain wordsIn piglets, bowel length was numerically greater with once-daily teduglutide than saline at day 7.
Peptide
Teduglutide
Outcome
IncreaseSmall-bowel length, once daily
Study
pign = 16
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Saline
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
Length
153 cm
TED
Length
141 cm
CON
Source sentences
Summary
Compared with CON, APRA and TEDBID increased small-bowel length (cm) (CON: 141, APRA: 166, TED: 153, TEDBID: 165; P = .004)
3 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704808
06AnimalAnimal study (in vivo)Efficacy outcome
At day 7, bowel weight was 28 g with once-daily teduglutide versus 26 g with saline; significance was not stated for this contrast.
In plain wordsIn piglets, bowel weight was numerically higher with once-daily teduglutide than saline at day 7.
Peptide
Teduglutide
Outcome
IncreaseSmall-bowel weight, once daily
Study
pign = 16
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Saline
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
Weight
28 g
TED
Weight
26 g
CON
Source sentences
Summary
whereas APRA increased small-bowel weight (g) (CON: 26, APRA: 33, TED: 28, TEDBID: 31; P = .007)
3 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704810
07AnimalAnimal study (in vivo)Efficacy outcome
At day 7, villus height was 0.58 mm with once-daily teduglutide versus 0.59 mm with saline; significance was not stated for this contrast.
In plain wordsIn piglets, villus height was numerically lower with once-daily teduglutide than saline at day 7.
Peptide
Teduglutide
Outcome
DecreaseVillus height, once daily
Study
pign = 16
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Saline
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
Villus height
0.58 mm
TED
Villus height
0.59 mm
CON
Source sentences
Summary
and villus height (mm) (CON: 0.59, APRA: 0.90, TED: 0.58, TEDBID: 0.74; P < .001).
3 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704812
08AnimalAnimal study (in vivo)Efficacy outcome
In piglets at day 7, small-bowel length was 153 cm with once-daily teduglutide versus 166 cm with apraglutide.
In plain wordsIn piglets at day 7, small-bowel length was numerically lower with once-daily teduglutide than with apraglutide.
Peptide
Teduglutide
Outcome
Decreasesmall-bowel length, once-daily versus apraglutide
Study
pign = 16
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
small-bowel length
153 cm
once-daily teduglutide
small-bowel length
166 cm
apraglutide
Source sentences
Summary
Compared with CON, APRA and TEDBID increased small-bowel length (cm) (CON: 141, APRA: 166, TED: 153, TEDBID: 165; P = .004)
2 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704814
09AnimalAnimal study (in vivo)Efficacy outcome
In piglets at day 7, small-bowel weight was 28 g with once-daily teduglutide versus 33 g with apraglutide.
In plain wordsIn piglets at day 7, small-bowel weight was numerically lower with once-daily teduglutide than with apraglutide.
Peptide
Teduglutide
Outcome
Decreasesmall-bowel weight, once-daily versus apraglutide
Study
pign = 16
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
small-bowel weight
28 g
once-daily teduglutide
small-bowel weight
33 g
apraglutide
Source sentences
Summary
whereas APRA increased small-bowel weight (g) (CON: 26, APRA: 33, TED: 28, TEDBID: 31; P = .007)
2 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704816
10AnimalAnimal study (in vivo)Efficacy outcome
In piglets at day 7, villus height was 0.58 mm with once-daily teduglutide versus 0.9 mm with apraglutide.
In plain wordsIn piglets at day 7, villus height was numerically lower with once-daily teduglutide than with apraglutide.
Peptide
Teduglutide
Outcome
Decreasevillus height, once-daily versus apraglutide
Study
pign = 16
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
villus height
0.58 mm
once-daily teduglutide
villus height
0.9 mm
apraglutide
Source sentences
Summary
and villus height (mm) (CON: 0.59, APRA: 0.90, TED: 0.58, TEDBID: 0.74; P < .001).
2 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704818
11AnimalAnimal study (in vivo)Pharmacokinetics
In neonatal SBS piglets, teduglutide required twice daily injection to achieve exposure comparable to apraglutide.
In plain wordsIn piglets with SBS, teduglutide needed twice daily injections for exposure comparable to apraglutide.
Peptide
Apraglutide
Outcome
Not applicableComparable exposure
Study
pign = 15
neonatal short-bowel syndrome
Comparator
teduglutide twice daily
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
5 mg/kg/dose twice weeklyAs given in this study (pig).
Source sentences
Summary
To achieve a comparable exposure to APRA, TED requires twice daily injection (TEDBID).
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA) METHODS:
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8),
Report a problemFND-3243704802
12AnimalAnimal study (in vivo)Efficacy outcome
At day 7, twice-daily teduglutide increased small-bowel length versus saline in piglets (165 versus 141 cm).
In plain wordsIn piglets, twice-daily teduglutide increased bowel length compared with saline at day 7.
Peptide
Teduglutide
Outcome
IncreaseSmall-bowel length, twice daily
Study
pign = 15
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Saline
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
Length
165 cm
TEDBID
Length
141 cm
CON
Source sentences
Summary
Compared with CON, APRA and TEDBID increased small-bowel length (cm) (CON: 141, APRA: 166, TED: 153, TEDBID: 165; P = .004)
3 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704809
13AnimalAnimal study (in vivo)Efficacy outcome
At day 7, bowel weight was 31 g with twice-daily teduglutide versus 26 g with saline; significance was not stated for this contrast.
In plain wordsIn piglets, bowel weight was numerically higher with twice-daily teduglutide than saline at day 7.
Peptide
Teduglutide
Outcome
IncreaseSmall-bowel weight, twice daily
Study
pign = 15
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Saline
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
Weight
31 g
TEDBID
Weight
26 g
CON
Source sentences
Summary
whereas APRA increased small-bowel weight (g) (CON: 26, APRA: 33, TED: 28, TEDBID: 31; P = .007)
3 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704811
14AnimalAnimal study (in vivo)Efficacy outcome
At day 7, villus height was 0.74 mm with twice-daily teduglutide versus 0.59 mm with saline; significance was not stated for this contrast.
In plain wordsIn piglets, villus height was numerically higher with twice-daily teduglutide than saline at day 7.
Peptide
Teduglutide
Outcome
IncreaseVillus height, twice daily
Study
pign = 15
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Saline
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
Villus height
0.74 mm
TEDBID
Villus height
0.59 mm
CON
Source sentences
Summary
and villus height (mm) (CON: 0.59, APRA: 0.90, TED: 0.58, TEDBID: 0.74; P < .001).
3 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704813
15AnimalAnimal study (in vivo)Efficacy outcome
In piglets at day 7, small-bowel length was 165 cm with twice-daily teduglutide versus 166 cm with apraglutide.
In plain wordsIn piglets at day 7, small-bowel length was numerically lower with twice-daily teduglutide than with apraglutide.
Peptide
Teduglutide
Outcome
Decreasesmall-bowel length, twice-daily versus apraglutide
Study
pign = 15
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
small-bowel length
165 cm
twice-daily teduglutide
small-bowel length
166 cm
apraglutide
Source sentences
Summary
Compared with CON, APRA and TEDBID increased small-bowel length (cm) (CON: 141, APRA: 166, TED: 153, TEDBID: 165; P = .004)
2 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704815
16AnimalAnimal study (in vivo)Efficacy outcome
In piglets at day 7, small-bowel weight was 31 g with twice-daily teduglutide versus 33 g with apraglutide.
In plain wordsIn piglets at day 7, small-bowel weight was numerically lower with twice-daily teduglutide than with apraglutide.
Peptide
Teduglutide
Outcome
Decreasesmall-bowel weight, twice-daily versus apraglutide
Study
pign = 15
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
small-bowel weight
31 g
twice-daily teduglutide
small-bowel weight
33 g
apraglutide
Source sentences
Summary
whereas APRA increased small-bowel weight (g) (CON: 26, APRA: 33, TED: 28, TEDBID: 31; P = .007)
2 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704817
17AnimalAnimal study (in vivo)Efficacy outcome
In piglets at day 7, villus height was 0.74 mm with twice-daily teduglutide versus 0.9 mm with apraglutide.
In plain wordsIn piglets at day 7, villus height was numerically lower with twice-daily teduglutide than with apraglutide.
Peptide
Teduglutide
Outcome
Decreasevillus height, twice-daily versus apraglutide
Study
pign = 15
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Intestinal Adaptation · Gastrointestinal
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Measurements
villus height
0.74 mm
twice-daily teduglutide
villus height
0.9 mm
apraglutide
Source sentences
Summary
and villus height (mm) (CON: 0.59, APRA: 0.90, TED: 0.58, TEDBID: 0.74; P < .001).
2 context sentences(design, population, supporting numbers)
Summary · context
Pharmacokinetic (PK) studies were undertaken, and on day 7, small-intestinal length and weight were measured and jejunal tissue collected for histology.
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704819
18AnimalAnimal study (in vivo)Pharmacokinetics
In neonatal piglets with SBS, teduglutide and apraglutide had different pharmacokinetic profiles.
In plain wordsIn piglets with short bowel syndrome, teduglutide and apraglutide had different drug-exposure profiles.
Peptide
Teduglutide
Outcome
MixedPK profile
Study
pign: not reported in source
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Source sentences
Summary
PK profiles were different between the 2 analogues.
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704806
19AnimalAnimal study (in vivo)Pharmacokinetics
In neonatal piglets with SBS, teduglutide required twice-daily injections to achieve exposure comparable to apraglutide.
In plain wordsIn piglets with short bowel syndrome, teduglutide needed twice-daily injections for exposure comparable to apraglutide.
Peptide
Teduglutide
Outcome
Not applicableDosing frequency for comparable exposure
Study
pign: not reported in source
Neonatal piglets after 75% distal small-intestinal resection
Comparator
Apraglutide
Outcome group
Pharmacokinetics · Pharmacology
Studied dose
0.05 mg/kg/doseAs given in this study (pig).
Source sentences
Summary
To achieve a comparable exposure to APRA, TED requires twice daily injection (TEDBID).
2 context sentences(design, population, supporting numbers)
Summary · context
In neonatal piglets with SBS, we compared intestinal adaptation following treatment with 2 GLP-2 analogues: teduglutide (TED) and apraglutide (APRA)
Summary · context
Following 75% distal small-intestinal resection, piglets were allocated to 4 treatment groups: saline (CON: n = 8), twice weekly APRA (5 mg/kg/dose; n = 8), and TED once daily (TED, 0.05 mg/kg/dose; n = 8) or twice daily (TEDBID, 0.05 mg/kg/dose; n = 7).
Report a problemFND-3243704807

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 2
27 Oct 2026, 16:37 UTC
Study data updated · source update from Europe PMC
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Comparing the Intestinotrophic Effects of 2 Glucagon-Like Peptide-2 Analogues in the Treatment of Short-Bowel Syndrome in Neonatal Piglets.

Summary

Results from this study19

Version history

Subjects

Publication types

MeSH terms

Keywords