In neonatal short-bowel piglets, intestinal length further increased after apraglutide cessation at day 14.
In plain wordsIn piglets with short bowel, intestinal length increased further at day 14 after apraglutide treatment stopped.
- Peptide
- Apraglutide
- Outcome
- IncreaseIntestinal length after treatment cessation
- Study
pign: not reported in source
neonatal short-bowel piglets- Comparator
- day 7 endpoint
- Outcome group
- Gastrointestinal protection · Gastrointestinal
- Studied dose
- 5 mg/kg twice weekly · 7 daysAs given in this study (pig).
Source sentences
Treatment increased intestinal growth in length by day 7 (P = .005), which was maintained (by T) or further increased (by A) at day 14 (P < .001).
2 context sentences(design, population, supporting numbers)
Neonatal short-bowel piglets were assigned to saline control (S), 7-day treatment with teduglutide (T) (0.05 mg/kg twice daily), or 7-day treatment with apraglutide (A) (5 mg/kg twice weekly).
Comparisons were made between day 7 and day 14 endpoints using analysis of variance.