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Study · Animal study (in vivo) · mouse · 2024

9 results

The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival After Chemotherapy and Allogeneic Transplantation in Mice.

Minden MD, Audiger C, Chabot-Roy G, Lesage S, Delisle JS, Biemans B, Dimitriadou V

Annals of transplantation5 Nov 2024Cited by 5 (Europe PMC)

PMID39497378 (opens in a new tab)PMCIDPMC11549896 (opens in a new tab)DOI10.12659/aot.945249 (opens in a new tab)PepBankPUB-39497378
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study9

9 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice receiving chemotherapy, apraglutide improved survival versus chemotherapy alone.

    In plain wordsIn mice receiving chemotherapy, apraglutide improved survival versus chemotherapy alone.

    Peptide
    Apraglutide
    Outcome
    IncreaseSurvival after chemotherapy
    Study

    mousen: not reported in source

    chemotherapy-induced intestinal damage
    Comparator
    chemotherapy alone
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RESULTS Adding apraglutide to chemotherapy significantly improved survival rates and reduced weight loss, with no impact on leukocyte counts (and, therefore, no effect on chemotherapy-induced immunosuppression), compared with chemotherapy alone in mice.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice receiving chemotherapy, apraglutide reduced weight loss versus chemotherapy alone.

    In plain wordsIn mice receiving chemotherapy, apraglutide reduced weight loss versus chemotherapy alone.

    Peptide
    Apraglutide
    Outcome
    DecreaseWeight loss after chemotherapy
    Study

    mousen: not reported in source

    chemotherapy-induced intestinal damage
    Comparator
    chemotherapy alone
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RESULTS Adding apraglutide to chemotherapy significantly improved survival rates and reduced weight loss, with no impact on leukocyte counts (and, therefore, no effect on chemotherapy-induced immunosuppression), compared with chemotherapy alone in mice.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  3. 03AnimalAnimal study (in vivo)Other

    In mice receiving chemotherapy, apraglutide did not affect leukocyte counts versus chemotherapy alone.

    In plain wordsIn mice receiving chemotherapy, apraglutide did not affect leukocyte counts versus chemotherapy alone.

    Peptide
    Apraglutide
    Outcome
    No significant changeLeukocyte counts
    Study

    mousen: not reported in source

    chemotherapy-induced intestinal damage
    Comparator
    chemotherapy alone
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    RESULTS Adding apraglutide to chemotherapy significantly improved survival rates and reduced weight loss, with no impact on leukocyte counts (and, therefore, no effect on chemotherapy-induced immunosuppression), compared with chemotherapy alone in mice.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In chemotherapy-treated mice, apraglutide benefits were associated with preserved GI mucosal integrity.

    In plain wordsIn mice receiving chemotherapy, apraglutide benefits were associated with preserved gut lining integrity.

    Peptide
    Apraglutide
    Outcome
    IncreaseGI mucosal integrity
    Study

    mousen: not reported in source

    chemotherapy-induced intestinal damage
    Comparator
    chemotherapy alone
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These benefits were associated with preservation of the morphological integrity of the GI mucosa, attenuation of the negative impact of cytarabine on the intestinal microbiota, and significant improvement in plasma levels of citrulline.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, apraglutide attenuated the negative impact of cytarabine on intestinal microbiota.

    In plain wordsIn mice, apraglutide reduced the negative effects of cytarabine on gut bacteria.

    Peptide
    Apraglutide
    Outcome
    DecreaseIntestinal microbiota damage
    Study

    mousen: not reported in source

    chemotherapy-induced intestinal damage
    Comparator
    chemotherapy alone
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These benefits were associated with preservation of the morphological integrity of the GI mucosa, attenuation of the negative impact of cytarabine on the intestinal microbiota, and significant improvement in plasma levels of citrulline.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  6. 06AnimalAnimal study (in vivo)Activity measurement

    In chemotherapy-treated mice, apraglutide benefits were associated with improved plasma citrulline levels.

    In plain wordsIn mice receiving chemotherapy, apraglutide benefits were associated with improved blood citrulline levels.

    Peptide
    Apraglutide
    Outcome
    Direction not reportedPlasma citrulline
    Study

    mousen: not reported in source

    chemotherapy-induced intestinal damage
    Comparator
    chemotherapy alone
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    These benefits were associated with preservation of the morphological integrity of the GI mucosa, attenuation of the negative impact of cytarabine on the intestinal microbiota, and significant improvement in plasma levels of citrulline.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice receiving allogeneic transplantation, apraglutide improved survival versus groups without apraglutide.

    In plain wordsIn irradiated mice receiving transplantation, apraglutide improved survival versus groups without apraglutide.

    Peptide
    Apraglutide
    Outcome
    IncreaseSurvival after transplantation
    Study

    mousen: not reported in source

    irradiation followed by allogeneic transplantation
    Comparator
    groups without apraglutide
    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, in a model of irradiation followed by allogeneic transplantation, mice in groups receiving apraglutide had improved survival, reduced weight loss, and increased colon length compared with those that did not.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice receiving allogeneic transplantation, apraglutide reduced weight loss versus groups without apraglutide.

    In plain wordsIn irradiated mice receiving transplantation, apraglutide reduced weight loss versus groups without apraglutide.

    Peptide
    Apraglutide
    Outcome
    DecreaseWeight loss after transplantation
    Study

    mousen: not reported in source

    irradiation followed by allogeneic transplantation
    Comparator
    groups without apraglutide
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, in a model of irradiation followed by allogeneic transplantation, mice in groups receiving apraglutide had improved survival, reduced weight loss, and increased colon length compared with those that did not.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice receiving allogeneic transplantation, apraglutide increased colon length versus groups without apraglutide.

    In plain wordsIn irradiated mice receiving transplantation, apraglutide increased colon length versus groups without apraglutide.

    Peptide
    Apraglutide
    Outcome
    IncreaseColon length after transplantation
    Study

    mousen: not reported in source

    irradiation followed by allogeneic transplantation
    Comparator
    groups without apraglutide
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, in a model of irradiation followed by allogeneic transplantation, mice in groups receiving apraglutide had improved survival, reduced weight loss, and increased colon length compared with those that did not.
    2 context sentences
    Summary · context
    Here, we examined the GI-protective effects of apraglutide, a long-acting peptide GLP-2 analog, in murine models of chemotherapy, and total body irradiation followed by allogeneic transplantation.
    Summary · context
    MATERIAL AND METHODS The impact of apraglutide on cytarabine or melphalan chemotherapy-induced intestinal damage was assessed in BALB/c mice, and the effect on allogeneic transplantation in BALB/cJ and C57BL/6J mice.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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