Setmelanotide studies: 62 papers with results
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- Targeting melanocortin 4 receptor to treat sleep-disordered breathing in mice.
Amorim MR · The Journal of clinical investigation · 2025
Animal study (in vivo) · mouse · 3 results
- The MC4R agonist, setmelanotide, is associated with an improvement in hypercapnic chemosensitivity and weight loss in male mice.
Rivera A · Respiratory physiology & neurobiology · 2025
Animal study (in vivo) · mouse · 7 results
- SAR investigation and synergistic optimization of setmelanotide yields a potent, selective, and soluble MC4R agonist.
Guo C · Bioorganic chemistry · 2026
Animal study (in vivo) · 2 results
- Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.
Guo C · Journal of medicinal chemistry · 2026
Animal study (in vivo) · mouse · 2 results
- Setmelanotide alleviates diabetes-associated cognitive impairment by interrupting the binding of ICAM-1 and JIP1 in endothelial cells of the blood-brain barrier.
Wu SD · Metabolism: clinical and experimental · 2026
Animal study (in vivo) · mouse · 4 results
- Setmelanotide-mediated MC4R activation improves hypothalamic obesity via CaMKK2/AMPK pathways.
Peng J · Frontiers in pharmacology · 2025
Animal study (in vivo) · rat · 5 results
- SAT-299 Chronic Treatment Of Juvenile Hypothalamic Pomc-deficient Mice With RM-493 Prevents The Development Of Obesity
Thompson Z · Journal of the Endocrine Society · 2020
Animal study (in vivo) · mouse · 7 results
- Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype.
Kamermans A · Frontiers in immunology · 2019
In vitro (cells) · 5 results
- MC4R Variants Modulate α-MSH and Setmelanotide Induced Cellular Signaling at Multiple Levels.
Rodríguez Rondón AV · The Journal of clinical endocrinology and metabolism · 2024
In vitro (cells) · 3 results
- Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor.
Hammad MM · Life sciences · 2022
In vitro (cells) · 2 results
- Structures of active melanocortin-4 receptor-Gs-protein complexes with NDP-α-MSH and setmelanotide.
Heyder NA · Cell research · 2021
Not a test of Setmelanotide alone · 2 results
- Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling.
Israeli H · Science (New York, N.Y.) · 2021
Not a test of Setmelanotide alone · 2 results