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Study · Animal study (in vivo) · mouse · 2026

2 results

Discovery of TL10: A Soluble and Long-Acting MC4R Agonist with Tunable Lipidation for Sustained Pharmacological Activity.

Guo C, Luo T, Dong Y, Lu J, Zhao F, Bian J, Xu Z, Feng J

Journal of medicinal chemistry1 Aug 2026

PMID42611594 (opens in a new tab)DOI10.1021/acs.jmedchem.6c01457 (opens in a new tab)PepBankPUB-42611594
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, daily setmelanotide produced weight loss that TL10 every third day matched or exceeded under the tested conditions.

    In plain wordsIn obese mice, TL10 every third day matched or exceeded weight loss with daily setmelanotide.

    Peptide
    Setmelanotide
    Outcome
    MixedWeight loss
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Comparator
    TL10 Q3D
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Daily administrationAs given in this study (mouse).

    Source sentences

    Summary
    In diet-induced obese mice, Q3D administration of TL10 elicited sustained weight loss and appetite suppression, matching or exceeding daily setmelanotide under the tested conditions.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, daily setmelanotide suppressed appetite to an extent matched or exceeded by TL10 every third day.

    In plain wordsIn obese mice, TL10 every third day matched or exceeded appetite suppression with daily setmelanotide.

    Peptide
    Setmelanotide
    Outcome
    MixedAppetite suppression
    Study

    mousen: not reported in source

    Diet-induced obese mice
    Comparator
    TL10 Q3D
    Outcome group
    Appetite and food intake · Metabolic and weight
    Studied dose
    Daily administrationAs given in this study (mouse).

    Source sentences

    Summary
    In diet-induced obese mice, Q3D administration of TL10 elicited sustained weight loss and appetite suppression, matching or exceeding daily setmelanotide under the tested conditions.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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