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Study · Animal study (in vivo) · 2026

2 results

SAR investigation and synergistic optimization of setmelanotide yields a potent, selective, and soluble MC4R agonist.

Guo C, Luo T, Dong Y, Lu J, Xu Z, Bian J, Feng X, Chen A, Chen D, Feng J

Bioorganic chemistry14 Dec 2025Cited by 1 (Europe PMC)

PMID41401696 (opens in a new tab)DOI10.1016/j.bioorg.2025.109370 (opens in a new tab)PepBankPUB-41401696
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a diet-induced obesity model, setmelanotide and SC19 had comparable efficacy in reducing weight gain.

    In plain wordsIn animals with diet-induced obesity, setmelanotide and SC19 reduced weight gain comparably.

    Peptide
    Setmelanotide
    Outcome
    No significant changeWeight gain
    Study

    n: not reported in source

    Diet-induced obesity model
    Comparator
    SC19
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a diet-induced obesity model, SC19 demonstrated robust efficacy comparable to setmelanotide in reducing weight gain and improving lipid profiles, affirming its therapeutic potential.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a diet-induced obesity model, setmelanotide and SC19 had comparable efficacy in improving lipid profiles.

    In plain wordsIn animals with diet-induced obesity, setmelanotide and SC19 improved blood fat profiles comparably.

    Peptide
    Setmelanotide
    Outcome
    No significant changeLipid profile
    Study

    n: not reported in source

    Diet-induced obesity model
    Comparator
    SC19
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a diet-induced obesity model, SC19 demonstrated robust efficacy comparable to setmelanotide in reducing weight gain and improving lipid profiles, affirming its therapeutic potential.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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