Study · Animal study (in vivo) · mouse · 2026
4 resultsWu SD, Wang X, Zhou YM, Hu B, Wang KY, Yan CJ, Zhu HY, Li H, Wang XC, Wang HP, Cheng AF, Zhu ZS, Ying CJ, Zhou XY
Metabolism: clinical and experimental24 Jul 2026
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Text rights: Publisher copyright. Results still quote short attributed sentences.
4 results from studies that gave the peptide. No result from this study comes from people.
In diabetic mice, setmelanotide mitigated blood-brain barrier damage.
In plain wordsIn mice with diabetes, setmelanotide reduced damage to the blood-brain barrier.
mousen: not reported in source
Diabetic miceSource sentences
In diabetic mice, setmelanotide mitigated BBB damage and the resulting cognitive impairment.
In diabetic mice, setmelanotide mitigated cognitive impairment associated with blood-brain barrier damage.
In plain wordsIn mice with diabetes, setmelanotide reduced cognitive impairment.
mousen: not reported in source
Diabetic miceSource sentences
In diabetic mice, setmelanotide mitigated BBB damage and the resulting cognitive impairment.
In endothelial cells, setmelanotide maintained tight junction integrity through reduced ICAM-1 and JIP1 interaction.
In plain wordsIn cells, setmelanotide helped maintain the integrity of endothelial tight junctions.
n: not reported in source
Source sentences
After binding-site screening, setmelanotide was selected for study and was found to significantly reduce the interaction between ICAM-1 and JIP1, thereby allowing the integrity of EC tight junctions to be maintained.
In lab tests, setmelanotide significantly reduced the interaction between ICAM-1 and JIP1.
In plain wordsIn lab tests, setmelanotide reduced binding between ICAM-1 and JIP1.
n: not reported in source
Source sentences
After binding-site screening, setmelanotide was selected for study and was found to significantly reduce the interaction between ICAM-1 and JIP1, thereby allowing the integrity of EC tight junctions to be maintained.
Using GST pull-down assays, surface plasmon resonance (SPR), isothermal titration calorimetry (ITC), and other methods, we found that the intracellular segment residues 522-526 of ICAM-1 bind directly to the phosphotyrosine interaction domain (PID) of JNK interacting protein 1 (JIP1; residues 586-593).
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PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.
Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC
Terms as the source lists them.
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