Skip to content

Study · In vitro (cells) · 2022

2 results

Structural analysis of setmelanotide binding to MC4R variants in comparison to wild-type receptor.

Hammad MM, Mohammad A, Alam-Eldin N, Madhu D, Al-Mulla F, Abu-Farha M, Abubaker J

Life sciences2 Aug 2022Cited by 9 (Europe PMC)

PMID35931197 (opens in a new tab)DOI10.1016/j.lfs.2022.120857 (opens in a new tab)PepBankPUB-35931197
Publisher pagePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEK293-MC4R cells, setmelanotide had higher potency for cAMP formation than α-MSH.

    In plain wordsIn cells, setmelanotide stimulated cAMP formation more potently than α-MSH.

    Peptide
    Setmelanotide
    Outcome
    IncreasecAMP formation potency
    Study

    humann: not reported in source

    HEK293-MC4R cells
    Comparator
    α-MSH
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data shows that setmelanotide has a higher potency for cAMP formation and a weaker effect on ERK1/2 phosphorylation when compared to α-MSH indicating functional selectivity otherwise known as biased agonism.
    1 context sentence
    Summary · context
    HEK293-MC4R were utilized in the functional analysis of MC4R-actiavted pathways upon stimulating with α-MSH or setmelanotide.
  2. 02LabIn vitro (cells)Activity measurement

    In HEK293-MC4R cells, setmelanotide had a weaker effect on ERK1/2 phosphorylation than α-MSH.

    In plain wordsIn cells, setmelanotide had a weaker effect on ERK phosphorylation than α-MSH.

    Peptide
    Setmelanotide
    Outcome
    DecreaseERK phosphorylation
    Study

    humann: not reported in source

    HEK293-MC4R cells
    Comparator
    α-MSH
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our data shows that setmelanotide has a higher potency for cAMP formation and a weaker effect on ERK1/2 phosphorylation when compared to α-MSH indicating functional selectivity otherwise known as biased agonism.
    1 context sentence
    Summary · context
    HEK293-MC4R were utilized in the functional analysis of MC4R-actiavted pathways upon stimulating with α-MSH or setmelanotide.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:36 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.