SAT-299 Chronic Treatment Of Juvenile Hypothalamic Pomc-deficient Mice With RM-493 Prevents The Development Of Obesity

Thompson Z, Shah B, Low M

Journal of the Endocrine Society8 May 2020

PMCIDPMC7208318PepBankPUB-90968144

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In Arc-Pomc knockout mice, chronic RM-493 reduced body weight versus the switch group at 24 weeks of age (p<0.05).
In plain wordsIn mice lacking hypothalamic Pomc, chronic RM-493 reduced weight versus the switch group at 24 weeks of age.
Peptide
Setmelanotide
Outcome
DecreaseBody weight at 24 weeks of age
Study
mousen: not reported in source
Arc-Pomc knockout mice
Comparator
Switch group
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
Among other results, at the end of the study (24 weeks of age), Arc-Pomc knockout mice in the RM-493 group weighed significantly less than either the switch or vehicle groups (p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814401
02AnimalAnimal study (in vivo)Efficacy outcome
In Arc-Pomc knockout mice, chronic RM-493 reduced body weight versus vehicle at 24 weeks of age (p<0.05).
In plain wordsIn mice lacking hypothalamic Pomc, chronic RM-493 reduced weight versus vehicle at 24 weeks of age.
Peptide
Setmelanotide
Outcome
DecreaseBody weight at 24 weeks of age
Study
mousen: not reported in source
Arc-Pomc knockout mice
Comparator
Vehicle group
Outcome group
Body weight · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
Among other results, at the end of the study (24 weeks of age), Arc-Pomc knockout mice in the RM-493 group weighed significantly less than either the switch or vehicle groups (p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814402
03AnimalAnimal study (in vivo)Efficacy outcome
In Arc-Pomc knockout mice, RM-493 increased energy expenditure versus the switch group (p<0.05).
In plain wordsIn mice lacking hypothalamic Pomc, RM-493 increased energy expenditure versus the switch group.
Peptide
Setmelanotide
Outcome
IncreaseEnergy expenditure
Study
mousen: not reported in source
Arc-Pomc knockout mice
Comparator
Switch group
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
Arc-Pomc knockout mice on RM-493 also had higher energy expenditure when compared to the switch and vehicle groups (p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814403
04AnimalAnimal study (in vivo)Efficacy outcome
In Arc-Pomc knockout mice, RM-493 increased energy expenditure versus vehicle (p<0.05).
In plain wordsIn mice lacking hypothalamic Pomc, RM-493 increased energy expenditure versus vehicle.
Peptide
Setmelanotide
Outcome
IncreaseEnergy expenditure
Study
mousen: not reported in source
Arc-Pomc knockout mice
Comparator
Vehicle group
Outcome group
Energy expenditure and thermogenesis · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
Arc-Pomc knockout mice on RM-493 also had higher energy expenditure when compared to the switch and vehicle groups (p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814404
05AnimalAnimal study (in vivo)Efficacy outcome
In Arc-Pomc knockout mice, RM-493 improved the glucose-insulin index (p<0.05); the abstract does not specify numeric direction or comparator.
In plain wordsIn mice lacking hypothalamic Pomc, RM-493 improved the glucose-insulin index; the abstract does not specify the comparator.
Peptide
Setmelanotide
Outcome
Direction not reportedGlucose-insulin index
Study
mousen: not reported in source
Arc-Pomc knockout mice
Outcome group
Glycemic control · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
In addition, RM-493 improved the glucose-insulin index for Arc-Pomc knockout mice (p<0.05).
2 context sentences(design, population, supporting numbers)
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814405
06AnimalAnimal study (in vivo)Efficacy outcome
In high-fat-fed wildtype mice, chronic RM-493 did not change the measured outcomes versus the switch group in preliminary results.
In plain wordsIn high-fat-fed wildtype mice, chronic RM-493 did not change the measured outcomes versus the switch group in preliminary results.
Peptide
Setmelanotide
Outcome
No significant changeMetabolic and body measurements in wildtype mice
Study
mousen: not reported in source
Wildtype mice fed a 45% high-fat diet
Comparator
Switch group
Outcome group
Cardiometabolic risk factors · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
According to our preliminary results, wildtype mice on high-fat diet, treated chronically with RM-493, did not differ in any of these measurements from their switch and vehicle groups.
3 context sentences(design, population, supporting numbers)
Summary · context
We serially measured body weight, food intake, body composition, glucose tolerance, insulin tolerance, and several measures of metabolism using the Comprehensive Lab Animal Monitoring System, including oxygen consumption, energy expenditure, ambulatory activity and lipid and glucose oxidation.
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814406
07AnimalAnimal study (in vivo)Efficacy outcome
In high-fat-fed wildtype mice, chronic RM-493 did not change the measured outcomes versus vehicle in preliminary results.
In plain wordsIn high-fat-fed wildtype mice, chronic RM-493 did not change the measured outcomes versus vehicle in preliminary results.
Peptide
Setmelanotide
Outcome
No significant changeMetabolic and body measurements in wildtype mice
Study
mousen: not reported in source
Wildtype mice fed a 45% high-fat diet
Comparator
Vehicle group
Outcome group
Cardiometabolic risk factors · Metabolic and weight
Studied dose
Dose not stated · subcutaneous osmotic minipumps · 4–24 weeks of ageAs given in this study (mouse).
Source sentences
Summary
According to our preliminary results, wildtype mice on high-fat diet, treated chronically with RM-493, did not differ in any of these measurements from their switch and vehicle groups.
3 context sentences(design, population, supporting numbers)
Summary · context
We serially measured body weight, food intake, body composition, glucose tolerance, insulin tolerance, and several measures of metabolism using the Comprehensive Lab Animal Monitoring System, including oxygen consumption, energy expenditure, ambulatory activity and lipid and glucose oxidation.
Summary · context
In this preclinical study, we investigated the effects of chronic RM-493 treatment using subcutaneously implanted osmotic minipumps in two groups of male mice: Arc-Pomc knockout mice, fed regular chow throughout the study period, and their wildtype counterparts, fed a 45% high-fat diet.
Summary · context
Each of these groups of mice was randomized into three treatment cohorts at weaning: one that was given RM-493 throughout the entire study period (4–24 weeks of age, “RM-493” group),
Report a problemFND-9096814407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

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Version 2Current
28 Oct 2026, 02:03 UTC
Study results updated
Version 1
27 Oct 2026, 16:36 UTC
First added · source update from Europe PMC

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Abstract

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