Modified form · 3 amino acids · 676 Da

Palmitoyl tripeptide-38 studies and research data

PepBank has 3 palmitoyl tripeptide-38 studies with results. None of them gave palmitoyl tripeptide-38. Data as of 2026-10-30.

Searches 0 results and 4 papers. Newer studies from Europe PMC

Results in people

0% of 0 results

Results in animals

0% of 0 results

Results in lab cells

0% of 0 results

From computer models

0% of 0 results

The molecule

Palmitoyl tripeptide-38 identity

Identifiers, parent molecule, targets and development stage, from curated data.

Palmitoyl tripeptide-38 contains lysine, methionine sulfone and lysine, with an N-terminal palmitoyl group. Matrixyl synthe'6 is a commercial solution containing it. Matrixyl and Matrixyl 3000 are different ingredients.

Kind: Modified form · 3 residues
Identifiers: PubChem CID71587932 (opens in a new tab)UNIIT7A529FB8O (opens in a new tab)CAS1101448-24-1
Development: UnknownSederma / Croda (Matrixyl synthe'6 cosmetic ingredient)Croda markets Matrixyl synthe'6 as a cosmetic ingredient containing this peptide. No formal drug-development phase was established. One registry hit tested a multi-product regimen containing the peptide. It did not isolate the peptide effect. Source (opens in a new tab)

Targets

No molecular target is recorded for this peptide.

Sequence and structure

Residues, differences from the parent, calculated properties and 3D structure. Source values and calculated values are shown separately.

Sequence

3 amino acids · 2 modifications

Properties

From identity sources

Formula: C₃₃H₆₅N₅O₇S
Molecular weight: 675.97 g/mol
Monoisotopic mass: 675.4605 Da

PubChem CID 71587932(opens in a new tab)retrieved 2026-10-27
FDA GSRS T7A529FB8O(opens in a new tab)retrieved 2026-10-27

Calculated from the sequence

pKa set

Some values cannot be calculated. A modification changes this value and is not modeled here (for example a lipid, metal or linker).

Average mass: Not calculated
Monoisotopic mass: Not calculated
Isoelectric point (pI): Not calculated
Net charge at pH 7.4: Not calculated
GRAVY (hydropathy): −1.967; Mean Kyte-Doolittle hydropathy · Kyte and Doolittle 1982; Negative: hydrophilic on average.
Extinction coefficient, 280 nm (Cys reduced): 0 M⁻¹ cm⁻¹; 5500 x Trp + 1490 x Tyr · Pace et al. 1995 (ExPASy ProtParam); No Trp or Tyr: absorbance at 280 nm cannot measure this peptide.
Instability index: 115.33; Dipeptide instability weights (DIWV) · Guruprasad et al. 1990; Above 40: classed as possibly unstable (ExPASy).
Aliphatic index: 0.0; Mole % A + 2.9 V + 3.9 (I + L) · Ikai 1980
Boman index: 2.92 kcal/mol; Mean solubility value (negated) · Boman 2003; Above 2.48: high protein-binding potential (Boman).
Hydrophobic moment (μH): Not calculated; The sequence is too short for this method.

Not included: lipid chain, other modification. Mass, charge and pI are not calculated; use the identity-source values.
The N-terminal group is not modeled.
Defined and validated for proteins; use with care for short peptides.
Assumes an ideal alpha helix. Many short peptides are not helical.

@pepdb/chem 0.2.0 · EMBOSS pKa set · ExPASy residue masses

Net charge by pH

No charge curve

A modification changes this value and is not modeled here (for example a lipid, metal or linker).

Composition

Hydrophobic33% (1)M
Positive67% (2)K

3 residues. Each residue counts in one class; F and W count as aromatic.

A Ala0 · 0%

I Ile0 · 0%

L Leu0 · 0%

M Met1 · 33%

V Val0 · 0%

F Phe0 · 0%

W Trp0 · 0%

Y Tyr0 · 0%

H His0 · 0%

K Lys2 · 67%

R Arg0 · 0%

D Asp0 · 0%

E Glu0 · 0%

N Asn0 · 0%

Q Gln0 · 0%

S Ser0 · 0%

T Thr0 · 0%

C Cys0 · 0%

G Gly0 · 0%

P Pro0 · 0%

3D structure

No 3D structure

No experimental structure (PDB) and no UniProt entry for an AlphaFold model are listed for this peptide. Synthetic peptides often have neither. The sequence view above is the reference.

2D structure

Draws the structure in your browser with RDKit (about 2.3 MB, loaded once).

SMILES fromPubChem CID 71587932(opens in a new tab)

CCCCCCCCCCCCCCCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCS(=O)(=O)C)C(=O)N[C@@H](CCCCN)C(=O)O

Results by area

Palmitoyl tripeptide-38 results by year and outcome

Counts are exact and come from studies that gave the peptide.

Studies by year

3 of 4 studies have results (75%), published 2015 to 2020. Top row: every study. Bottom row: studies with results about Palmitoyl tripeptide-38, by class. The rows use different scales.

Studies
Human
Animal
Lab
Computer model
Natural levels, tool or combination only

Studies4 in all, 2015 to 2021

Studies with results3 in all, 2015 to 2020

Retracted studies are left out. A study with results in two classes counts in both.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

What the studies measured

People first in each area, then animals, then lab cells. Counts are exact and come from studies that gave the peptide.

No study of Palmitoyl tripeptide-38 has results in PepBank yet.

Trials and papers

Palmitoyl tripeptide-38 trials

Registered trials that test the peptide, with phase, status and dates. A dot marks trials with posted results.

StatusPhase

0 trials match. Highest phase first. Data from ClinicalTrials.gov.

No trial matches these filters.

1 more mentions it but does not test it. They are not trials of Palmitoyl tripeptide-38: they only measure it (a blood level or an eligibility term) or name it in their text.

Papers

Studies on this peptide. Some have results. The others have none yet.

Sort

Design

4 studies match. Retracted studies are left out.

Showing 4 of 4 studiesquery qry_fd335cc0a4c00e58619e2723

Studies with results

3 studies

Not a test of Palmitoyl tripeptide-38 alone · 2016

11 results

Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.

Sanz et al. 2016Journal of cosmetic dermatologycited by 15

PMID 26424007DOI 10.1111/jocd.12173PUB-26424007

Full text at the publisher11 results where Palmitoyl tripeptide-38 was a tool, carrier or part of a combination

Publisher page See results (11)

Not a test of Palmitoyl tripeptide-38 alone · 2015

6 results

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin.

Jr et al. 2015Journal of drugs in dermatology : JDDcited by 10

PMID 26151786PUB-26151786

Full text at the publisher6 results where Palmitoyl tripeptide-38 was a tool, carrier or part of a combination

Publisher page See results (6)

Not a test of Palmitoyl tripeptide-38 alone · 2020

7 results

A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception.

Lintner et al. 2020Journal of cosmetic dermatologycited by 8

PMID 33103342PMC7756752DOI 10.1111/jocd.13770PUB-33103342

Free to read · publisher termsCC BY-NC-ND7 results where Palmitoyl tripeptide-38 was a tool, carrier or part of a combination

Read at source See results (7)

More studies

1 study

PubMed tag: Preprint · 2021

A Face Serum Containing Bakuchiol, Palmitoyl Tripeptide-38, Hydrolyzed Hyaluronic Acid and a Polyherbal and Vitamin Blend Improves Skin Quality in Human Volunteers and Protects Skin Structure In vitro

West et al. 2021Preprints.org

DOI 10.20944/preprints202106.0580.v1PUB-99766430

CC BY

Download PDF

Newer studies

PepBank reads each paper before it shows the results. This search looks in Europe PMC for newer papers that PepBank has not read yet.

Palmitoyl tripeptide-38 studies: 3 papers with results

Page 1 of 1

Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.
Sanz MT · Journal of cosmetic dermatology · 2016
Not a test of Palmitoyl tripeptide-38 alone · 11 results
A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception.
Lintner K · Journal of cosmetic dermatology · 2020
Not a test of Palmitoyl tripeptide-38 alone · 7 results
An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin.
Herndon JH Jr · Journal of drugs in dermatology : JDD · 2015
Not a test of Palmitoyl tripeptide-38 alone · 6 results

Status and safety

Regulatory and safety

Approval and sport status, and the safety outcomes reported in study results. Laws and labels change, so check the regulator for the current status.

Regulatory status by jurisdiction, with date and source
Jurisdiction	Body	Status	As of	Source
US	FDA	No FDA-approved medicine was established in this review. A UNII identifies a substance and does not establish approval. DailyMed lists DERMA LIP PLUMPER BALM, containing this peptide, as unapproved drug other. FDA does not pre-approve cosmetic ingredients, except certain color additives.	27 Oct 2026	dailymed.nlm.nih.gov (opens in a new tab)
EU	EMA	No product-specific EMA medicinal authorisation was established by the exact-name search. Results concerned other substances. CosIng listing does not establish medicinal authorisation. This search does not exclude national authorisations.	27 Oct 2026	ema.europa.eu (opens in a new tab)
Sport	WADA	Status unknown The 2026 list does not name palmitoyl tripeptide-38 or Matrixyl.	2026 List	wada-ama.org (opens in a new tab)
European Union	Note	INCI: PALMITOYL TRIPEPTIDE-38. CosIng reference 85966. Secondary ingredient dictionaries report this entry. The official page did not return the ingredient detail during this check. An inventory entry is not a medicinal approval.	27 Oct 2026	specialchem.com (opens in a new tab)
Canada	Note	Health Canada NHPID lists an approved chemical name for non-medicinal skin-conditioning use by the topical route. This ingredient record does not establish an approved medicine.	27 Oct 2026	webprod.hc-sc.gc.ca (opens in a new tab)

Safety outcomes

Reported effects from study results.

No study results yet

No safety results yet. That does not mean the peptide is safe.

Doses studied

The doses that these studies used. They are not recommendations.

No dose was reported in the study results.

PepBank is a research reference. Talk to a doctor before you use any peptide.

Data

Data and API

Data version, change history and code for this peptide.

Data version 30856030 Oct 2026

Peptide

Peptide id: PEP-000156
Peptide version: 2
Peptide hash: 46e315a15701bedd…
Data version: 308560

Latest changes

27 Oct 2026UpdatedData version 287304
27 Oct 2026CreatedData version 256749

For developers

curl -s https://pepbank.io/v1/briefs/palmitoyl-tripeptide-38

Evidence summary for Palmitoyl tripeptide-38: counts by class, key results with sources, notices, data version.

Peptide as JSON Evidence summary as JSON

Palmitoyl tripeptide-38 studies and research data

Palmitoyl tripeptide-38 identity

Targets

Sequence and structure

Sequence

Properties

Net charge by pH

Composition

3D structure

2D structure

Palmitoyl tripeptide-38 results by year and outcome

What the studies measured

Palmitoyl tripeptide-38 trials

Papers

Studies with results

Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin.

A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception.

More studies

A Face Serum Containing Bakuchiol, Palmitoyl Tripeptide-38, Hydrolyzed Hyaluronic Acid and a Polyherbal and Vitamin Blend Improves Skin Quality in Human Volunteers and Protects Skin Structure In vitro

Newer studies

Palmitoyl tripeptide-38 studies: 3 papers with results

Regulatory and safety

Doses studied

Data and API

Peptide

Latest changes

For developers

Related peptides

Palmitoyl tripeptide-38 results by year and outcome

Palmitoyl tripeptide-38 trials

Papers

Studies with results

Biorevitalizing effect of a novel facial serum containing apple stem cell extract, pro-collagen lipopeptide, creatine, and urea on skin aging signs.

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin.

A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception.

More studies

A Face Serum Containing Bakuchiol, Palmitoyl Tripeptide-38, Hydrolyzed Hyaluronic Acid and a Polyherbal and Vitamin Blend Improves Skin Quality in Human Volunteers and Protects Skin Structure In vitro

Palmitoyl tripeptide-38 studies: 3 papers with results

Regulatory and safety

Doses studied

Data and API

Peptide

Latest changes

For developers