A serum containing vitamins C & E and a matrix-repair tripeptide reduces facial signs of aging as evidenced by Primos® analysis and frequently repeated auto-perception.

Lintner K, Gerstein F, Solish N

Journal of cosmetic dermatology26 Oct 2020Cited by 8 (Europe PMC)

PMID33103342PMCIDPMC7756752DOI10.1111/jocd.13770PepBankPUB-33103342

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Palmitoyl tripeptide-38.

01HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with photoaging, the multi-active serum significantly reduced skin roughness by 8%-9%.
In plain wordsIn women with photoaging, the multi-active serum reduced skin roughness from baseline.
Peptide
Palmitoyl tripeptide-38
Outcome
DecreaseSkin roughness
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Skin roughness parameters decrease
8 to 9%
women with photoaging, multi-active serum
Source sentences
Summary
Skin-roughness parameters decreased significantly by 8%-9% (P < .05) and subjects experienced a significant increase in skin isotropy (P < .05).
1 context sentence(design, population, supporting numbers)
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334201
02HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with photoaging, the multi-active serum significantly increased skin isotropy.
In plain wordsIn women with photoaging, the multi-active serum improved skin surface uniformity from baseline.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseSkin isotropy
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Skin-roughness parameters decreased significantly by 8%-9% (P < .05) and subjects experienced a significant increase in skin isotropy (P < .05).
1 context sentence(design, population, supporting numbers)
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334202
03HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with photoaging, the multi-active serum reduced redness by 9%.
In plain wordsIn women with photoaging, the multi-active serum reduced redness from baseline.
Peptide
Palmitoyl tripeptide-38
Outcome
DecreaseRedness
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Redness decrease
9%
women with photoaging, multi-active serum
Source sentences
Summary
Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles.
1 context sentence(design, population, supporting numbers)
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334203
04HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
In women with photoaging, the multi-active serum increased skin homogeneity by 8%.
In plain wordsIn women with photoaging, the multi-active serum improved skin uniformity from baseline.
Peptide
Palmitoyl tripeptide-38
Outcome
IncreaseSkin homogeneity
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Measurements
Homogeneity increase
8%
women with photoaging, multi-active serum
Source sentences
Summary
Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles.
1 context sentence(design, population, supporting numbers)
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334204
05HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
Women with photoaging perceived significant radiance improvements with the multi-active serum.
In plain wordsWomen with photoaging reported better skin radiance than at baseline with the multi-active serum.
Peptide
Palmitoyl tripeptide-38
Outcome
Direction not reportedPerceived radiance
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles.
2 context sentences(design, population, supporting numbers)
Summary · context
Subjects completed self-assessment questionnaires every third day of the trial period for radiance, homogeneity, and wrinkle appearance.
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334205
06HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
Women with photoaging perceived significant complexion improvements with the multi-active serum.
In plain wordsWomen with photoaging reported better complexion than at baseline with the multi-active serum.
Peptide
Palmitoyl tripeptide-38
Outcome
Direction not reportedPerceived complexion
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles.
2 context sentences(design, population, supporting numbers)
Summary · context
Subjects completed self-assessment questionnaires every third day of the trial period for radiance, homogeneity, and wrinkle appearance.
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334206
07HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome
Women with photoaging perceived significant wrinkle improvements with the multi-active serum.
In plain wordsWomen with photoaging reported improved wrinkle appearance compared with baseline with the multi-active serum.
Peptide
Palmitoyl tripeptide-38
Outcome
Direction not reportedPerceived wrinkles
Study
n: not reported in source
Outcome group
Skin and hair · Skin and wound
Source sentences
Summary
Photographic analysis revealed significant improvements in skin tone, with a 9% decrease in redness and 8% increase in homogeneity (P < .0001 for both), in excellent agreement with subjects' perception of significant improvements of radiance, complexion, and wrinkles.
2 context sentences(design, population, supporting numbers)
Summary · context
Subjects completed self-assessment questionnaires every third day of the trial period for radiance, homogeneity, and wrinkle appearance.
Summary · context
In an open-label study women of ≥40 years with visible signs of photoaging applied a serum comprising l-ascorbic acid USP (15% w/v), tocopheryl acetate USP, and 5 ppm palmitoyl tripeptide-38 to the face once daily for 56 days.
In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.
Report a problemFND-3310334207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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