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Study · Not a test of the peptide alone · 2015

6 results

An Open Label Clinical Trial of a Multi-Ingredient Anti-Aging Moisturizer Designed to Improve the Appearance of Facial Skin.

Herndon JH Jr, Jiang L, Kononov T, Fox T

Journal of drugs in dermatology : JDD1 Jul 2015Cited by 10 (Europe PMC)

PMID26151786 (opens in a new tab)PepBankPUB-26151786
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone6

In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Palmitoyl tripeptide-38.

  1. 01HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome

    In women, the multi-ingredient moisturizer significantly improved all clinical grading parameters versus baseline after 8 weeks.

    In plain wordsIn women, the multi-ingredient moisturizer improved all assessed clinical skin scores compared with baseline.

    Peptide
    Palmitoyl tripeptide-38
    Outcome
    Direction not reportedClinical grading parameters at 8 weeks
    Study

    n = 37

    Comparator
    baseline
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    After 8 weeks of twice daily use, clinical evaluation results show that the multi-ingredient anti-aging moisturizer produced a statistically significant improvement in the scores of all clinical grading parameters assessed compared to baseline.
    3 context sentences
    Summary · context
    Parameters studied included fine lines and wrinkles, clarity/brightness, visual roughness, tactile roughness, evenness of skin tone (redness), evenness of skin tone (hyperpigmentation) and overall appearance.
    Summary · context
    Thirty-seven female subjects, ages 35-60 years completed the study.
    Summary · context
    Effective ingredients incorporated into the facial anti-aging moisturizer include: Astragalus membranaceus root extract, a peptide blend including palmitoyl tripeptide-38, standardized rosemary leaf extract (ursolic acid), tetrahexyldecyl ascorbate (THD ascorbate) and ubiquinone (coenzyme Q10).

    In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.

  2. 02HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome

    In women, the multi-ingredient moisturizer showed greater significant clinical improvements at 12 weeks.

    In plain wordsIn women, the multi-ingredient moisturizer showed greater clinical improvements at 12 weeks.

    Peptide
    Palmitoyl tripeptide-38
    Outcome
    Direction not reportedClinical grading parameters at 12 weeks
    Study

    n = 37

    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    A greater statistically significant improvement was seen at 12 weeks.
    3 context sentences
    Summary · context
    After 8 weeks of twice daily use, clinical evaluation results show that the multi-ingredient anti-aging moisturizer produced a statistically significant improvement in the scores of all clinical grading parameters assessed compared to baseline.
    Summary · context
    Thirty-seven female subjects, ages 35-60 years completed the study.
    Summary · context
    Effective ingredients incorporated into the facial anti-aging moisturizer include: Astragalus membranaceus root extract, a peptide blend including palmitoyl tripeptide-38, standardized rosemary leaf extract (ursolic acid), tetrahexyldecyl ascorbate (THD ascorbate) and ubiquinone (coenzyme Q10).

    In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.

  3. 03HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome

    In women, favorable product efficacy questionnaire results significantly exceeded unfavorable results at week 12.

    In plain wordsIn women, favorable moisturizer efficacy ratings exceeded unfavorable ratings.

    Peptide
    Palmitoyl tripeptide-38
    Outcome
    Direction not reportedProduct efficacy self-assessment
    Study

    n = 37

    Comparator
    unfavorable results
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    At week 12, there was a statistically significant percentage of favorable results versus unfavorable results in all product efficacy and product aesthetic self-assessment questionnaire results.
    2 context sentences
    Summary · context
    Thirty-seven female subjects, ages 35-60 years completed the study.
    Summary · context
    Effective ingredients incorporated into the facial anti-aging moisturizer include: Astragalus membranaceus root extract, a peptide blend including palmitoyl tripeptide-38, standardized rosemary leaf extract (ursolic acid), tetrahexyldecyl ascorbate (THD ascorbate) and ubiquinone (coenzyme Q10).

    In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.

  4. 04HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialEfficacy outcome

    In women, favorable product aesthetic questionnaire results significantly exceeded unfavorable results at week 12.

    In plain wordsIn women, favorable moisturizer aesthetic ratings exceeded unfavorable ratings.

    Peptide
    Palmitoyl tripeptide-38
    Outcome
    Direction not reportedProduct aesthetic self-assessment
    Study

    n = 37

    Comparator
    unfavorable results
    Outcome group
    Skin and hair · Skin and wound

    Source sentences

    Summary
    At week 12, there was a statistically significant percentage of favorable results versus unfavorable results in all product efficacy and product aesthetic self-assessment questionnaire results.
    2 context sentences
    Summary · context
    Thirty-seven female subjects, ages 35-60 years completed the study.
    Summary · context
    Effective ingredients incorporated into the facial anti-aging moisturizer include: Astragalus membranaceus root extract, a peptide blend including palmitoyl tripeptide-38, standardized rosemary leaf extract (ursolic acid), tetrahexyldecyl ascorbate (THD ascorbate) and ubiquinone (coenzyme Q10).

    In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.

  5. 05HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialSafety outcome

    In women, the multi-ingredient moisturizer was judged mild and well tolerated.

    In plain wordsWomen tolerated the multi-ingredient moisturizer well.

    Peptide
    Palmitoyl tripeptide-38
    Outcome
    Not applicableOverall tolerability
    Study

    n = 37

    Outcome group
    Adverse events · Skin and wound

    Source sentences

    Summary
    Additionally, the multi-ingredient anti-aging moisturizer is judged to be mild and well tolerated.
    2 context sentences
    Summary · context
    Thirty-seven female subjects, ages 35-60 years completed the study.
    Summary · context
    Effective ingredients incorporated into the facial anti-aging moisturizer include: Astragalus membranaceus root extract, a peptide blend including palmitoyl tripeptide-38, standardized rosemary leaf extract (ursolic acid), tetrahexyldecyl ascorbate (THD ascorbate) and ubiquinone (coenzyme Q10).

    In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.

  6. 06HumanNot a test of Palmitoyl tripeptide-38 aloneNon-randomized trialSafety outcome

    In women, tolerability scores did not significantly increase versus baseline with the multi-ingredient moisturizer.

    In plain wordsIn women, moisturizer tolerability scores did not significantly increase compared with baseline.

    Peptide
    Palmitoyl tripeptide-38
    Outcome
    No significant changeTolerability scores
    Study

    n = 37

    Comparator
    baseline
    Outcome group
    Adverse events · Skin and wound

    Source sentences

    Summary
    Several tolerability parameters were assessed at all time points with no statistically significant increase in any of the scores compared to baseline.
    2 context sentences
    Summary · context
    Thirty-seven female subjects, ages 35-60 years completed the study.
    Summary · context
    Effective ingredients incorporated into the facial anti-aging moisturizer include: Astragalus membranaceus root extract, a peptide blend including palmitoyl tripeptide-38, standardized rosemary leaf extract (ursolic acid), tetrahexyldecyl ascorbate (THD ascorbate) and ubiquinone (coenzyme Q10).

    In this study, Palmitoyl tripeptide-38 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Palmitoyl tripeptide-38.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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